Review
Infectious Diseases
Javier Cobo, Rosa Escudero-Sanchez
Summary: The treatment of prosthetic joint infections (PJIs) is a complex matter that requires integration of surgical, microbiological, and pharmacological aspects, while also taking into consideration each patient's individual context. In some cases, curative treatment may not be possible, leading to the importance of long-term antibiotic administration to suppress the infection.
Review
Immunology
Nicolas Cortes-Penfield, Martin Krsak, Laura Damioli, Michael Henry, Jessica Seidelman, Angela Hewlett, Laura Certain
Summary: This narrative review synthesizes the literature on the role of suppressive antibiotic therapy (SAT) to prevent treatment failure after debridement, antibiotics, and implant retention (DAIR) for prosthetic joint infection. It aims to answer three key questions: (1) the identification of patients at highest risk for treatment failure after DAIR, (2) the effectiveness of SAT in reducing treatment failure rate after DAIR, and (3) the rates of treatment failure and adverse events in patients receiving SAT. The review proposes risk-benefit stratification criteria for selecting patients for SAT following DAIR.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Osakpolor Ogbebor, Tatum D. Mortimer, Kyra Fryling, Jessica J. Zhang, Nitin Bhanot, Yonatan H. Grad
Summary: The study reports a case of disseminated gonococcal infection involving a prosthetic joint, and utilizes whole-genome sequencing to identify resistance genes, potential virulence factors, and the phylogenetic lineage of the infecting isolate. The research calls for routine sequencing and reporting of invasive gonococcal infections to accelerate understanding of genetic features contributing to pathogenesis.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Orthopedics
Rebecca G. Burr, Carlo K. Eikani, William H. Adams, William J. Hopkinson, Nicholas M. Brown
Summary: Chronic antibiotic suppression (CAS) is a reasonable treatment strategy for patients with persistent prosthetic joint infection (PJI) or multiple comorbidities. This study found that multiple changes to antibiotic regimen may lead to treatment failure in CAS, while total hip arthroplasty patients and patients with Gram-positive infections were less likely to require reoperation. The results of this study provide guidance for selecting appropriate treatment options for PJI patients.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Infectious Diseases
Michela Padovani, Anna Bertelli, Silvia Corbellini, Giorgio Piccinelli, Francesca Gurrieri, Maria Antonia De Francesco
Summary: This study evaluated the activity of the antimicrobial agent Cefiderocol against a range of pathogens and analyzed the resistance mechanism in two resistant Klebsiella pneumoniae isolates. The results demonstrated good effectiveness of Cefiderocol against most pathogens, but with a higher resistance rate observed. Active surveillance is necessary to control the spread of these pathogens and prevent the emergence of resistance to new drugs.
Article
Orthopedics
Bryan D. Springer, Larry M. Baddour, Peter B. Lockhart, Martin H. Thornhill
Summary: The study found no significant positive association between invasive dental procedures (IDPs) and late periprosthetic joint infections (LPJIs). Therefore, there is no rationale to administer antibiotic prophylaxis (AP) before IDPs in patients with prosthetic joints, considering the cost and inconvenience of AP, the risk of adverse drug reactions, and the potential for unnecessary use of AP that promotes antibiotic resistance. Dental care should focus on maintaining good oral hygiene rather than recommending AP for IDPs.
JOURNAL OF ARTHROPLASTY
(2022)
Review
Pharmacology & Pharmacy
Mohammad Abavisani, Reza Khayami, Melika Hoseinzadeh, Mansoor Kodori, Prashant Kesharwani, Amirhossein Sahebkar
Summary: The increasing global trends of antibiotic resistance (AR) and its destructive impact on patients and healthcare systems underscore the need for new strategies. Understanding bacterial resistance mechanisms and accurate diagnosis can enhance the effectiveness of novel strategies. The transfer of antimicrobial resistance genes (ARGs) is a significant factor in disseminating AR. The CRISPR-Cas system, as part of the bacterial immune system, shows promise in removing ARGs and presents an innovative strategy in the battle against antibiotic resistance.
DRUG RESISTANCE UPDATES
(2023)
Review
Immunology
Ailing Zhao, Jiazheng Sun, Yipin Liu
Summary: Bacterial biofilms are complex microbial communities surrounded by extracellular polymeric substances. They are a significant problem in treating bacterial infections and can exhibit increased resistance to antibiotics, causing device-related and non-device infections and posing a serious threat to global health. Therefore, early detection and search for new treatments are essential. This paper systematically reviews the formation, infections, detection methods, and potential treatment strategies of bacterial biofilms, aiming to provide researchers with the latest progress in their detection and treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Editorial Material
Immunology
Ana Paula Streling, Mohanad M. Al Obaidi, William D. Lainhart, Tirdad Zangeneh, Ayesha Khan, An Q. Dinh, Blake Hanson, Cesar A. Arias, William R. Miller
Summary: A study reported the emergence of non-susceptibility to cefiderocol in a subpopulation of Pseudomonas aeruginosa recovered from a patient without prior exposure to the antibiotic. Whole genome sequencing revealed mutations in major iron transport pathways linked to cefiderocol uptake, highlighting the importance of susceptibility testing before therapy with siderophore cephalosporins.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Martin H. Thornhill, Annabel Crum, Saleema Rex, Tony Stone, Richard Campbell, Mike Bradburn, Veronica Fibisan, Peter B. Lockhart, Bryan Springer, Larry M. Baddour, Jon Nicholl
Summary: This study investigated the temporal association between invasive dental procedures (IDP) and late prosthetic joint infection (LPJI) in England, where antibiotic prophylaxis has never been recommended for LPJI prevention, and found no significant association between IDP and subsequent LPJI, suggesting that administering antibiotic prophylaxis before IDP in patients with prosthetic joints may not be necessary.
Article
Microbiology
Katherine M. C. Totten, Robin Patel
Summary: This study examined the activity of seven phages against 122 clinical isolates of Staphylococcus aureus causing periprosthetic joint infection (PJI). The results demonstrated that phages were active against both planktonic and biofilm phenotypes of bacteria, suggesting their potential as an alternative or adjunct to antibiotics for the treatment of PJI.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Nanoscience & Nanotechnology
Zhidong Zhou, Mingxuan Kai, Shuyan Wang, Dan Wang, Yifei Peng, Yiyan Yu, Weiwei Gao, Liangfang Zhang
Summary: The rise of antibiotic resistance has led to the search for novel and effective antibacterial therapeutics in nanomedicine. The first-generation antibacterial nanoparticles have improved drug tolerability, circulation half-life, and efficacy. Researchers are now focusing on developing next-generation antibacterial nanoparticles with design elements emphasizing physical, broad-spectrum, biomimetic, and antivirulence mechanisms. This review highlights four emerging designs: inorganic antibacterial nanoparticles, responsive antibacterial nanocarriers, virulence nanoscavengers, and antivirulence nanovaccines, which provide new approaches for overcoming antibiotic resistance and achieving more effective antibacterial therapy.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Aerospace
Chongzhen Wang, Wanlin Xing, Fan Lu
Summary: This article summarizes previous investigations on the effects of microgravity on bacterial virulence, infection, and antibiotic resistance. The results show that microgravity can enhance or attenuate the virulence of certain bacterial strains, mitigate or exacerbate the severity of infection, and enhance or attenuate antibiotic resistance. The limitations of previous studies are discussed, and the need for future research is emphasized.
Article
Infectious Diseases
Konstantinos Anagnostakos, Christoph Grzega, Ismail Sahan, Udo Geipel, Soren L. Becker
Summary: A retrospective analysis found that a small percentage of periprosthetic infections in hip and knee joints were caused by rare pathogens with varying antibiotic resistance profiles, highlighting the importance of interdisciplinary collaboration between orthopedic surgeons and clinical microbiologists in selecting appropriate treatment regimens.
Article
Immunology
Lee-Jung Tak, Min-Kyoung Shin, Jun-Il Yoo, Min-Chul Cho, Wanil Kim
Summary: Early detection of periprosthetic joint infection (PJI) is crucial for proper treatment. This study developed a droplet digital PCR (ddPCR)-based detection method for bacterial pathogens in PJI and demonstrated its potential to decrease microbial detection limit and provide precise detection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Laura Dabos, Joanna E. Raczynska, Pierre Bogaerts, Agustin Zavala, Delphine Girlich, Remy A. Bonnin, Laurent Dortet, Aurelie Peyrat, Pascal Retailleau, Bogdan I. Iorga, Mariusz Jaskolski, Youri Glupczynski, Thierry Naas
