Article
Neurosciences
Inmaculada Crespo, Jaime Pignatelli, Veena Kinare, Hector R. Mendez-Gomez, Miriam Esgleas, Maria Jose Roman, Josep M. Canals, Shubha Tole, Carlos Vicario
Summary: This study investigates the impact of misexpression of the Tbr1 transcription factor on mouse neural progenitor cells. The results suggest that Tbr1 misexpression delays or disrupts neuronal migration, specification, and dendrite development, potentially leading to brain malformations.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Yuki Yamazaki, Maho Moizumi, Jun Nagai, Yoshiki Hatashita, Tianhong Cai, Papachan Kolattukudy, Takafumi Inoue, Yoshio Goshima, Toshio Ohshima
Summary: This study demonstrated the importance of Cdk5-mediated phosphorylation of CRMP2 in neuronal migration in the developing cerebral cortex, with redundant functions of CRMP1 and CRMP4. Experimental results showed that these three proteins play crucial roles in proper neuronal migration.
Article
Neurosciences
Ji-Wei Liu, Han Li, Yang Zhang
Summary: This study investigates the role of the neuronal gene Npas3 in cortical development in mice. The knockdown of Npas3 impairs neuronal radial migration and alters cell fate in deep cortical layers. Additionally, the downregulation of Npas3 maintains the stemness of radial glial cells and increases the proliferation rate of neural progenitor cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Seonhye Cheon, Allison M. Culver, Anna M. Bagnell, Foster D. Ritchie, Janay M. Vacharasin, Mikayla M. McCord, Carin M. Papendorp, Evelyn Chukwurah, Austin J. Smith, Mara H. Cowen, Trevor A. Moreland, Pankaj S. Ghate, Shannon W. Davis, Judy S. Liu, Sofia B. Lizarraga
Summary: ASH1L plays a role in regulating neuronal morphogenesis by counteracting the catalytic activity of PRC2. Depletion of ASH1L leads to decreased neurite outgrowth and decreased expression of the gene TrkB, which is linked to neuronal morphogenesis. The neuronal morphogenesis defect can be overcome by inhibiting PRC2 activity.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Madhura S. S. Rao, Hiromi Mizuno, Takuji Iwasato, Hidenobu Mizuno
Summary: In this study, the roles of Ras GTPase-activating proteins (RasGAPs) in cortical circuit formation were explored using the tactile somatosensory pathway in rodents. The results demonstrate the essential roles of RasGAPs in dendritic pattern formation and presynaptic bouton number in the somatosensory cortex.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Ziheng Zhou, Yueyang Pan, Si Zhou, Shuguang Wang, Dengwei Zhang, Ye Cao, Xiaosen Jiang, Jie Li, Linnan Zhu, Lijian Zhao, Shen Gu, Ge Lin, Zirui Dong, Hai-Xi Sun
Summary: This study investigates the mechanisms of corticogenesis by analyzing single-cell RNA sequencing data from mouse and human fetal cortexes. The study identifies a specific population of cells, called D-T-U, which undergoes direct neuronal transition from deep-layer neurons to upper-layer neurons during fetal cortical development in mice. These findings may shed light on the differences in cortical development between humans and mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Beatriz Rebollo, Bartosz Telenczuk, Alvaro Navarro-Guzman, Alain Destexhe, Maria V. Sanchez-Vives
Summary: Neurons synaptically interacting in a conductive medium generate extracellular endogenous electric fields (EFs) that reciprocally affect membrane potential. Exogenous EFs modulate neuronal activity, and their clinical applications are being profusely explored. The study suggests that slow oscillations in the cerebral cortex network generate EFs that propagate independently of synaptic transmission and contribute to synchronization of neighboring cortical columns.
Review
Neurosciences
Peter William Hogg, Patrick Coleman, Tristan Dellazizzo Toth, Kurt Haas
Summary: Recent technological advancements have enabled direct studies of neuronal morphogenesis, allowing for detailed quantification of structural changes over time. Dynamic morphometrics methods have provided new insights into growth patterns, molecular mechanisms, and the influence of external factors on neural development, particularly in vertebrate systems.
TRENDS IN NEUROSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yael Macarena Cuasolo, Sebastian Dupraz, Nicolas Unsain, Mariano Bisbal, Gonzalo Quassollo, Mauricio R. Galiano, Diego Grassi, Santiago Quiroga, Lucas Javier Sosa
Summary: The development of mammalian neocortex requires migration of neurons from the ventricular zone to the cortical plate. This migration is regulated by small GTPase Rab21, which influences cell migration by controlling the trafficking of endocytic vesicles containing adhesion molecules. In this study, it is demonstrated that Rab21 plays a critical role in cortical neuronal differentiation and migration by regulating amyloid precursor protein levels on the neuronal cell surface. These findings improve our understanding of cerebral cortex development and cortical development disorders associated with Rab21 signaling effectors malfunction.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Neurosciences
Yuki Bando, Masaru Ishibashi, Satoru Yamagishi, Atsuo Fukuda, Kohji Sato
Summary: This review summarizes the functions of ion channels and transporters in neocortical development and discusses the links between channelopathies and neocortical development. Furthermore, it introduces emerging optical techniques for studying neocortical development and the pathophysiology of channelopathies.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biophysics
Liam S. Turk, Michael J. Currie, Renwick C. J. Dobson, Davide Comoletti
Summary: Neuronal development and function rely on the glycoprotein Reelin, which is processed into fragments with distinct roles. The C-terminal fragment RR8 is important for Reelin signaling and receptor specificity, showing both similarities and differences with other RR domains. Structural studies and protein engineering have provided insights into the interactions between Reelin and its receptors.
BIOPHYSICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Owen H. Funk, Yaman Qalieh, Daniel Z. Doyle, Mandy M. Lam, Kenneth Y. Kwan
Summary: The histone variant H3.3 plays crucial roles in neuronal development. Newly born cortical excitatory neurons accumulate H3.3 immediately postmitosis, and deletion of H3.3-encoding genes disrupts the establishment of the neuronal transcriptome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Lucia Melloni, Liad Mudrik, Michael Pitts, Katarina Bendtz, Oscar Ferrante, Urszula Gorska, Rony Hirschhorn, Aya Khalaf, Csaba Kozma, Alex Lepauvre, Ling Liu, David Mazumder, David Richter, Hao J. Zhou, Hal Blumenfeld, Melanie Boly, David P. Chalmers, Sasha Devore, Francis Fallon, Floris de Lange, Ole I. Jensen, Gabriel Kreiman, Huan Luo, Theofanis Panagiotaropoulos, Stanislas Dehaene, Christof Koch, Giulio Tononi
Summary: The relationship between conscious experience and brain activity has been a subject of interest for scientists and philosophers for centuries. In order to advance the research on consciousness, an adversarial collaboration was established between proponents of two major theories in the field. Two experiments were designed to test the contrasting predictions of these theories and provide decisive evidence in favor or against them. The study will involve six independent laboratories and use three complementary methods to obtain data.
Article
Cell Biology
Manuela D. Mitsogiannis, Anna Pancho, Tania Aerts, Sonja M. Sachse, Ria Vanlaer, Lut Noterdaeme, Dietmar Schmucker, Eve Seuntjens
Summary: DSCAMs are involved in various neurodevelopmental processes, and their malfunction can lead to disorders such as Fragile X syndrome, intellectual disability, autism, and bipolar disorder. While Dscam and Dscaml1 knockout did not significantly affect developmental events in mice, gain of function experiments showed negative impacts on neural migration processes important for cortical development. This highlights the importance of genes encoding adhesive cues in neuronal migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Polymer Science
Li Yao, Kimmy Tran, Diana Nguyen
Summary: Glioma cells produce an increased amount of collagen, which affects the invasion ability of tumor cells. This study tested the migration of glioma cells, fetal astrocytes, and adult astrocytes in a 3D collagen matrix with different collagen concentrations, and found higher motility in a low concentration of collagen hydrogel. It was also discovered that glioma cells responded to direct current electric field stimulation and migrated to the anodal pole.
Article
Neurosciences
Matthew L. Kraushar, Barbara Viljetic, H. R. Sagara Wijeratne, Kevin Thompson, Xinfu Jiao, Jack W. Pike, Vera Medvedeva, Matthias Groszer, Megerditch Kiledjian, Ronald P. Hart, Mladen-Roko Rasin
JOURNAL OF NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
S. P. Zadorsky, Y. V. Sopova, D. Y. Andreichuk, V. A. Startsev, V. P. Medvedeva, S. G. Inge-Vechtomov
Article
Neurosciences
Franziska Richter, Bernhard H. Meurers, Chunni Zhu, Vera P. Medvedeva, Marie-Francoise Chesselet
JOURNAL OF COMPARATIVE NEUROLOGY
(2009)
Article
Neurosciences
Miriam A. Hickey, Chunni Zhu, Vera Medvedeva, Nicholas R. Franich, Michael S. Levine, Marie-Francoise Chesselet
MOLECULAR AND CELLULAR NEUROSCIENCE
(2012)
Article
Neurosciences
Miriam A. Hickey, Chunni Zhu, Vera Medvedeva, Renata P. Lerner, Stefano Patassini, Nicholas R. Franich, Panchanan Maiti, Sally A. Frautschy, Scott Zeitlin, Michael S. Levine, Marie-Francoise Chesselet
MOLECULAR NEURODEGENERATION
(2012)
Article
Neurosciences
Franziska Richter, Fuying Gao, Vera Medvedeva, Patrick Lee, Nicholas Bove, Sheila M. Fleming, Magali Michaud, Vincent Lemesre, Stefano Patassini, Krystal De La Rosa, Caitlin K. Mulligan, Pedrom C. Sioshansi, Chunni Zhu, Giovanni Coppola, Thierry Bordet, Rebecca M. Pruss, Marie-Francoise Chesselet
NEUROBIOLOGY OF DISEASE
(2014)
Article
Biochemistry & Molecular Biology
Vera P. Medvedeva, Michael A. Rieger, Beate Vieth, Cedric Mombereau, Christoph Ziegenhain, Tanay Ghosh, Arnaud Cressant, Wolfgang Enard, Sylvie Granon, Joseph D. Dougherty, Matthias Groszer
HUMAN MOLECULAR GENETICS
(2019)
Article
Biochemistry & Molecular Biology
Galya Monderer-Rothkoff, Nitzan Tal, Marina Risman, Odem Shani, Malka Nissim-Rafinia, Laura Malki-Feldman, Vera Medvedeva, Matthias Groszer, Eran Meshorer, Sagiv Shifman
Summary: Mutations in AUTS2 gene are associated with autism, intellectual disability, and microcephaly. Transition from long to short isoform of AUTS2 is crucial for regulating transcription and neuronal differentiation.
MOLECULAR PSYCHIATRY
(2021)