Article
Pharmacology & Pharmacy
Silong Chen, Chengshou Zhang, Lifang Shen, Jianghua Hu, Xiangjun Chen, Yibo Yu
Summary: This review summarizes the research on the role of non-coding RNA (ncRNA) in cataracts. Recent studies have found that ncRNA plays a significant role in cataract formation by regulating cellular activities. Due to its importance in cataracts, further research on novel regulatory mechanisms is urgently needed, and the development of alternative therapies for cataract treatment seems promising.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Seung Wan Son, Mun Gyu Song, Ba Da Yun, Jong Kook Park
Summary: Therapeutic resistance is a major obstacle in cancer treatment, regulated by signaling pathways and noncoding RNAs.
Review
Cell Biology
Alessio Grimaldi, Giuseppe Pietropaolo, Helena Stabile, Andrea Kosta, Cristina Capuano, Angela Gismondi, Angela Santoni, Giuseppe Sciume, Cinzia Fionda
Summary: Innate lymphoid cells (ILCs) are innate lymphocytes that play essential roles in host protection and pathological conditions. Besides lineage-defining transcription factors, ncRNAs also play crucial roles in controlling ILC development and function, mainly by regulating gene expression to tune distinct functional outputs in ILCs.
Review
Neurosciences
Ying Bai, Hui Ren, Liang Bian, You Zhou, Xinping Wang, Zhongli Xiong, Ziqi Liu, Bing Han, Honghong Yao
Summary: Non-coding RNAs, such as microRNAs, long ncRNAs, and circular RNAs, are highly expressed in the brain and play critical roles in regulating the physiological and pathological processes of central nervous system diseases. Elucidating the mechanisms of ncRNAs in regulating glial function could lead to the identification of novel therapeutic targets for CNS diseases.
NEUROSCIENCE BULLETIN
(2023)
Article
Oncology
Zhengjun Lin, Xubin Xie, Shiyao Lu, Tang Liu
Summary: Osteosarcoma is the most frequent bone malignancy in children and adolescents, with the development of multi-drug resistance posing a major obstacle in improving chemotherapy efficacy. Research has shown that noncoding RNAs play significant roles in osteosarcoma progression and chemosensitivity, highlighting their potential as biomarkers and therapeutic targets for improving patient prognosis.
Review
Biochemistry & Molecular Biology
Sumio Hayakawa, Tomokazu Ohishi, Yumiko Oishi, Mamoru Isemura, Noriyuki Miyoshi
Summary: Polyphenols have anticancer effects by acting as antioxidants and modulating cell signaling pathways, with ncRNA modulation enhancing these effects.
Review
Biochemistry & Molecular Biology
Ziwei Li, Peng Tian, Tengbo Huang, Jianzi Huang
Summary: Macronutrient elements play crucial roles in plant growth and development, with deficient or excessive supply triggering various plant responses; noncoding RNAs, including miRNAs and lncRNAs, may serve as key regulators in plant responses to macronutrient stress; high-throughput sequencing has provided valuable data for the identification and characterization of nutrient-responsive ncRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Amir Safi, Mohammadreza Saberiyan, Mohammad-Javad Sanaei, Samaneh Adelian, Fateme Davarani Asl, Mahsa Zeinaly, Mahdi Shamsi, Reza Ahmadi
Summary: Metabolic reprogramming is a well-known feature of cancer, and noncoding RNAs (ncRNAs) have been found to play a role in this process. This review focuses on the metabolism of glucose, lipids, and amino acids in cancer cells, and highlights the therapeutic potential of targeting ncRNAs in cancer treatment.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Review
Pharmacology & Pharmacy
Hyunjong Kim, Jaesub Kim, Juhee Ryu
Summary: Retinopathy of prematurity (ROP) is a vascular disease that has become a primary cause of blindness in children worldwide. Although current therapies such as laser therapy and pharmacologic agents are commonly used to treat ROP, the search for novel therapeutic targets with less destructive properties is necessary. Noncoding RNA therapy has shown potential as next-generation therapy for treating ROP by regulating various noncoding RNAs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Ghaidaa Raheem Lateef Al-Awsi, Methaq Hadi Lafta, Hamzah Hashim Kzar, Gulnoza Samieva, Fahad Alsaikhan, Irshad Ahmad, Marwan Mahmood Saleh, Abdelgadir Alamin Altoum, Surendar Aravindhan, Yasser Fakri Mustafa, Reza Mahmoudi, Asgar Mohammadi
Summary: This article reviews the relationship between non-coding RNAs and the PCSK9 pathway, revealing their roles in the pathogenesis of inflammatory atherosclerosis and introducing potential therapeutic interventions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Critical Care Medicine
Tao Zhang, Yu-Hang Yang, Yong-Ping Liu, Tie-Ning Zhang, Ni Yang
Summary: This review suggests that ncRNAs could serve as potential biomarkers and therapeutic targets for sepsis and SAOD. Further research is needed to validate these findings and evaluate their clinical utility.
Review
Pharmacology & Pharmacy
Yulai Zeng, Shuyu Hu, Yi Luo, Kang He
Summary: Hepatocellular carcinoma (HCC) is a common cancer with unsatisfactory early diagnosis and treatment. Exosomes, containing various components, play a crucial role in the development and prognosis of HCC. Biomarkers in exosomes show potential for novel diagnostic and prognostic tools for HCC.
Review
Medicine, Research & Experimental
Bin Zhang, Liming Yang, Yang He, Dali Han, Peng Qi, Panfeng Shang
Summary: Bladder cancer is the most common urothelial cancer, and metabolic reprogramming is gaining attention in its development. Recent studies have shown a strong correlation between noncoding RNAs and metabolic reprogramming in bladder cancer. Noncoding RNAs can directly or indirectly regulate the expression and function of metabolic enzymes in bladder cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Genetics & Heredity
Zifan Yue, Pei Mou, Sainan Chen, Fei Tong, Ruili Wei
Summary: A study investigated the lncRNA/circRNA-miRNA-mRNA network in Graves' ophthalmopathy (GO) patients, revealing significant differences in RNA expression levels compared to control patients. Through high-throughput sequencing and qPCR validation, the study identified key genes and constructed ceRNA networks. This innovative study identified two important ceRNA pathways that may impact autoimmune response and inflammation in GO patients.
FRONTIERS IN GENETICS
(2021)
Review
Immunology
Shufan Liang, Jiechao Ma, Hanlin Gong, Jun Shao, Jingwei Li, Yuejuan Zhan, Zhoufeng Wang, Chengdi Wang, Weimin Li
Summary: This article reviews the role of noncoding RNAs (ncRNAs) in Mycobacterium tuberculosis infection, highlighting their impact through immune response modulation, and their potential as biomarkers for tuberculosis diagnosis, drug resistance identification, treatment evaluation, and adverse drug reaction prediction.
FRONTIERS IN IMMUNOLOGY
(2022)
