Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Yingping Wu, Shufa Zheng, Tian Liu, Xueke Liu, Huina Tang, Yutong He, Wei Xu, Lele Li, Wenxu Yu, Ke Xing, Xiaoping Xia
Summary: Whole-genome sequencing analysis of three COVID-19-confirmed patients revealed that the haplotype diversity of SARS-CoV-2 may lead to viral adaptation for persistent shedding in multiple recurrences, impacting the clinical management of COVID-19 patients with long-term hospitalization or cases of recurrence.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Rima Hajjo, Dima A. Sabbah, Sanaa K. Bardaweel, Alexander Tropsha
Summary: Research shows that myocarditis and pericarditis are most commonly associated with COVID-19 vaccines, followed by non-COVID-19 vaccines; the frequency of cardiac adverse events is influenced by various factors; interferon-gamma plays a central role in the biological processes leading to cardiac adverse events.
Article
Immunology
Elizabeth T. Jacobs, Collin J. Catalfamo, Paulina M. Colombo, Sana M. Khan, Erika Austhof, Felina Cordova-Marks, Kacey C. Ernst, Leslie V. Farland, Kristen Pogreba-Brown
Summary: Post-acute sequelae of COVID-19 (PASC) are conditions that occur or remain at least 28 days after SARS-CoV-2 infection. Pre-existing conditions such as asthma, chronic constipation, reflux, rheumatoid arthritis, seasonal allergies, and depression/anxiety are associated with an increased risk for PASC. Respiratory, gastrointestinal, and autoimmune conditions also show significant associations with PASC.
JOURNAL OF AUTOIMMUNITY
(2023)
Review
Microbiology
Jakob J. Malin, Isabelle Suarez, Vanessa Priesner, Gerd Fatkenheuer, Jan Rybniker
Summary: Remdesivir is the first approved treatment for COVID-19, showing therapeutic and prophylactic effects in animal models of various viruses. However, it failed in a clinical trial on ebolavirus disease but showed beneficial effects for patients with COVID-19 in a placebo-controlled trial.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Article
Virology
Seongman Bae, Ji Yeun Kim, So Yun Lim, Heedo Park, Hye Hee Cha, Ji-Soo Kwon, Mi Hyun Suh, Hyun Jung Lee, Joon Seo Lim, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Ho Young Lee, Sohyun Lee, Man-Seong Park, Sung-Han Kim
Summary: The study found that asymptomatic COVID-19 patients have a similar viral load to symptomatic patients during the early stages of the disease, but their infectivity rapidly decreases with the loss of symptoms.
Review
Clinical Neurology
Michael S. Xydakis, Mark W. Albers, Eric H. Holbrook, Dina M. Lyon, Robert Y. Shih, Johannes A. Frasnelli, Axel Pagenstecher, Alexandra Kupke, Lynn W. Enquist, Stanley Perlman
Summary: COVID-19 is often associated with olfactory dysfunction, providing a research opportunity to study the natural course of this neurological finding. However, limited by sample sizes and lack of advanced neuroimaging data, there is still a substantial gap in knowledge regarding the mechanisms of olfactory impairment. Persistent olfactory deficits post-SARS-CoV-2 infection could potentially be a marker for increased long-term risk of neurological disease.
Review
Medicine, General & Internal
Kingsley Badu, Kolapo Oyebola, Julien Z. B. Zahouli, Adeniyi Francis Fagbamigbe, Dziedzom K. de Souza, Natisha Dukhi, Ebenezer F. Amankwaa, Mai F. Tolba, Augustina A. Sylverken, Lydia Mosi, Priscilla Kolibea Mante, Damaris Matoke-Muhia, Nowsheen Goonoo
Summary: The evolving nature of SARS-CoV-2 requires periodic revisions of COVID-19 patient treatment and discharge guidelines. The WHO plays a crucial role in handling country-level pandemic preparedness and patient management protocols. Patients can be released from isolation centers on the 10th day following clinical symptom manifestation, with at least 72 additional hours following the resolution of symptoms.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yun Lin, Bingyi Yang, Sarah Cobey, Eric H. Y. Lau, Dillon C. Adam, Jessica Y. Wong, Helen S. Bond, Justin K. Cheung, Faith Ho, Huizhi Gao, Sheikh Taslim Ali, Nancy H. L. Leung, Tim K. Tsang, Peng Wu, Gabriel M. Leung, Benjamin J. Cowling
Summary: Analysis of viral load data on confirmed cases can improve real-time estimation of the reproductive number, enabling more timely tracking of epidemic dynamics.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Yebei Li, Meiying Rao, Gaosi Xu
Summary: The emergence of acute kidney disease (AKD) following COVID-19 vaccination has raised concerns. This review summarizes hypotheses and pathogenesis of AKD caused by COVID-19 vaccines, aiming to assist clinical assessment and management of this condition.
