期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.568366
关键词
circular RNA; circRNA; exosome; exosomal circRNA; cancer progression; biomarker
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [20J11303, 19H03430, 20J20625]
- Translational Research program
- Strategic promotion for practical application of innovative medical technology, TR-SPRINT, from the Japan Agency for Medical Research and Development, AMED
- JST CREST [JPMJCR19H5]
- Practical Research for Innovative Cancer Control Program from AMED [JP20ck0106557]
- Grants-in-Aid for Scientific Research [20J11303, 19H03430, 20J20625] Funding Source: KAKEN
Circular RNA (circRNA) is a type of non-coding RNA that forms a covalently closed continuous loop. The expression pattern of circRNA varies among cell types and tissues, and many circRNAs are aberrantly expressed in various cancers. Aberrantly expressed circRNAs have been shown to play crucial roles in carcinogenesis, functioning as microRNA sponges or new templates for protein translation. Recent research has shown that circRNAs are enriched in exosomes. Exosomes are secretory vesicles that mediate intercellular communication through the delivery of cargo, including proteins, lipids, DNA, and RNA. Exosome-mediated crosstalk between cancer cells and the tumor microenvironment promotes the epithelial-mesenchymal transition, angiogenesis, and immune escape, and thus may contribute to cancer invasion and metastasis. In this review, we discuss the biological functions of exosomal circRNAs and their significance in cancer progression. Additionally, we discuss the potential clinical applications of exosomal circRNAs as biomarkers and in cancer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据