Article
Infectious Diseases
Lu Gao, Xiangdong Sun, Honglin Yang, Quangang Xu, Juan Li, Jingli Kang, Ping Liu, Yi Zhang, Youming Wang, Baoxu Huang
Summary: The study conducted a preliminary analysis of African swine fever outbreaks in China, finding significantly higher outbreak rates in small farms compared to medium and large farms. Swill feeding and mechanical dissemination were identified as major contributing factors. The response speed has been gradually increasing. Recommendations include improving biosecurity levels and enhancing supervision in breeding, transportation, and slaughter practices.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Virology
Elizabeth Vuono, Elizabeth Ramirez-Medina, Sarah Pruitt, Ayushi Rai, Ediane Silva, Nallely Espinoza, James Zhu, Lauro Velazquez-Salinas, Douglas P. Gladue, Manuel V. Borca
Summary: Deletion of the I8L gene from ASFV-G does not significantly impact virus replication in vitro or in vivo, and does not alter the disease outcome in swine. The study found that the recombinant virus lacking the I8L gene replicated similarly to the parent virus in swine macrophage cultures and displayed similar replication kinetics and disease presentation in swine when inoculated intramuscularly.
Article
Virology
Elizabeth Ramirez-Medina, Ayushi Rai, Nallely Espinoza, Alyssa Valladares, Ediane Silva, Lauro Velazquez-Salinas, Manuel V. Borca, Douglas P. Gladue
Summary: African swine fever (ASF) is a highly contagious disease affecting wild and domestic swine. Deletion of the ASFV gene H240R from the genome of the virus led to a decrease in virulence when tested on domestic swine. The recombinant virus ASFV-G-Delta H240R showed reduced fatality rates and virus titers compared to the virulent parental virus ASFV-G.
Article
Immunology
Priscilla Y. L. Tng, Laila Al-Adwani, Egle Pauletto, Joshua Y. K. Hui, Christopher L. Netherton
Summary: African swine fever (ASF) is a lethal disease in pigs with significant socio-economic implications worldwide. This study developed luciferase-linked antibody capture assays (LACAs) to profile antigen-specific antibody responses against ASFV capsid proteins. The study identified antibodies associated with recovery from disease and reduced clinical signs in immunized animals.
Article
Agriculture, Multidisciplinary
Cheng-gang Jiang, Ying Sun, Zhang Fan, Xin Ai, Xiao-ning Feng, Wei Hu, Xian-feng Zhang, Dong-ming Zhao, Zhi-gao Bu, Xi-jun He
Summary: The study evaluated the virucidal activity of six common disinfectants against ASFV and found that these disinfectants can completely inactivate the virus at specific concentrations and exposure times, but their effectiveness is reduced in the presence of organic material contamination. In order to enhance biosecurity, disinfection procedures should include thorough mechanical cleaning followed by application of the disinfectant.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Veterinary Sciences
Satoshi Ito, Jaime Bosch, Marta Martinez-Aviles, Jose Manuel Sanchez-Vizcaino
Summary: The study highlights the distribution of lower virulent African swine fever virus in China and the potential risk of the virus spreading from China to other regions of the world.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Immunology
Zilong Qiu, Zhaoyao Li, Quanhui Yan, Yuwan Li, Wenjie Xiong, Keke Wu, Xiaowen Li, Shuangqi Fan, Mingqiu Zhao, Hongxing Ding, Jinding Chen
Summary: African swine fever, caused by the African swine fever virus, is a highly contagious global disease that spread rapidly since its introduction to Georgia in 2007. With no vaccine currently available, prevention and control rely on early detection and strict biosecurity measures.