Article
Microbiology
Chi-Ju Hsu, Wen-Chin Lin, Yu-Ching Chou, Chuen-Mi Yang, Hsueh-Ling Wu, Yun-Hsiang Cheng, Ping-Cheng Liu, Jia-Yu Chang, Hsing-Yu Chen, Jun-Ren Sun
Summary: This study investigates the long-term lung pathology and blood chemistry changes in Syrian hamsters infected with SARS-CoV-2. It found that the virus has an acute onset and recovery course, causing lung damage and long-term changes in blood biochemistry. These findings are important for understanding the long-term health consequences of COVID-19.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Adam M. Spivak, Bradley J. Barney, Tom Greene, Richard Holubkov, Cody S. Olsen, Jordan Bridges, Raj Srivastava, Brandon Webb, Frances Sebahar, Ainsley Huffman, Christina F. Pacchia, J. Michael Dean, Rachel Hess
Summary: Early in the COVID-19 pandemic, hydroxychloroquine was considered as a potential early treatment to prevent clinical worsening. However, this study found that hydroxychloroquine did not significantly alter the natural history of early COVID-19 disease.
MICROBIOLOGY SPECTRUM
(2023)
Review
Medical Laboratory Technology
Marco Ciotti, Massimo Ciccozzi, Massimo Pieri, Sergio Bernardini
Summary: The article discusses the development of COVID-19 vaccines, the impact of viral variants on transmission and virus antibodies, and methods for measuring vaccine antibody responses. It also emphasizes the importance of using the WHO International Standard to accurately calibrate immunoassays.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Article
Medicine, General & Internal
Asuka Ito, Takayuki Okada, Naoki Minato, Fumiyuki Hattori
Summary: This article reported a case of a recovered COVID-19 patient who tested negative for PCR before surgery but tested positive during the operation. Pathological analysis showed the presence of virus-like particles, and cell-based assay revealed a higher concentration of type-I interferons in the patient's serum, indicating ongoing internal viral shedding and immune response after recovery.
FRONTIERS IN MEDICINE
(2022)
Editorial Material
Multidisciplinary Sciences
Sergei L. Kosakovsky Pond, Darren Martin
Summary: Molnupiravir, an antiviral drug for COVID-19, can cause multiple mutations in the SARS-CoV-2 genome, potentially accelerating the evolution and transmission of viral variants.
Review
Engineering, Biomedical
Marialuisa Gandolfi, Stefano Mazzoleni, Giovanni Morone, Marco Iosa, Filippo Galletti, Nicola Smania
Summary: Robotic-assisted upper limb rehabilitation has the potential to improve upper limb recovery in people with moderate-to-severe disability from multiple sclerosis. Sharing standard definitions and components of feedback and serious game in technologically assisted upper limb rehabilitation is necessary to enhance the effectiveness of training.
