Review
Biochemistry & Molecular Biology
Yoon Kyung Choi, Young-Myeong Kim
Summary: Heme oxygenase and its metabolites have dual roles in neurovascular diseases, potentially causing cytotoxic ferroptosis via iron accumulation, but also exhibiting regenerative potential and neurovascular protective effects through CO-mediated signaling pathway, antioxidant properties of bilirubin, and iron-mediated ferritin synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Libor Vitek
Summary: The liver has evolved defense systems to protect against harmful stimuli, including antioxidant substances and enzymes, anti-inflammatory tools, enzymatic biotransformation systems, and metabolic pathways. Recent research indicates the significant role of the heme catabolic pathway in regulating the pathogenesis of liver and other diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Cesare Mancuso
Summary: Biliverdin is a by-product of heme oxygenase activity and can be transformed into bilirubin by biliverdin reductase. When this enzyme is inhibited, biliverdin accumulates in cells and leads to a clinical syndrome called green jaundice. Biliverdin has been shown to have antioxidant effects and target various signaling pathways, making it potentially beneficial in multiple diseases, including ischemia/reperfusion-related diseases, inflammatory diseases, graft-versus-host disease, viral infections, and cancer.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Tamas Gall, David Petho, Annamaria Nagy, Gyorgy Balla, Jozsef Balla
Summary: The study shows that oxidized hemoglobins, globin-derived peptides, and heme trigger diverse biological responses, including toll-like receptor 4 activation with inflammatory response, reprogramming of cellular metabolism, differentiation, stress, and even death. The damage caused by oxidized hemoglobin and heme to cells and tissues is related to the pathological consequences of hemorrhage and hemolysis in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Mirrin J. Dorresteijn, Douwe Dekker, Jelle Zwaag, Suzanne Heemskerk, Hennie M. J. Roelofs, Paul Smits, Johannes G. van der Hoeven, Frank A. D. T. G. Wagener, Peter Pickkers
Summary: Inflammation-induced free radical release is important in the pathogenesis of several diseases. This study investigated the impact of atazanavir-induced hyperbilirubinemia on antioxidant capacity, inflammation, and vascular dysfunction in human experimental endotoxemia. The results showed that hyperbilirubinemia increased antioxidant capacity, attenuated interleukin-10 release, and prevented vascular hyporesponsiveness during systemic inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Khosrow Kashfi, Kush K. Patel
Summary: This article reviews the history of carbon monoxide, highlighting its toxic effects as well as its roles as an endogenously produced molecule and therapeutic agent. The research into its physiological functions and therapeutic applications are often overshadowed by its reputation as a lethal substance.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Stefan W. Ryter
Summary: The heme oxygenase-1 (HO-1) enzyme and its reaction products have beneficial effects in human diseases, including cardiovascular disease, metabolic conditions, and acute and chronic diseases of the liver, kidney, or lung. Modulating the HO-1 pathway, such as regulating HO-1 expression or using reaction products, has therapeutic potential in inflammatory conditions.
Article
Biochemistry & Molecular Biology
Charifa Awada, Alice Bourgeois, Sarah-Eve Lemay, Yann Grobs, Tetsuro Yokokawa, Sandra Breuils-Bonnet, Sandra Martineau, Vinod Krishna, Francois Potus, Jey Jeyaseelan, Steeve Provencher, Sebastien Bonnet, Olivier Boucherat
Summary: Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling, and the inhibition of the histone methyltransferase G9a/GLP may represent a new therapeutic approach for PAH.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Review
Cell Biology
Hua-Li Qin, Jing-Hui Bao, Jian-Jun Tang, Dan-Yan Xu, Li Shen
Summary: Arterial remodeling is a common pathological process in cardiovascular diseases, and vascular smooth muscle cells play a key role in this process. Mitochondrial dysfunction and oxidative stress contribute to the phenotypic transformation of vascular smooth muscle cells, leading to the onset and progression of arterial remodeling. Improving mitochondrial function may be a new intervention strategy to prevent arterial remodeling and treat related cardiovascular diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Yoon Kyung Choi, Young-Myeong Kim
Summary: The interaction between CO and NO plays a crucial role in maintaining vascular homeostasis and regeneration by improving endothelial function and promoting cell-cell communication, thus sustaining the health of cardiovascular and neurovascular systems.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yixiao Luo, Rafi Ullah, Jinfeng Wang, Yuru Du, Shihao Huang, Li Meng, Yuan Gao, Miao Gong, Ewa Galaj, Xi Yin, Haishui Shi
Summary: The study demonstrated that carbon monoxide (CO) has significant antidepressant and anxiolytic effects, providing protection through activation of HO-1 and exogenous CO administration. This research revealed a novel function of the HO-1/CO system, offering a promising therapeutic target for the treatment of depression and anxiety.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lucia Longhitano, Giuseppe Broggi, Sebastiano Giallongo, Maria Failla, Lidia Puzzo, Teresio Avitabile, Daniele Tibullo, Alfio Distefano, Valeria Pittala, Michele Reibaldi, Guido Nicola Zanghi, Antonio Longo, Andrea Russo, Rosario Caltabiano, Giovanni Li Volti, Nicolo Musso
Summary: The study revealed the important role of HO-1 in regulating uveal melanoma progression, with an increase of HO-1 promoting cellular proliferation and wound healing ability of tumor cells, suggesting HO-1 protein expression may serve as a potential prognostic and therapeutic factor in UM patients.