Summary: OXA-48-producing Enterobacterales have disseminated globally, with several variants reported, differing by a few amino acid substitutions or deletions, mostly in the /35-/36 loop region. OXA-517, a natural variant of OXA-48, with an Arg214Lys substitution and a deletion in the β5-β6 loop, has the ability to hydrolyze extended-spectrum cephalosporins and carbapenems. This study highlights the remarkable ability of OXA-48-like carbapenemases to evolve through mutation/deletion in the β5-β6 loop to expand their hydrolysis spectrum.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Letter
Infectious Diseases
Sandrine Bernabeu, Remy A. Bonnin, Laurent Dortet
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Agnes B. Jousset, Sandrine Bernabeu, Cecile Emeraud, Remy A. Bonnin, Alexandra Lomont, Jean Ralph Zahar, Audrey Merens, Christophe Isnard, Nathalie Soismier, Eric Farfour, Vincent Fihman, Nicolas Yin, Olivier Barraud, Herve Jacquier, Anne-Gaelle Ranc, Frederic Laurent, Stephane Corvec, Louise Ruffier d'Epenoux, Emmanuelle Bille, Nicolas Degand, Chloe Plouzeau, Thomas Guillard, Vincent Cattoir, Asaf Mizrahi, Antoine Grillon, Frederic Janvier, Cecile Le Brun, Marlene Amara, Mathilda Bastide, Alban Lemonnier, Laurent Dortet
Summary: This study aimed to provide susceptibility data on a large series of Enterobacterales since the revision of EUCAST categorization break-points in 2020. The results showed that Ceftolozane-tazobactam (C/T) had a susceptibility rate of 88% in Enterobacterales infections, with higher susceptibility in 3GC-resistant strains and lower susceptibility in CRE strains. This prospective study highlights the importance of C/T in the treatment of infections.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Article
Infectious Diseases
Remy A. Bonnin, Sandrine Bernabeu, Cecile Emeraud, Thierry Naas, Delphine Girlich, Agnes B. Jousset, Laurent Dortet
Summary: This study demonstrated the high in vitro efficacy of ceftazidime/avibactam, imipenem/relebactam, and to a lesser extent meropenem/vaborbactam against carbapenem-resistant non-carbapenemase-producing Enterobacterales. Testing all beta-lactam/beta-lactamase inhibitor combinations is crucial for carbapenem-resistant Enterobacterales (CRE) as resistance to one combination does not predict resistance to another, depending on the resistance mechanisms involved.
Letter
Infectious Diseases
Agnes B. Jousset, Corentin Poignon, Seher Yilmaz, Alexandre Bleibtreu, Cecile Emeraud, Delphine Girlich, Thierry Naas, Jerome Robert, Remy A. Bonnin, Laurent Dortet
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Laurent Dortet, Claudia Niccolai, Niels Pfennigwerth, Stefanie Frisch, Camille Gonzalez, Alberto Antonelli, Tommaso Giani, Robert Hoenings, Soeren Gatermann, Gian Maria Rossolini, Thierry Naas
Summary: In this study, the clinical performance of Bruker's UMIC (R) Cefiderocol method for determining the minimum inhibitory concentration (MIC) of Cefiderocol in clinically relevant bacteria was assessed. The results showed good agreement between the UMIC (R) Cefiderocol method and the reference method, indicating its suitability for determining Cefiderocol MIC values.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Rita Elias, Anton Spadar, Antoni P. A. Hendrickx, Remy A. Bonnin, Laurent Dortet, Margarida Pinto, Jody E. Phelan, Isabel Portugal, Susana Campino, Gabriela Jorge da Silva, Taane G. Clark, Aida Duarte, Joao Perdigao
Summary: This study characterized the genomic diversity and international dissemination of CRKP strains from tertiary care hospitals in Lisbon, Portugal. Two genomic clusters, ST13/GC1 and ST17/GC2, were identified. Additionally, an emerging OXA-181/ST17-producing strain in Portugal and the ongoing international dissemination of a KPC-3/ST13-producing clone were highlighted.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Editorial Material
Infectious Diseases
Delphine Girlich, Cecile Emeraud, Oceane Vanparis, Thierry Naas, Remy A. Bonnin, Laurent Dortet
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Editorial Material
Microbiology
Raffaele Zarrilli, Tommaso Giani, Remy A. Bonnin
Article
Infectious Diseases
Lydia Galvez-Benitez, Jose Manuel Ortiz de la Rosa, Angel Rodriguez-Villodres, Carlos S. Casimiro-Soriguer, Irene Molina-Panadero, Rocio Alvarez-Marin, Remy A. Bonnin, Thierry Naas, Jeronimo Pachon, Jose Miguel Cisneros, Jose Antonio Lepe, Younes Smani
Summary: This study aimed to identify the mechanisms underlying Piperacillin-tazobactam resistance (P/T-R) in Escherichia coli. The results showed that P/T-R isolates had a higher copy number of the bla(TEM) gene, generated by three different genetic events. In addition, reduced expression of OmpC was observed in two P/T-R strains. This study provides important insights into the acquisition of P/T-R in E. coli, which is crucial for effective treatment and prevention of resistant microorganisms.
JOURNAL OF INFECTION
(2023)
Article
Microbiology
Laura Biez, Remy A. Bonnin, Cecile Emeraud, Aurelien Birer, Agnes B. Jousset, Thierry Naas, Laurent Dortet
Summary: This study analyzed the largest collection of carbapenemase-producing Citrobacter spp. and revealed the molecular epidemiology of Citrobacter spp. in France.