Article
Virology
M. Borca, A. Rai, E. Ramirez-Medina, E. Silva, L. Velazquez-Salinas, E. Vuono, S. Pruitt, N. Espinoza, D. P. Gladue
Summary: African swine fever virus (ASFV) is causing devastating losses to the swine industry, but there is currently no commercial vaccine available. A newly developed ASF vaccine can replicate efficiently in stable porcine cell cultures while maintaining protective efficacy.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Edward Spinard, Ayushi Rai, Jehadi Osei-Bonsu, Vivian O'Donnell, Patrick T. Ababio, Daniel Tawiah-Yingar, Daniel Arthur, Daniel Baah, Elizabeth Ramirez-Medina, Nallely Espinoza, Alyssa Valladares, Bonto Faburay, Aruna Ambagala, Theophlius Odoom, Manuel V. Borca, Douglas P. Gladue
Summary: African swine fever (ASF) has been causing outbreaks in Africa for over a century and since 1957, sporadic outbreaks have occurred outside Africa. The current ASF pandemic, originating from a 2007 outbreak in Georgia, has been particularly devastating. This study collected ASF isolates from samples in Ghana and found that the circulating strains in 2022 were derivatives of the p72 Genotype II pandemic strain, demonstrating the emergence of Genotype II ASFV in Ghana for the first time.
Article
Veterinary Sciences
Natalia Kholod, Andrey Koltsov, Galina Koltsova
Summary: This study used transcriptome analysis to compare the differences in gene expression between homologous and heterologous strains of African swine fever (ASF) infection. The results revealed changes in gene expression related to immune response, inflammatory response, and endoplasmic reticulum stress in cells infected with heterologous strains. These findings may have implications for vaccine development and testing.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Microbiology
Hongliang Zhang, Saisai Zhao, Haojie Zhang, Zhihua Qin, Hu Shan, Xiulei Cai
Summary: African swine fever (ASF) is a fatal infectious disease caused by the ASF virus (ASFV). It is classified as a legally notifiable disease that must be reported to the World Organization for Animal Health. The global pig industry has suffered significant economic losses due to ASF, and controlling and eradicating the disease is crucial. Vaccination is the optimal strategy, but an effective ASF vaccine with high immunoprotective potential is still needed.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Virology
Jiakai Zhao, Jiahong Zhu, Ying Wang, Mengting Yang, Qiang Zhang, Chong Zhang, Yuchen Nan, En-Min Zhou, Yani Sun, Qin Zhao
Summary: A simple nanobody-based competitive ELISA method has been developed in this study to detect the presence of antibodies against ASFV in pig sera. The method is characterized by its low cost, easy production, and 100% agreement with a commercial ELISA kit.
Article
Virology
Daniel L. Rock
Summary: African swine fever is an acute viral hemorrhagic disease with mortality rates approaching 100%, which has spread to multiple regions in Europe and Asia. The epidemic poses a serious threat to the global pork industry, necessitating immediate and effective measures for disease control.
Article
Virology
Edward Spinard, Mark Dinhobl, Nicolas Tesler, Hillary Birtley, Anthony V. Signore, Aruna Ambagala, Charles Masembe, Manuel V. Borca, Douglas P. Gladue
Summary: The African swine fever virus (ASFV) is causing a highly lethal disease in domestic swine and wild boar worldwide. Understanding the molecular basis and usefulness of ASFV genotyping is important for the epidemiology, transmission, evolution, control, and prevention of the virus. By reanalyzing genomic data, it is proposed to reduce the current 25 genotypes based on the p72 sequence to only six genotypes using Arabic numerals for classification.
Article
Immunology
Maksym Bezymennyi, Oleksandr Tarasov, Ganna V. Kyivska, Nataliia A. Mezhenska, Svitlana Mandyhra, Ganna Kovalenko, Mykola Sushko, Nataliia Hudz, Serhii V. Skorokhod, Roman Datsenko, Larysa Muzykina, Elaina Milton, Maryna A. Sapachova, Serhii Nychyk, Ihor Halka, Maciej Frant, Falk Huettmann, Devin M. Drown, Anton Gerilovych, Andrii A. Mezhenskyi, Eric Bortz, Christian E. Lange
Summary: African swine fever (ASF) is a viral disease that originated in Africa and has spread to Europe and Asia, causing high mortality in domestic pig populations. In Ukraine, ASF outbreaks have been reported since 2012, with the highest numbers in 2017 and 2018. The spread of ASF in Ukraine shows a directional pattern from the eastern and northern borders towards the western and southern regions, and wild boars may have played a role in the early spread. However, human activity is now the main driver of spread, and effective mitigation strategies have led to a decline in outbreaks since 2019.
