Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Development by Differentially Compromising the Autophagic Response

Autophagy in liver diseases: Time for translation?

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The severity of rat liver injury by fructose and high fat depends on the degree of respiratory dysfunction and oxidative stress induced in mitochondria

(2019) Claudia Isabel García-Berumen et al.   Lipids in Health and Disease

20-Week follow-up of hepatic steatosis installation and liver mitochondrial structure and activity and their interrelation in rats fed a high-fat–high-fructose diet

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Mitochondrial adaptation in steatotic mice

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Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction

(2018) Michelle L Boland et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatic mitochondrial defects in a mouse model of NAFLD are associated with increased degradation of oxidative phosphorylation subunits.

(2018) Kwangwon Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Association between body mass index and fatty liver risk: A dose-response analysis

(2018) Rui Fan et al.   Scientific Reports

Estrogen Signals Through Peroxisome Proliferator-Activated Receptor−γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease

(2017) Aurèle Besse-Patin et al.   GASTROENTEROLOGY

Accumulation of autophagosomes confers cytotoxicity

(2017) Robert W. Button et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alteration of Liver Peroxisomal and Mitochondrial Functionality in the NZO Mouse Model of Metabolic Syndrome

(2017) Birgit Knebel et al.   Proteomics Clinical Applications

Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity

(2016) Rainey E. Patterson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

(2016) Timothy Hardy et al.   Annual Review of Pathology-Mechanisms of Disease

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances

(2016) Jennie Ka Ching Lau et al.   JOURNAL OF PATHOLOGY

Peroxisomes compensate hepatic lipid overflow in mice with fatty liver

(2015) Birgit Knebel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Phosphatidylethanolamine Is a Key Regulator of Membrane Fluidity in Eukaryotic Cells

(2015) Rosie Dawaliby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disorders of phospholipid metabolism: an emerging class of mitochondrial disease due to defects in nuclear genes

(2015) Ya-Wen Lu et al.   Frontiers in Genetics

Exercise alters liver mitochondria phospholipidomic profile and mitochondrial activity in non-alcoholic steatohepatitis

(2014) Inês O. Gonçalves et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine

(2013) Bianca M. Arendt et al.   Applied Physiology Nutrition and Metabolism

Dysfunctional lysosomal autophagy leads to peroxisomal oxidative burnout and damage during endotoxin-induced stress

(2013) Radovan Vasko et al.   Autophagy

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

(2013) Jennifer E. Lambert et al.   GASTROENTEROLOGY

High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase

(2013) Takuji Ishimoto et al.   HEPATOLOGY

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease

(2013) Yuka Fukuo et al.   HEPATOLOGY RESEARCH

Time Course of the Development of Nonalcoholic Fatty Liver Disease in the Otsuka Long-Evans Tokushima Fatty Rat

(2013) Yi-Sun Song et al.   Gastroenterology Research and Practice

The Role of Nutrients in the Development, Progression, and Treatment of Nonalcoholic Fatty Liver Disease

(2012) Marialena Mouzaki et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression

(2011) Yoshihiro Inami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

(2011) Anabela P. Rolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells

(2010) M. Elsner et al.   DIABETES

Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men

(2010) H. Sobrecases et al.   DIABETES & METABOLISM

Effect of Dietary Monosodium Glutamate on HFCS-Induced Hepatic Steatosis: Expression Profiles in the Liver and Visceral Fat

(2010) Kate S. Collison et al.   Obesity

Peroxisomes Are Oxidative Organelles

(2009) Vasily D. Antonenkov et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

(2009) Zheng Zheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE