Review
Physiology
Salma Sultan, Mohammed El-Mowafy, Abdelaziz Elgaml, Tamer A. E. Ahmed, Hebatoallah Hassan, Walid Mottawea
Summary: Inflammatory bowel diseases are chronic medical disorders characterized by recurrent gastrointestinal inflammation, with the main etiology being the dysregulation of gut microbiota and host immune system. The dysbiosis of gut microbiota may contribute to inflammation by affecting the immune system or metabolic pathways, while host metabolic defectiveness also adds to the risk of disease progression. Therapeutic approaches targeting the gut microbiome may hold promise for the management of IBD.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Microbiology
Yanbo Liu, Zhen Li, Tianning Sun, Zhigang He, Hongbing Xiang, Jun Xiong
Summary: Neurocognitive disorders are complex and multifactorial diseases, where the 5-hydroxytryptamine neuron system plays an important role. Previous studies have shown that 5-hydroxytryptamine scavengers can negatively affect cognitive function and potentially lead to neurocognitive disorders through other pathways. Behavioral tests on mice treated with a 5-hydroxytryptamine scavenger showed cognitive dysfunction and depression-like behavior. Dysbiosis and acetate alternation were found to be related to the development of neurocognitive disorders induced by the 5-hydroxytryptamine scavenger.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Endocrinology & Metabolism
Maria Jose Mendoza-Leon, Ashutosh K. Mangalam, Alejandro Regaldiz, Enrique Gonzalez-Madrid, Ma. Andreina Rangel-Ramirez, Oscar Alvarez-Mardonez, Omar P. Vallejos, Constanza Mendez, Susan M. Bueno, Felipe Melo-Gonzalez, Yorley Duarte, Ma. Cecilia Opazo, Alexis M. Kalergis, Claudia A. Riedel
Summary: Thyroid disorders are characterized by changes in T-4, T-3 and TSH levels in the blood, affecting cell differentiation, function, and metabolism. Factors such as iodine intake, environmental contamination, smoking, drugs, and genetics increase susceptibility to these diseases. The intestinal microbiota and their production of short-chain fatty acids have been linked to thyroid disorders, making it an important area of research for endocrinologists.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Liyun Liu, Mingchao Xu, Ruiting Lan, Dalong Hu, Xianping Li, Lei Qiao, Suping Zhang, Xiaoying Lin, Jing Yang, Zhihong Ren, Jianguo Xu
Summary: B. vulgatus Bv46 can significantly alleviate DSS-induced colitis symptoms, modify the gut microbiota community, reduce the expression levels of inflammatory factors, and increase the content of fecal SCFAs, especially butyric acid and propionic acid, showing promising potential for colitis prevention.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Qin Zhang, Wen-mu Hu, Yu-ling Deng, Jin-jing Wan, Yu-jun Wang, Ping Jin
Summary: This study found that gut microbiota dysbiosis and decreased propionic acid levels were observed in patients with Cushing's syndrome, which may be one of the causes of metabolic abnormalities. Therefore, the gut microbiota may serve as a potential therapeutic target to improve hypercortisolism-related metabolic abnormalities.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Microbiology
Weiping Xiao, Jiabin Su, Xinjie Gao, Heng Yang, Ruiyuan Weng, Wei Ni, Yuxiang Gu
Summary: This study demonstrates that modulating the gut microbiome via fecal microbiota transplantation (FMT) can improve cognitive impairment and depressive-like behaviors caused by chronic cerebral hypoperfusion. FMT increases the level of short-chain fatty acids (SCFAs), promotes gut function, and improves cognitive performance. Long-term SCFA supplementation also reduces inflammation and hippocampal neuronal apoptosis.
Article
Immunology
Hao Liu, Yuxi Cheng, Yidan Qu, Guohao Wu
Summary: This study establishes a cachexia mouse model and explores the connection between gut microbiota and short-chain fatty acids in cachexia. The findings provide fundamental insights into the regulatory mechanisms and potential therapeutic strategies for cancer cachexia.
MICROBIAL PATHOGENESIS
(2023)
Article
Nutrition & Dietetics
Karley K. Mahalak, Jamshed Bobokalonov, Jenni Firrman, Russell Williams, Bradley Evans, Brian Fanelli, Jason W. Soares, Masuko Kobori, LinShu Liu
Summary: In this study, we found that regular consumption of capsaicin can change the structure of the gut microbial community and increase the abundance of certain short-chain fatty acids, particularly butanoic acid. These changes may be responsible for the health benefits associated with capsaicin consumption.
