Article
Oncology
Michelle Treasure, Barbara Daly, Shufen Cao, Pingfu Fu, Augustine Hong, Elizabeth Weinstein, Jessica Surdam, Neal J. Meropol, Afshin Dowlati
Summary: This study compared differences in study duration, symptom burden, adverse events, and quality of life between phase 1 clinical trial patients receiving structured palliative care versus usual supportive care. Results showed that structured palliative care was associated with longer study duration and improved quality of life for patients and caregivers, with fewer adverse events experienced in the palliative care group.
Article
Psychology, Multidisciplinary
Astrid Schnabel, Florian Lordick, Paula Oberth, Markus Neuschulz, Antje Lehmann-Laue, Anja Mehnert-Theuerkauf, Andreas Hinz
Summary: This study analyzed the relationship between supportive care needs (SCNs), satisfaction with quality of life (QoL) dimensions, and the perceived importance of these dimensions among 152 cancer patients receiving palliative care. The results showed that the greatest SCNs were observed for absence of pain, while the patients were least satisfied with their physical functioning and the dimension social relationships received the highest perceived importance ratings.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Clinical Neurology
Natalie E. Stec, Tobias Walbert
Summary: The diagnosis of a brain tumor is a life-changing event for patients and their families. Though treatment advances have been made, malignant brain tumors remain incurable and have limited long-term survival. Patients experience a high symptom burden and require palliative interventions to maintain quality of life. Advance care planning is crucial in the terminal phase of illness.
NEUROLOGICAL SCIENCES
(2022)
Article
Biophysics
Ashley M. Nelson, P. Connor Johnson, Alison R. Kavanaugh, Vicki A. Jackson, Annemarie D. Jagielo, Alyssa L. Fenech, Matthew J. Reynolds, Carlisle Topping, Alisha M. Yi, Nora Horick, Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri
Summary: An inpatient palliative care intervention during HCT improved patient QOL and mood. Components of the intervention, differences in supportive care practices, and their mediation on patient outcomes were examined. While patients in the intervention group were more likely to use specific medications, these did not mediate the intervention's impact on patient-reported outcomes. Further research is needed to explore the mechanisms through which palliative care intervention affects QOL and mood.
BONE MARROW TRANSPLANTATION
(2021)
Article
Health Care Sciences & Services
Clea Atkinson, Sian Hughes, Len Richards, Victor Mf Sim, Julie Phillips, Imogen J. John, Zaheer Yousef
Summary: This study aims to create and evaluate a cospeciality cross-boundary service model that better provides for the palliative care needs of patients with HF in the latter stages of life, while delivering a more cost-effective patient journey.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2022)
Article
Nursing
Hyekyung Kim, Yang-Sook Yoo
Summary: This study investigated the supportive care needs of colorectal cancer survivors in South Korea and found that healthcare staff and social support needs were the highest, with about 20% of patients experiencing anxiety and depression. The results indicated that the time after treatment and anxiety significantly influenced supportive care needs.
ASIAN NURSING RESEARCH
(2021)
Review
Oncology
Fulvio Massaro, Fabio Andreozzi, Charlotte Vandevoorde, Dominique Bron
Summary: Lymphoproliferative disorders are frequently seen in the elderly population and their treatment options can have negative effects on their quality of life. Personalized management, supportive therapy, and preventive measures can improve both oncological outcomes and quality of life. It is important to involve the patient in the treatment decision-making process and consider the risk/benefit ratio. Decline in quality of life is a significant concern and interventions targeting vulnerabilities detected in older patients, along with optimal approaches to reduce treatment-related toxicity and mortality, can lead to improved quality of life.
Article
Health Care Sciences & Services
Yanting Li, Weiling Yang, Yuanyuan Qu, Xiaonan Zhang, Mei Lin, Li Fu, Cuicui Wang, Pingping Qiu, Xiaoying Zang
Summary: The study aimed to evaluate the effects of an autonomy-supportive intervention program on self-care, quality of life, and mental health in patients with heart failure. The results showed that the 8-week intervention significantly improved self-care, quality of life, mental health, and motivation in the patients.