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Article
Rehabilitation
Mauro Mancuso, Marco Iosa, Laura Abbruzzese, Alessandro Matano, Michela Coccia, Silvia Baudo, Adonella Benedetti, Carmen Gambarelli, Simona Spaccavento, Giordano Ambiveri, Marisa Megna, Paola Tognetti, Alessandra Maietti, Maria L. Rinaldesi, Giulia Gamberini, Valentina Varalta, Giovanni Morone, Irene Ciancarelli
Summary: This study aimed to evaluate the relationships between impairments in cognitive functions and recovery of functional independence in stroke patients during the subacute phase. The results identified several predictors of functional recovery, including functional status, lower limb functioning, attention, and executive functions. Patients who recovered deficits in executive functions had the same recovery as those without deficits, while those who maintained deficits had a smaller recovery.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Article
Clinical Neurology
Giuseppe Ventriglia, Fabrizio Gervasoni, Massimiliano Franco, Alberto Magni, Giorgio Panico, Giovanni Iolascon
Summary: The survey examines the knowledge, attitude, and practices of general practitioners, physiatrists, and sports medicine doctors regarding thermotherapy for musculoskeletal pain. The results show that there are differences in prescribing habits between general practitioners and specialists, but there is a general consensus on the benefits of thermotherapy in managing musculoskeletal disorders.
JOURNAL OF PAIN RESEARCH
(2023)
Review
Medicine, General & Internal
Mirjam Bonanno, Angela Militi, Francesca La Fauci Belponer, Rosaria De Luca, Danilo Leonetti, Angelo Quartarone, Irene Ciancarelli, Giovanni Morone, Rocco Salvatore Calabro
Summary: Cerebral palsy (CP) is a congenital and permanent neurological disorder that affects gross motor functions. Robotic devices, with their biomechanical features, can easily adapt to CP children and provide better motor recovery and enjoyment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Aurore Thibaut, Felipe Fregni, Anna Estraneo, Salvatore Fiorenza, Enrique Noe, Roberto Llorens, Joan Ferri, Rita Formisano, Giovanni Morone, Andreas Bender, Martin Rosenfelder, Gianfranco Lamberti, Ekaterina Kodratyeva, Sergey Kondratyev, Liudmila Legostaeva, Natalia Suponeva, Carmen Krewer, Friedemann Mueller, Nadia Dardenne, Haroun Jedidi, Steven Laureys, Olivia Gosseries, Nicolas Lejeune, Geraldine Martens
Summary: This study found that transcranial direct current stimulation (tDCS) does not enhance patients' recovery during rehabilitation. However, the response to the treatment seems to be influenced by patients' diagnosis and aetiology.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Engineering, Biomedical
Amaranta Soledad Orejel Bustos, Marco Tramontano, Giovanni Morone, Irene Ciancarelli, Giuseppe Panza, Andrea Minnetti, Alessandro Picelli, Nicola Smania, Marco Iosa, Giuseppe Vannozzi
Summary: Monitoring systems at home are critical for fall detection and can range from standalone devices to activity recognition devices. This review analyzes the current literature on different devices for home fall detection. The studies highlight the importance of fall detection at home and the potential of machine learning algorithms in predicting falls.
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Review
Medicine, Research & Experimental
Antimo Moretti, Giovanni Iolascon
Summary: Sclerostin, encoded by the SOST gene, is an important regulator of bone homeostasis by inhibiting the Wnt signaling pathway. Recent studies have also suggested a potential role of sclerostin in myogenesis, affecting the interaction between bone and muscle. This review provides an overview of the clinical implications of sclerostin modulation on skeletal muscle mass and function, and bone metabolism. Understanding the muscle-bone crosstalk may have significant implications for the development of therapeutic strategies for musculoskeletal disorders, particularly osteosarcopenia.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Health Care Sciences & Services
William Raffaeli, Giorgio Felzani, Michael Tenti, Luca Greco, Maria Pia D'Eramo, Stefania Proietti, Giovanni Morone
Summary: This study aimed to investigate the effect of NACVAN (R) as an adjuvant treatment to gabapentinoids on pain symptomatology in CNP patients. Preliminary results showed significant reductions in pain intensity, neuropathic symptoms, and evoked pain with NACVAN (R) treatment, while other neuropathic pain dimensions and quality-of-life did not significantly improve.
Article
Geriatrics & Gerontology
Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Eleonora Sparvieri, Domiziano Tarantino, Luigi Ferrucci
Summary: The study finds that the collagen turnover marker P3NP is associated with changes in muscle density and physical performance. Participants with lower P3NP levels perform better in terms of muscle density and physical performance and have a lower risk of developing chronic degenerative age-related diseases. The interaction between P3NP and factors such as leptin, muscle density, and fat mass affects muscle density and physical performance.
Review
Rheumatology
Giuseppe Toro, Antonio Benedetto Cecere, Adriano Braile, Annalisa De Cicco, Sara Liguori, Umberto Tarantino, Giovanni Iolascon
Summary: High Energy Musculoskeletal Traumas (HEMTs) are a significant problem for healthcare systems due to high social costs, and the high morbidity and mortality. Complications such as bone infection, fracture malunion, and non-union contribute to poor outcomes associated with HEMT. Treatment of these complications can be challenging, with limb reconstruction often requiring multiple procedures. Amputation may theoretically offer better function and lower complications, but also comes with its own set of complications and long-term social costs. A comprehensive literature review was conducted to propose ways to optimize limb preservation surgeries for HEMT complications and improve their management.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Rheumatology
Antimo Moretti, Sara Liguori, Marco Paoletta, Silvia Migliaccio, Giuseppe Toro, Francesca Gimigliano, Giovanni Iolascon
Summary: Bone fragility is associated with aging, comorbidities, disability, poor quality of life, and increased mortality. International guidelines recommend a nutritional approach for managing patients with bone fragility, focusing on optimal protein, calcium, and vitamin D intake. Patients with major fragility fractures often have poor dietary habits and lack intake of nutrients that affect bone health, which can be further worsened during the COVID-19 pandemic. This narrative review discusses the role of macro- and micronutrients in patients with bone fragility during this pandemic.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Rheumatology
Maria Chiara Massari, Viviana Maria Bimonte, Lavinia Falcioni, Antimo Moretti, Carlo Baldari, Giovanni Iolascon, Silvia Migliaccio
Summary: 'Frailty' is a state of increased vulnerability caused by impairment of homeostasis due to stress. Frail individuals are more likely to experience significant health decline and have a higher risk of adverse outcomes such as osteoporosis, falls, and disability. Frailty is becoming increasingly important due to global population aging. The pathophysiology of frailty involves cumulative molecular and cellular damage and is partially independent of aging but closely related. Uncorrected nutrition and sedentary behavior worsen frailty.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Rheumatology
Alberto Migliore, Liudmila Alekseeva, Sachin R. Avasthi, Raveendhara R. Bannuru, Xavier Chevalier, Thierry Conrozier, Sergio Crimaldi, Gustavo C. de Campos, Demirhan Diracoglu, Gianfranco Gigliucci, Gabriel Herrero-Beaumont, Giovanni Iolascon, Ruxandra Ionescu, Joerg Jerosch, Jorge Lains, Emmanuel Maheu, Souz Makri, Natalia Martusevich, Marco Matucci-Cerinic, Karen Pavelka, Robert J. Petrella, Raghu Raman, Umberto Tarantino
Summary: The lack of a validated definition of early osteoarthritis (EOA) hinders early diagnosis and effective therapeutic strategies. Therefore, the development of a specific questionnaire to evaluate and monitor the clinical progress of patients with early knee OA is essential.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Rheumatology
Giuseppe Toro, Adriano Braile, Sara Liguori, Antimo Moretti, Giovanni Landi, Antonio Benedetto Cecere, Gianluca Conza, Annalisa De Cicco, Umberto Tarantino, Giovanni Iolascon
Summary: Osteoporosis and fragility fractures are critical health problems that can lead to high morbidity, mortality, and healthcare costs. Fracture liaison service has shown to reduce fracture risk and improve patient adherence to treatment, but long-term and high adherence to medications may result in atypical fractures. A comprehensive and interdisciplinary approach involving a dedicated healthcare team can improve the standard of care.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Medicine, General & Internal
Dalila Scaturro, Antimo Moretti, Fabio Vitagliani, Giuliana Guggino, Sofia Tomasello, Davide Lo Nardo, Lorenza Lauricella, Giovanni Iolascon, Giulia Letizia Mauro
Summary: Combined treatment with manual therapy and ultrasound therapy appears to be useful in the management of ischemic digital ulcers in patients with systemic sclerosis.
MEDICINA-LITHUANIA
(2023)
