期刊
MICROORGANISMS
卷 8, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms8091300
关键词
biofilm; Candida albicans; endodontics; intraradicular eradication; pathogenicity; persistent infection; virulence factors
类别
资金
- Korea Health TechnologyR&DProject through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health Welfare [HI17C1377]
Candida albicans (C. albicans) is the fungus most frequently isolated from endodontic root canal infections. Although recognized by dental pulp and periradicular tissue cells that elicit immune responses, it eludes host defenses and elicits cell death. Then, C. albicans binds tooth dentin, forms biofilms, and invades dentinal tubules to resist intracanal disinfectants and endodontic treatments. Insensitive to most common medicaments, it survives sequestered within biofilms and intratubular dentin. Thus, C. albicans has been associated with cases of persistent or refractory root canal infections. Its treatment strategies may require alternative intracanal irrigants, intracanal medicaments such as chlorhexidine gel or human beta defensin-3 (HBD3), Ca-Si-based obturating materials, and microsurgical procedures.
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