Article
Critical Care Medicine
Geraldine Vitry, Roxane Paulin, Yann Grobs, Marie-Claude Lampron, Tsukasa Shimauchi, Sarah-Eve Lemay, Eve Tremblay, Karima Habbout, Charifa Awada, Alice Bourgeois, Valerie Nadeau, Renee Paradis, Sandra Breuils-Bonnet, Florence Roux-Dalvai, Mark Orcholski, Francois Potus, Steeve Provencher, Olivier Boucherat, Sebastien Bonnet
Summary: The study identified an increased expression of detoxifying DNA enzyme NUDT1 in patients with pulmonary arterial hypertension (PAH) and animal models, with its inhibition leading to improvements in DNA damage, cell death, and vascular remodeling, as well as hemodynamics and cardiac function in animal models of PAH. These findings suggest that NUDT1 inhibitors may represent a new therapeutic option for PAH patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tao Wu, Xiaotian Liu, Ting Wang, Li Tian, Hao Qiu, Feng Ge, Jing Zhu, Liang Shi, Ailiang Jiang, Hanshou Yu, Ang Ren
Summary: This study found that the HO/CO system can respond to heat stress and regulate Ganoderma lucidum's ganoderic acid biosynthesis and cell wall integrity by regulating the Slt-MAPK phosphorylation level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wangsheng Jiang, Wenfeng Ruan, Zhengqiang Wang
Summary: This study found that Dendrobium officinale polysaccharide (DOP) can alleviate vascular calcification in patients with chronic kidney disease (CKD) by suppressing inflammation and apoptosis through the activation of heme oxygenase-1 (HMOX-1). These results provide a promising treatment approach for vascular calcification in CKD.
Article
Biochemistry & Molecular Biology
Kelly J. Peyton, Xiao-ming Liu, Ahmad R. Shebib, Fruzsina K. Johnson, Robert A. Johnson, William Durante
Review
Nutrition & Dietetics
William Durante
Review
Biochemistry & Molecular Biology
William Durante, Ghazaleh Behnammanesh, Kelly J. Peyton
Summary: SGLT2 inhibitors improve cardiovascular outcomes in patients with diabetes through various mechanisms such as increasing nitric oxide bioavailability, regulating endothelial cell function, and exerting antioxidant and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
William Durante
Summary: COVID-19 patients have a deficiency of circulating arginine, which can lead to immune and vascular cell dysfunction, promoting the development of inflammation and vascular disease.
Review
Biochemistry & Molecular Biology
William Durante
Summary: The COVID-19 pandemic has resulted in the deaths of nearly 7 million people worldwide. Clinical data has revealed a deficiency of circulating glutamine in COVID-19 patients, which is associated with disease severity. The disturbed glutamine metabolism may lead to immune and endothelial cell dysfunction, causing severe infection, inflammation, oxidative stress, vasospasm, and coagulopathy, ultimately resulting in vascular occlusion, multi-organ failure, and death. Strategies that restore glutamine levels, its metabolites, and/or downstream effectors, in combination with antiviral drugs, offer a promising therapeutic approach to restore immune and endothelial cell function and prevent occlusive vascular disease in COVID-19 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kelly J. Peyton, Ghazaleh Behnammanesh, Giovanna L. Durante, William Durante
Summary: Research shows that canagliflozin can act as a novel inducer of HO-1 in human ECs. While HO-1 contributes to the anti-inflammatory action, it does not affect the anti-proliferative and antimigratory effects of the drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)