Article
Nanoscience & Nanotechnology
Dan Zhao, Xiaoyu Huang, Yanan Tian, Jianhua Zou, Fu Wang, Xiaoyuan Chen
Summary: Ferroptosis is a new type of programmed cell death that plays a crucial role in tumor inhibition. This study introduces a facile fluorescence imaging-incorporated transcriptome strategy to visualize and explore the mechanism of GSH depletion-enhanced ferroptosis. The results demonstrate that TfRA-AuNCs, a multifunctional nanoplatform, can enhance the ferroptosis effect in 4T1 cells and regulate the expression change of ferroptosis-related genes. In vivo results confirm the tumor inhibition effect and long-term biocompatibility after TfRA-AuNC treatment. This study provides new insights into the mechanistic study of nanoagent-induced ferroptosis in tumor treatment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Zheng Li, Jianhua Zou, Xiaoyuan Chen
Summary: Subcellular targeted cancer therapy has emerged as a potent anticancer treatment, providing great opportunities for clinical application. This review summarizes two targeting strategies for four main subcellular organelles, including molecule- and nanomaterial-based targeted delivery or therapeutic strategies. Various treatment strategies such as phototherapy, chemotherapy, radiotherapy, immunotherapy, and combination therapy are discussed in detail. The construction of specific materials based on the properties and mechanisms of organelles allows for the elimination of tumors by inducing dysfunction or destroying specific structures. The challenges faced by organelle-targeting cancer therapies are also summarized. A paradigm for organelle-targeting therapy with enhanced therapeutic efficacy is envisioned.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Chenchen Zhao, Yuanwei Pan, Guocan Yu, Xing-Zhong Zhao, Xiaoyuan Chen, Lang Rao
Summary: The high stability and binding specificity of antibodies make them widely applicable in various diseases. However, there are limitations to traditional antibody-based therapeutics. Recent advances in cell membrane nanotechnology have led to the development of vesicular-antibody-based therapeutics, which offer new possibilities for disease treatment.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Physical
Xiaoming Hu, Fengwei Sun, Caijun Zhu, Zhen Yang, Wei Huang
Summary: Optical imaging has significant implications in early disease diagnosis, timely treatment, and medical and biological research. The emerging NIR-II window optical imaging technology provides non-invasive, non-ionizing radiation, and real-time dynamic imaging capabilities, with improved tissue penetration and detection sensitivity, enabling accurate diagnosis of major diseases. This review highlights the use of organic semiconducting nanomaterials (OSNs) for NIR-II fluorescence imaging, emphasizing their advantages in visualizing various diseases and outlining their potential for clinical translation.
Review
Nanoscience & Nanotechnology
Lisi Xie, Jie Li, Leyu Wang, Yunlu Dai
Summary: The tumor microenvironment (TME) is a complex environment characterized by low pH values, high redox status, and hypoxia, which plays a significant role in the genesis, development, and metastasis of tumors. Immunosuppressive cells infiltrate in the TME, leading to the failure of immunotherapy. Therefore, the development of TME-responsive nanoplatforms is essential for enhancing cancer therapeutics. Metal-phenolic networks (MPNs)-based nanosystems, self-assembled via coordination of phenolic materials and metal ions, have emerged as excellent TME theranostic platforms.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mengyao Zhao, Hongjun Zhuang, Benhao Li, Meiwan Chen, Xiaoyuan Chen
Summary: A supramolecular coordination-induced nanoparticle cross-linking strategy is developed for enhanced photodynamic therapy by utilizing a complementary functioning tumor microenvironment. The coordinated interaction between manganese oxide and polyhydroxy photosensitizer hypericin improves the energy transfer efficiency and enhances the intracellular accumulation of both upconversion nanoparticles and hypericin. This strategy realizes the function amplification of each component after responsive transformation and offers a new avenue for enhanced cancer therapy.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Yilin Song, Qing You, Xiaoyuan Chen
Summary: Inflammatory disease refers to a class of diseases in which chronic inflammation is the major manifestation of pathogenesis. Traditional therapies based on anti-inflammatory and immunosuppressive drugs only provide short-term remission. The emergence of nanodrugs holds great potential for the treatment of inflammatory diseases by addressing potential causes and preventing recurrences. Transition metal-based smart nanosystems (TMSNs) possess unique electronic structures and therapeutic advantages, making them promising for the treatment of various inflammatory diseases.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Benhao Li, Mengyao Zhao, Weiping Lai, Xuanbo Zhang, Bowei Yang, Xiaoyuan Chen, Qianqian Ni
