期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 17, 期 4, 页码 498-506出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026616666160824121935
关键词
Adamantyl chalcones; Antimicrobial activity; Antifungal activity; Anticancer activity; MiaPaca2; NMR
Background: A new variety of adamantyl chalcones (2, 3a-o) were efficiently prepared by Claisen-Schmidt reaction of 4-adamantyl acetophenone 2 with a serie of aromatic aldehydes in good yields. Their structures were confirmed by spectroscopic data, and the relative configuration of 3d was confirmed by X-ray crystallography. All synthesized chalcones were tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus and displayed strong antibacterial activity against Enterococcus faecali 29212, Pseudomonas aeruginosa ATCC27853, Escherichia coli and interesting antifungal activity against Candida glabrata ATCC 90030. Result: The effect of these compounds was also tested in vitro as antitumor on Miapaca2 cells. Compounds also showed anticancer activity against human pancreas cancer cell MiaPaca2.
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