期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 16, 期 11, 页码 1314-1342出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026615666150915111434
关键词
Bispidine; cytisine; 3,7-diazabicyclo[3.3.1]nonane; radiotracer; receptor; scaffold; sparteine
资金
- National Institute of General Medical Sciences, National Institutes of Health [P20GM 103466]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM103466] Funding Source: NIH RePORTER
The diazabicyclic molecule bispidine named by the chemist Carl Mannich in 1930, is a naturally occurring scaffold with interesting features. Bispidine can form different conformers, has high basicity, can attack dichloromethane, has metal ion coordination properties and interacts with nicotinic acetylcholine receptors. In this review we will discuss important properties, synthetic pathways and biological activities of bispidine and some derivatives. Bispidine can function as a scaffold for compounds with very diverse biological activities, e.g. interacting with ion channels, G-protein coupled receptors, and enzymes, and is even used for the development of new in vivo radiotracers.
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