Summary: This study introduces a pH activatable near-infrared (NIR-II) lipid nanoparticle (LNP) system for enhancing mRNA delivery efficiency. The NIR-II dye conjugated lipid in the LNPs is protonated in the acidic endosomal microenvironment and absorbs NIR-II light upon laser irradiation, leading to light-to-heat conversion. The generated heat triggers rapid escape of the LNPs from the endosome, resulting in a 3-fold enhancement of mRNA translation capacity compared to the control group without NIR-II light. The validity of this strategy is further confirmed by the positive correlation between bioluminescence intensity induced by delivered luciferase encoding mRNA and incremental radiation dose in the mouse liver region.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Fantian Zeng, Sureya Nijiati, Longguang Tang, Jinmin Ye, Zijian Zhou, Xiaoyuan Chen
Summary: Understanding the intricate molecular machinery of ferroptosis and leveraging this knowledge can advance disease prevention, diagnosis, treatment, and prognosis. New approaches for in situ detection of key regulators and events provide a comprehensive view of ferroptosis across different scales. Advanced applications integrating ferroptosis detection with cutting-edge technologies show great potential in ferroptosis research. This review summarizes the mechanisms and regulators of ferroptosis, presents detection approaches and applications, and discusses future prospects and challenges for therapeutic development.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Biomedical
Wenxi Li, Jie Yan, Hao Tian, Bei Li, Guohao Wang, Wei Sang, Zhan Zhang, Xuanjun Zhang, Yunlu Dai
Summary: The interaction between PD-1 and PD-L1 in malignant melanoma cells promotes tumorigenesis, angiogenesis, and radio-resistance through mTOR hyperactivation. Blocking PD-L1 and mTOR signaling concurrently, along with radiotherapy, can alleviate tumor burden. A three-pronged platinum@polymer-catechol nanobraker, delivering mTOR inhibitor TAK228 and anti-PD-L1 antibody, effectively inhibits melanoma-PD-1-driven aggression and enhances melanoma eradication, while also amplifying the efficacy of radiotherapy.
BIOACTIVE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Wei Sang, Ruiping Zhang, Xiangyang Shi, Yunlu Dai
Summary: Nanofibers are wire-like materials with nanoscale diameters and specific length diameter ratios. Metallized nanofibers enhance the performance of conventional nanofibers through electrostatic spinning doping, chemical modification, and loading approaches. Due to their unique physical and chemical properties, metallized nanofibers have diverse applications in physical chemistry, materials science, and battery preparation, and are gradually expanding into the biomedical field.
Review
Chemistry, Multidisciplinary
Xuanbo Zhang, Bowei Yang, Qianqian Ni, Xiaoyuan Chen
Summary: Cancer vaccines have become an effective tool for cancer immunotherapy, and adjuvants play a crucial role in enhancing immune response. The success of adjuvants in developing stable and immunogenic cancer vaccines has sparked interest in adjuvant development. Advances in materials science offer insights into the rational design of vaccine adjuvants for topical cancer immunotherapy, including molecular adjuvants, polymers/lipids, inorganic nanoparticles, and bio-derived materials. Understanding the physicochemical features of these materials and their engineering strategies can help optimize the effects of adjuvants.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Nanoscience & Nanotechnology
Cuibing Bai, Jie Zhang, Wen Ma, Junxiong Yao, Qian Meng, Zhenni Xia, Dashuo Chen, Shuping He, Lin Zhang, Changqing Qu, Rui Qiao, Zhen Yang, Wei Huang
Summary: In this study, a new CN--activatable fluorescent probe, AHMM, was designed with a large Stokes shift and molecular structural reversible detection, overcoming the limitations of other fluorescent probes for CN- detection. AHMM exhibits excellent selectivity for CN- without interference from other anions in an aqueous DMSO system. Moreover, AHMM can quantitatively recognize CN- in tap water and visualize CN- in food samples and biological samples through fluorescence imaging.
Article
Chemistry, Multidisciplinary
Pengfei Zhang, Sheng Yao, Yu Tang, Shanhe Wan, Xiaoyuan Chen, Li Ma
Summary: In this study, a new palliative interventional therapy, nanoparticle-mediated microknife ablation, was developed to eliminate local cancer pain and tumors. Compared to classic chemotherapeutic agents, this therapy showed higher effectiveness in pain removal without damaging the nervous, sensory, and motor capabilities.
Article
Chemistry, Multidisciplinary
Jianping Liu, Jiezhao Zhan, Ye Zhang, Lin Huang, Jing Yang, Jie Feng, Lingwen Ding, Zheyu Shen, Xiaoyuan Chen
Summary: In this study, a facile method for synthesizing ultrathin manganese-based layered double hydroxide nanosheets is proposed, which enhances the interaction between ferroptosis and immunotherapy, overcoming the obstacles in current cancer immunotherapy.
ADVANCED MATERIALS
(2023)