QUALITY OF LIFE RESEARCH
(2023)
Article
Urology & Nephrology
Petros Grivas, Evgeny Kopyltsov, Po-Jung Su, Francis X. Parnis, Se Hoon Park, Yoshiaki Yamamoto, Peter C. Fong, Christophe Tournigand, Miguel A. Climent Duran, Aristotelis Bamias, Claudia Caserta, Jane Chang, Paul Cislo, Alessandra di Pietro, Jing Wang, Thomas Powles
Summary: This study compared the efficacy of first-line maintenance plus best supportive care with that of best supportive care alone in patients with advanced urothelial carcinoma. The results showed that the addition of first-line maintenance treatment significantly prolonged overall survival and had a minimal impact on quality of life.
Article
Health Care Sciences & Services
Andreas Hinz, Antje Lehmann-Laue, Diana Richter, Michael Hinz, Evelyn Goerz, Thomas Schulte, Anja Mehnert-Theuerkauf
Summary: The study aimed to analyze the relationship between quality of life (QoL) and supportive care needs (SCNs) in cancer patients. A short questionnaire with eight dimensions was developed to uniformly measure SCNs, QoL, and the subjective importance of these dimensions. The results showed that physical functioning received the highest SCN assessments, while autonomy and social relationships had the lowest SCN mean scores. There were gender-specific SCN patterns and the importance of dimensions did not consistently correlate with SCNs. The study highlights the value of a unified assessment instrument for SCNs and QoL in informing future cancer care strategies.
Article
Oncology
Antoine Arnaud, Julien Grenier, Rania Boustany, Sylvie Kirscher, Alice Mege, Gaetan de Rauglaudre, Lea Vazquez, Philippe Debourdeau
Summary: This study aimed to investigate the impact of comprehensive supportive care on the quality of life of metastatic breast cancer patients and found that patients with pain may benefit more. Factors associated with decreased unscheduled hospital care included age over 65, no previous treatment for metastatic breast cancer, and lack of comprehensive supportive care.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Marc Hilmi, Natacha Naoun, Alice Boileve, Arthur Geraud, Arnaud Bayle, Arnaud Pages, Marion Aupomerol, Matthieu Rouanne, Francois-Xavier Madec, Fanny Pommeret, Christophe Massard, Capucine Baldini, Florian Scotte, Stephane Champiat
Summary: This prospective study aims to assess supportive care needs, quality of life (QoL), and sexuality in patients enrolled in oncology phase 1 trials. The study found significant supportive care needs in certain subgroups of patients, and identified various factors that impact patients' QoL and sexual function.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Eran Ben-Arye, Dana Elly, Noah Samuels, Orit Gressel, Katerina Shulman, Elad Schiff, Ofer Lavie, Amir Minerbi
Summary: The study found that high adherence to integrative care was associated with greater pain relief at 6 weeks, but not at 12 weeks, in patients undergoing chemotherapy and/or palliative care.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Maria F. Paton, John Gierula, Judith E. Lowry, David A. Cairns, Kieran Bose Rosling, Charlotte A. Cole, Melanie McGinlay, Sam Straw, Rowena Byrom, Richard M. Cubbon, Mark T. Kearney, Klaus K. Witte
Summary: The study aimed to compare personalized pacemaker reprogramming with usual care on echocardiographic and patient-oriented outcomes. Results showed that personalized programming reduced RV pacing, improved LV function and size, and extended battery longevity, with no impact on quality of life.
Article
Nursing
Yun Young Choi, Sun Young Rha, Sungkun Cho, Hye Sun Lee, Bomi Hong, Jiyeon Lee
Summary: This study protocol aims to evaluate the effect of Enhanced Supportive Care, an early primary palliative care provided by nurses, on advanced cancer patients. The primary endpoints are symptoms, coping, and quality of life (QoL) at 3 months. This RCT will provide evidence of a strategy to implement early primary palliative care provided by nurses and improve cancer care for newly diagnosed patients with advanced stage cancer.
Article
Neurosciences
Jenny T. van der Steen, Carolien A. van Leussen, Joanne Ballentine, Loretta Gribben, Joanne Reid, Felicity Hasson, Kevin Brazil, B. Anne-Mei The, Dorry McLaughlin
Summary: Despite extensive knowledge on palliative care needs of individuals with dementia and their families, the successful implementation of models addressing these needs remains unclear. This study compares specialist models in the Netherlands (2017-2018) and Northern Ireland (2016-2017), highlighting the importance of recognizing roles and competencies among all stakeholders in developing effective partnership relationships. Referrals before end of life, along with a range of training programs, in-patient and out-patient services, and therapies, contribute to early benefits.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Medicine, General & Internal
William G. Herrington, Natalie Staplin, Christoph Wanner, Jennifer B. Green, Sibylle J. Hauske, Jonathan R. Emberson, David Preiss, Parminder Judge, Kaitlin J. Mayne, Sarah Y. A. Ng, Emily Sammons, Doreen Zhu, Michael Hill, Will Stevens, Karl Wallendszus, Susanne Brenner, Alfred K. Cheung, Zhi-Hong Liu, Jing Li, Lai Seong Hooi, Wen Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Cherney, Aldo P. Maggioni, Roberto Pontremoli, Rajat Deo, Shinya Goto, Xavier Rossello, Katherine R. Tuttle, Dominik Steubl, Michaela Petrini, Dan Massey, Jens Eilbracht, Martina Brueckmann, Martin J. Landray, Colin Baigent, Richard Haynes
Summary: Empagliflozin therapy reduces the risk of disease progression or cardiovascular death in patients with chronic kidney disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Urology & Nephrology
Laura J. Smyth, Katie R. Kerr, Jill Kilner, Aine E. McGill, Alexander P. Maxwell, Amy Jayne McKnight
Summary: This study analyzed the DNA methylation of kidney transplant recipients and identified markers associated with the risk of transplant complications. The findings provide an important reference for future epigenetic studies on posttransplant complications.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Nursing
Daniel Kelly, Zoe Horseman, Fiona E. Strachan, Sharon Hamilton, Aled Jones, Aisha Holloway, Anne Marie Rafferty, Helen Noble, Joanne Reid, Ruth Harris, Pam Smith
Summary: The aim of this study was to explore the challenges and opportunities faced by executive nurse directors in the UK and identify factors to strengthen their role and support more effective nurse leadership. The study involved qualitative descriptive research using reflexive thematic analysis, including interviews with nurse directors and their colleagues. The findings highlighted the unique complexity of the executive nurse director role and identified factors such as successful working relationships, development of political skills, coaching and mentoring, teamwork, and professional networks that can strengthen this role. The study has implications for the nursing profession and patient care, emphasizing the importance of recognizing and addressing the challenges faced by executive nurse leaders.
JOURNAL OF ADVANCED NURSING
(2023)
Article
Multidisciplinary Sciences
Wael Osman, Mira Mousa, Mohammed Albreiki, Zahrah Baalfaqih, Hinda Daggag, Claire Hill, Amy Jayne McKnight, Alexander P. Maxwell, Habiba Al Safar
Summary: Diabetic kidney disease (DKD), or diabetic nephropathy, is a major cause of renal impairment and end-stage renal disease. This study conducted a genome-wide association study to investigate genetic factors associated with the development and progression of DKD in the Emirati population. The CNR2 gene was found to be significantly associated with the development of DKD in individuals with type 2 diabetes mellitus (T2DM).
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Claire Hill, Seamus M. Duffy, Laura Kettyle, Liane McGlynn, Niina M. Sandholm, Rany Salem, Alex J. Thompson, Elizabeth Swan, Jill Kilner, Peter G. Rossing, Paul Shiels, Maria Lajer, Per-Henrik Groop, Alexander Peter Maxwell, Amy Jayne McKnight, GENIE Consortium
Summary: Diabetic kidney disease (DKD) is a major global health problem characterized by accelerated aging. This study explored features affecting telomere biology and methylation dysregulation in DKD using multi-omics approaches, which may provide useful biomarkers or therapeutic targets.
