New Antimicrobial Bioactivity against Multidrug-Resistant Gram-Positive Bacteria of Kinase Inhibitor IMD0354

Molecular mechanisms of vancomycin resistance

(2020) Peter J. Stogios et al.   PROTEIN SCIENCE

Anti-MRSA agent discovery using Caenorhabditis elegans-based high-throughput screening

(2020) Soo Min Kim et al.   JOURNAL OF MICROBIOLOGY

The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus

(2020) Wooseong Kim et al.   mBio

Evolution of Multi-Resistance to Vancomycin, Daptomycin, and Linezolid in Methicillin-Resistant Staphylococcus aureus Causing Persistent Bacteremia

(2020) Chih-Jung Chen et al.   Frontiers in Microbiology

A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus

(2019) Wooseong Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-cancer activity of the novel 2-hydroxydiarylamide derivatives IMD-0354 and KRT1853 through suppression of cancer cell invasion, proliferation, and survival mediated by TMPRSS4

(2019) Solbi Kim et al.   Scientific Reports

Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-Negative Bacteria

(2019) William T. Barker et al.   ACS Infectious Diseases

Both live and dead Enterococci activate Caenorhabditis elegans host defense via immune and stress pathways

(2018) Grace J. Yuen et al.   Virulence

Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology

(2018) Sahreena Lakhundi et al.   CLINICAL MICROBIOLOGY REVIEWS

A new class of synthetic retinoid antibiotics effective against bacterial persisters

(2018) Wooseong Kim et al.   NATURE

Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters

(2018) Wooseong Kim et al.   ACS Infectious Diseases

Staphylococcus aureus biofilm: a complex developmental organism

(2017) Derek E. Moormeier et al.   MOLECULAR MICROBIOLOGY

DNA-crosslinker cisplatin eradicates bacterial persister cells

(2016) Nityananda Chowdhury et al.   BIOTECHNOLOGY AND BIOENGINEERING

NH125 kills methicillin-resistantStaphylococcus aureuspersisters by lipid bilayer disruption

(2016) Wooseong Kim et al.   Future Medicinal Chemistry

Combatting bacterial infections by killing persister cells with mitomycin C

(2015) Brian W. Kwan et al.   ENVIRONMENTAL MICROBIOLOGY

Antimicrobial susceptibility pattern of vancomycin resistant enterococci to newer antimicrobial agents

(2015) Varsha Gupta et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control

(2015) S. L. Percival et al.   JOURNAL OF MEDICAL MICROBIOLOGY

IKK  Regulates VEGF Expression and Is a Potential Therapeutic Target for Ovarian Cancer as an Antiangiogenic Treatment

(2015) Y. Kinose et al.   MOLECULAR CANCER THERAPEUTICS

Clinical Implications of Vancomycin Heteroresistant and Intermediately SusceptibleStaphylococcus aureus

(2015) Diane M. Gomes et al.   PHARMACOTHERAPY

Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy

(2015) Wooseong Kim et al.   PLoS One

Anti-Staphylococcal Biofilm Effects of Human Cathelicidin Peptides

(2015) Biswajit Mishra et al.   ACS Medicinal Chemistry Letters

A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus

(2015) Rajmohan Rajamuthiah et al.   PLoS One

Low-dose cisplatin administration to septic mice improves bacterial clearance and programs peritoneal macrophage polarization to M1 phenotype

(2014) Yanyan Li et al.   Pathogens and Disease

Anti-biofilm agents: recent breakthrough against multi-drug resistantStaphylococcus aureus

(2014) Pooi Y. Chung et al.   Pathogens and Disease

Clinical relevance of the ESKAPE pathogens

(2013) Jack N Pendleton et al.   Expert Review of Anti-Infective Therapy

Applying insights from biofilm biology to drug development — can a new approach be developed?

(2013) Thomas Bjarnsholt et al.   NATURE REVIEWS DRUG DISCOVERY

IMD-0354 Targets Breast Cancer Stem Cells: A Novel Approach for an Adjuvant to Chemotherapy to Prevent Multidrug Resistance in a Murine Model

(2013) Azucena Gomez-Cabrero et al.   PLoS One

Structural and Functional Characterization of VanG d-Ala:d-Ser Ligase Associated with Vancomycin Resistance inEnterococcus faecalis

(2012) Djalal Meziane-Cherif et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtiter Dish Biofilm Formation Assay

(2011) George A. O'Toole   Jove-Journal of Visualized Experiments

Community-Associated Methicillin-Resistant Staphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic

(2010) M. Z. David et al.   CLINICAL MICROBIOLOGY REVIEWS

Resistance or decreased susceptibility to glycopeptides, daptomycin, and linezolid in methicillin-resistant Staphylococcus aureus

(2010) Esteban Nannini et al.   CURRENT OPINION IN PHARMACOLOGY

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

A mutation of cdc-25.1 causes defects in germ cells but not in somatic tissues in C. elegans

(2009) Jiyoung Kim et al.   MOLECULES AND CELLS

Antiallergic and Anti-Inflammatory Effects of a Novel IκB Kinase β Inhibitor, IMD-0354, in a Mouse Model of Allergic Inflammation

(2008) Akemi Sugita et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES