Prepare for the Future: Dissecting the Spike to Seek Broadly Neutralizing Antibodies and Universal Vaccine for Pandemic Coronaviruses

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

(2020) Pavlo Gilchuk et al.   IMMUNITY

The protective potential of Fc‐mediated antibody functions against influenza virus and other viral pathogens

(2020) Hillary A Vanderven et al.   IMMUNOLOGY AND CELL BIOLOGY

Is COVID-19 receiving ADE from other coronaviruses?

(2020) Jason A. Tetro   MICROBES AND INFECTION

Covid-19 — Navigating the Uncharted

(2020) Anthony S. Fauci et al.   NEW ENGLAND JOURNAL OF MEDICINE

The costs of secrecy

(2020) H. Holden Thorp   SCIENCE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Broadly Protective Strategies Against Influenza Viruses: Universal Vaccines and Therapeutics

(2020) Olivia A. Vogel et al.   Frontiers in Microbiology

Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention

(2020) Kathryn E. Stephenson et al.   Annual Review of Immunology

A Vaccine against Ebola Virus

(2020) Erica Ollmann Saphire   CELL

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

A Genomic Perspective on the Origin and Emergence of SARS-CoV-2

(2020) Yong-Zhen Zhang et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

(2020) Shuai Xia et al.   CELL RESEARCH

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

(2020) Tao Zhang et al.   CURRENT BIOLOGY

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)

(2020) James M. Sanders et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Forty years with coronaviruses

(2020) Susan R. Weiss   JOURNAL OF EXPERIMENTAL MEDICINE

Will COVID-19 generate global preparedness?

(2020) Kathryn H Jacobsen   LANCET

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

(2020) Dora Pinto et al.   NATURE

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

Developing Covid-19 Vaccines at Pandemic Speed

(2020) Nicole Lurie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Better late than never

(2020) H. Holden Thorp   SCIENCE

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

(2020) Meng Yuan et al.   SCIENCE

A human monoclonal antibody blocking SARS-CoV-2 infection

(2020) Chunyan Wang et al.   Nature Communications

Covid-19: FDA approves use of convalescent plasma to treat critically ill patients

(2020) Janice Hopkins Tanne   BMJ-British Medical Journal

Lessons learned from Zaire ebolavirus to help address urgent needs for vaccines against Sudan ebolavirus and Marburg virus

(2020) Daniel N. Wolfe et al.   Human Vaccines & Immunotherapeutics

Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in hemagglutinin globular head

(2020) Yulu Wang et al.   Frontiers of Medicine

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains

(2019) Hannah L. Turner et al.   PLOS BIOLOGY

Achieving cross-reactivity with pan-ebolavirus antibodies

(2019) Liam B King et al.   Current Opinion in Virology

Structural basis of broad ebolavirus neutralization by a human survivor antibody

(2019) Brandyn R. West et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ebola virus disease

(2019) Denis Malvy et al.   LANCET

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

(2019) Alexandra C. Walls et al.   CELL

Protein and Glycan Mimicry in HIV Vaccine Design

(2019) Gemma E. Seabright et al.   JOURNAL OF MOLECULAR BIOLOGY

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

(2019) Shuai Xia et al.   Science Advances

New antibody-based prevention and treatment options for influenza

(2019) Koen Sedeyn et al.   ANTIVIRAL RESEARCH

The Quest for a Truly Universal Influenza Vaccine

(2019) Yo Han Jang et al.   Frontiers in Cellular and Infection Microbiology

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry

(2019) Yushun Wan et al.   JOURNAL OF VIROLOGY

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

(2019) Sabue Mulangu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

(2019) Qian Wang et al.   Frontiers of Medicine

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein

(2018) Pavlo Gilchuk et al.   IMMUNITY

Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2–MPER region

(2018) Andrew I. Flyak et al.   Nature Microbiology

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

(2018) Erica Ollmann Saphire et al.   CELL

Native-like Env trimers as a platform for HIV-1 vaccine design

(2017) Rogier W. Sanders et al.   IMMUNOLOGICAL REVIEWS

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

(2017) Yuan Yuan et al.   Nature Communications

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

(2016) Nicole L. Kallewaard et al.   CELL

Novel universal influenza virus vaccine approaches

(2016) Florian Krammer   Current Opinion in Virology

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Human Monoclonal Antibodies against Highly Conserved HR1 and HR2 Domains of the SARS-CoV Spike Protein Are More Broadly Neutralizing

(2012) Hatem A. Elshabrawy et al.   PLoS One

Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

(2010) Jeffery K. Taubenberger et al.   Cell Host & Microbe

Vaccine-induced enhancement of viral infections

(2008) W. Huisman et al.   VACCINE