Review
Genetics & Heredity
Claire Hill, Seamus Duffy, Tiernan Coulter, Alexander Peter Maxwell, Amy Jayne McKnight
Summary: The global prevalence of diabetes is increasing and research is needed to find new ways to manage it. Diabetes can lead to kidney disease, which is a burden to patients and healthcare services. This review highlights studies on genomic and functional prediction tools that have identified genes and pathways associated with diabetic kidney disease, particularly focusing on the regulation of telomere length. The potential to use therapeutics that modulate telomere length for the treatment of diabetic kidney disease is discussed in the review.
Article
Urology & Nephrology
Norberto Perico, Giuseppe Remuzzi, Matthew D. Griffin, Paul Cockwell, Alexander P. Maxwell, Federica Casiraghi, Nadia Rubis, Tobia Peracchi, Alessandro Villa, Marta Todeschini, Fabiola Carrara, Bernadette A. Magee, Piero L. Ruggenenti, Stefano Rota, Laura Cappelletti, Veronica Mcinerney, Tomas P. Griffin, Md Nahidul Islam, Martino Introna, Olga Pedrini, Josee Golay, Andrew A. Finnerty, Jon Smythe, Willem E. Fibbe, Stephen J. Elliman, Timothy O'Brien, NEPHSTROM Trial Consortium
Summary: The NEPHSTROM study evaluates the safety, tolerability, and preliminary efficacy of ORBCEL-M cell therapy in adults with type 2 diabetes and progressive diabetic kidney disease. The results show that ORBCEL-M cell therapy is safe and well-tolerated in the lowest dose cohort, and significantly reduces the decline rate of eGFR over 18 months.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Nga T. Q. Nguyen, Aisling E. E. Courtney, Hoa Q. Q. Nguyen, Michael Quinn, Alexander P. P. Maxwell, Ciaran O'Neill
Summary: This study aimed to assign expanded criteria and non-expanded criteria donation status and examine early clinical and economic outcomes among expanded criteria and non-expanded criteria living kidney donor (LKD) hospitalizations in the US.
JOURNAL OF NEPHROLOGY
(2023)
Article
Health Care Sciences & Services
Cindy V. Mendieta, Esther de Vries, Jose Andres Calvache, Sam H. Ahmedzai, Gillian Prue, Tracey Mcconnell, Joanne Reid
Summary: This article introduces the implementation strategy workshop for SPARC-Sp in Colombia. Participants identified the need for PC education, clarification, and professional capacity building. They also recognized the need for adaptations to SPARC-Sp to address the low literacy of the population and specificities of the healthcare system in Colombia.
Article
Health Care Sciences & Services
Anna Wilson, Clare Mckeaveney, Claire Carswell, Karen Atkinson, Stephanie Burton, Clare Mcveigh, Lisa Graham-Wisener, Erika Jaaskelainen, William Johnston, Daniel O'Rourke, Joanne Reid, Soham Rej, Ian Walsh, Helen Noble
Summary: The Compassionate Mindful Resilience (CMR) program was found to be an acceptable intervention for people living with kidney disease, providing tools and techniques to support their mental health and well-being. Participants reported subjective benefits and positive experiences with the program.
Review
Urology & Nephrology
Anna Rainey, Gareth J. Mckay, Jane English, Ammarin Thakkinstian, Alexander Peter Maxwell, Michael Corr
Summary: Kidney transplantation is the optimal treatment for most patients with end-stage kidney disease, but rejection and graft failure remain common. The development of non-invasive biomarkers to monitor graft function and predict transplant outcomes is still needed. Proteomic investigation has identified potential biomarkers, but their clinical translation and adoption are limited and require further evaluation in larger trials.
Article
Health Care Sciences & Services
Carolyn Blair, Adrian Slee, Andrew Davenport, Denis Fouque, William Johnston, Kamyar Kalantar-Zadeh, Peter Maxwell, Clare McKeaveney, Robert Mullan, Helen Noble, Sam Porter, David Seres, Joanne Shields, Ian Swaine, Miles Witham, Joanne Reid
Summary: This study aimed to develop a theoretical framework for a multimodal intervention for patients with renal cachexia. The researchers used a Theory of Change approach to guide the development of the framework and provide evidence for the effectiveness of the intervention.