Article
Food Science & Technology
Chen Chen, Chenglong Liu, Ke Zhang, Wentong Xue
Summary: Emerging evidence suggests that abnormal changes in gut microbiota are associated with the increasing prevalence of food allergies. The dysbiosis of gut microbiota disrupts the balance of the immune system and promotes the occurrence of food allergies. Recent research indicates that short-chain fatty acids (SCFAs), which are metabolites derived from gut microbiota, play a protective role in food allergies. This comprehensive review discusses the relationship between gut microbiota and food allergies, as well as the mechanisms by which gut microbiota composition and metabolites regulate various cellular pathways in the immune system. These findings highlight the positive function of gut microbiota in food allergies and provide novel insights for future treatment or prevention strategies.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Microbiology
Zhen Chen, Qingqing Xu, Yang Liu, Yihan Wei, Shancai He, Wei Lin, Yingge Wang, Li Li, Yuanteng Xu
Summary: This study found that gut microbiota dysbiosis increased susceptibility and severity of allergic rhinitis, which is significantly related to reduced SCFA-producing bacteria, fecal SCFAs, and specific bacterial taxa. Treatment with sodium butyrate significantly reduced levels of total IgE, OVA-sIgE, IL-4, and IL-5 in serum, and improved inflammation infiltration in nasal and colon mucosa.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Benchi Cai, Lifan Zhong, Qitong Wang, Wendi Xu, Xi Li, Tao Chen
Summary: This study investigates the neuroprotective mechanisms of curcumin for Parkinson's disease through the microbiota-gut-brain axis, and finds that curcumin alleviates motor deficits and gut dysfunctions by regulating the gut microbiota and short-chain fatty acids.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Lin Xiao, Qin Liu, Mei Luo, Lishou Xiong
Summary: Research has identified the significant roles that microbiota-derived metabolites play in the development of IBS symptoms in patients, shedding light on the complex interplay between gut microbiota and IBS.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Xiao-Chen Liu, Qian Sun, Yan-Chun Ji, Li-Zhen Fu, Zheng-Li Wang, Yu He, Lu-Quan Li
Summary: There are variations in gut microbiota compositions, short-chain fatty acids concentrations, and autoinducer-2 levels in very-low-birth-weight (VLBW) infants. Some short-chain fatty acids and autoinducer-2 have moderate predictive value for feeding intolerance (FI).
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Yangyang Li, Yiming Zhang, Kongxi Wei, Jinpeng He, Nan Ding, Junrui Hua, Ting Zhou, Fan Niu, Gucheng Zhou, Tongfan Shi, Liying Zhang, Yongqi Liu
Summary: Gut microbiota, regarded as the second human genome, plays a crucial role in host health and intestinal homeostasis. Radiotherapy-induced dysbiosis of gut microbiota can lead to changes in harmful and beneficial bacteria, affecting disease states, particularly intestinal diseases. Metabolites produced by gut microbiota, such as SCFAs, serve as important messengers in signal transduction and disease development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Cameron Martino, Livia S. Zaramela, Bei Gao, Mallory Embree, Janna Tarasova, Seth J. Parker, Yanhan Wang, Huikuan Chu, Peng Chen, Kuei-Chuan Lee, Daniela Domingos Galzerani, Jivani M. Gengatharan, Asama Lekbua, Maxwell Neal, Rob Knight, Hidekazu Tsukamoto, Christian M. Metallo, Bernd Schnabl, Karsten Zengler
Summary: Liver damage due to chronic alcohol use is a common liver disease. This study investigated the metabolic impacts of alcohol consumption on the gut microbiota using isotope-labeled ethanol, metagenomics, and metatranscriptomics. The results showed that ethanol is not directly metabolized by the gut microbiota, but changes in the microbiota are a side effect of elevated acetate levels. Understanding these changes is important for understanding alcohol-related liver disease.
NATURE COMMUNICATIONS
(2022)
Article
Nursing
Maureen W. Groer, Elizabeth M. Miller, Amy D'Agata, Thao T. B. Ho, Samia V. Dutra, Ji Youn Yoo, Alyson L. Yee, Jack A. Gilbert, Larry J. Dishaw
JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING
(2020)
Article
Nutrition & Dietetics
Maureen Groer, Elizabeth M. Miller, Anujit Sarkar, Larry J. Dishaw, Samia Dutra, Ji Youn Yoo, Katherine Morgan, Ming Ji, Thao Ho
Review
Medicine, General & Internal
Anujit Sarkar, Ji Youn Yoo, Samia Valeria Ozorio Dutra, Katherine H. Morgan, Maureen Groer
Summary: The gut microbiota in early life plays a crucial role in human health and diseases, influenced by factors including gestational age, delivery mode, birth weight, feeding types, antibiotic exposure, maternal microbiome, and diet. These microbes assist in digestion, immune regulation, and disease risk modulation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Justin Gibbons, Ji Youn Yoo, Tina Mutka, Maureen Groer, Thao T. B. Ho
Summary: The study demonstrates the importance of intestinal microbiota in preterm infants' health and disease, using an in vitro cell model to study the interactions between gut flora and epithelial cells. Inflammatory responses were found to be correlated with the ratio of Proteobacteria to Firmicutes and fecal bacterial genera. The model has the potential to be further developed for studying the impact of different microbial flora on epithelial cells of preterm infants.
Article
Microbiology
Ji Youn Yoo, Sarah Sniffen, Kyle Craig McGill Percy, Veera Bramhachari Pallaval, Bojjibabu Chidipi
Summary: Atherosclerosis, a major cause of cardiovascular disease, can be influenced by alterations in the gut microbiota composition, leading to gut dysbiosis. This dysbiosis activates immune processes and systemic inflammation, contributing to the development of atherosclerotic cardiovascular disease (ACVD). The gut microbiota produces metabolites, such as trimethylamine (TMA) and short-chain fatty acids (SCFAs), that can either promote or decrease atherogenesis. Understanding the relationship between the gut microbiota and the host immune system could provide insights into ACVD development, prognostic factors, and potential treatments.
Article
Developmental Biology
Anujit Sarkar, Stephanie M. Prescott, Samia Dutra, Ji Youn Yoo, Jessica Gordon, Emily Shaffer, Daniel McSkimming, Maureen E. Groer
Summary: The gut microbiome of very low birth weight infants in the neonatal intensive care unit (NICU) is associated with early cognitive and behavioral neurodevelopment.
DEVELOPMENTAL PSYCHOBIOLOGY
(2022)
Review
Infectious Diseases
Fen Zhang, Dominik Aschenbrenner, Ji Youn Yoo, Tao Zuo
Summary: The gut mycobiome is a crucial component of the gut microbiome that regulates host homeostasis, physiological processes, and the assembly of the gut bacterial microbiome. Understanding its composition and functional diversity is important for studying health and diseases, as well as developing microbiome-based therapies.
Article
Obstetrics & Gynecology
Tina Mutka, Andreas Seyfang, Ji Youn Yoo, Samia Valeria Ozorio Dutra, Ming Ji, Adetola Louis-Jacques, Karen Bruder, Stephanie Prescott, Kami Kim, Maureen Groer
Summary: This study investigated the pregnancy outcomes of women with chronic Toxoplasma gondii infection, and found that compared to the control group without infection, women with chronic T. gondii infection had a higher proportion of adverse pregnancy outcomes, but the specific mechanism is still unknown.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Education & Educational Research
Samia Valeria Ozorio Dutra, Vanessa Chee, Keith Weeks, David Pontin, John M. Clochesy
Summary: This study explored the adaptability of safeMedicate for use in Brazil through a qualitative design process. The findings suggest that safeMedicate is acceptable in Brazil and can help address the gaps in teaching and practice.
EDUCATION SCIENCES
(2023)
Article
Education & Educational Research
Samia Valeria Ozorio Dutra, Vanessa Chee, John M. Clochesy
Summary: This study proposes an adapted model for language adaptation, using a participatory and iterative process framework. The model follows five dimensions for cross-cultural equivalence and involves expert consultation and online focus groups for consensus. The adapted process utilizes standardized documentation and expert judgment. The study highlights the innovation of applying cultural adaptation concepts to an online learning platform through committee and codebook development strategies.
EDUCATION SCIENCES
(2023)
Article
Biology
Ji Youn Yoo, Daniel Mcskimming, Kalavathy Rajan, Anujit Sarkar, Nicole Labbe, Maureen Groer, Usha Menon
Summary: This pilot study explored the potential association between occupational factors, changes in gut microbiota, and adverse health outcomes in firefighters. The results showed that firefighters had lower intestinal bacterial diversity and a higher presence of pathogenic bacteria. Unique gut bacterial taxa were also observed in firefighters with high PTSD scores. These findings suggest occupational factors and changes in gut microbiota may impact firefighters' health.
Meeting Abstract
Obstetrics & Gynecology
Ronee Wilson, Adriana Campos, Shaheda Urmi, Ji Youn Yoo, Adeola M. Awomolo, Adetola Louis-Jacques
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kelley Baumgartel, Angeline Saint Fleur, Stephanie Prescott, Dany Fanfan, Amanda Elliott, Ji Youn Yoo, Rebecca Koerner, Monalisa Harringon, Samia Ozorio Dutra, Allyson Duffy, Ming Ji, Maureen W. Groer
Summary: Hispanic pregnant women born in the USA have lower income, higher unemployment rate, and higher marriage rate compared to those not born in the USA. Foreign-born Hispanic women report lower social support, less stress, and depression compared to those born in the USA.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2023)
Meeting Abstract
Obstetrics & Gynecology
Anujit Sarkar, Ji Youn Yoo, Jean Lim, Samia Dutra, Larry Dishaw, Bradley Kane, Maureen Groer Edith Groer, Elizabeth Miller
REPRODUCTIVE SCIENCES
(2021)