Review
Chemistry, Physical
Saman Sargazi, Ushna Laraib, Mahmood Barani, Abbas Rahdar, Iqra Fatima, Muhammad Bilal, Sadanad Pandey, Rakesh K. Sharma, George Z. Kyzas
Summary: The shape of nanoparticles is crucial for drug delivery efficiency. Rod-shaped mesoporous silica nanoparticles (RMSNs) have shown advantages over spherical MSNs in targeted drug delivery. RMSNs have desirable properties such as biocompatibility, low toxicity, large surface area, and stability, making them a perfect nanostructure. They have been utilized in various applications including bioimaging, cancer treatment, and drug/gene delivery.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Xuan He, Fangman Chen, Zhimin Chang, Kasim Waqar, Hanze Hu, Xiao Zheng, Yingshuai Wang, Wen-fei Dong, Chao Yang
Summary: This review comprehensively discusses the recent progress in the fabrication and application of silver mesoporous silica nanoparticles (Ag-MSNs) for combination therapies for cancer and infection. Different structures of Ag-MSNs are elaborated, and their applications in imaging, therapy, and antibacterial treatment are highlighted. The challenges and future directions are also summarized.
Review
Chemistry, Inorganic & Nuclear
Qingqing Xu, Yuanqi Yang, Junya Lu, Yuanzhe Lin, Shuaipeng Feng, Xinyi Luo, Donghua Di, Siling Wang, Qinfu Zhao
Summary: Nanodynamic therapies using nanosensitizers triggered by various activators or reactions in tumor microenvironment have emerged as attractive strategies for treating deep-seated tumors. Mesoporous silica nanoparticles (MSNs) and MSNs-based hybrid nanoparticles are promising candidates for nanodynamic therapies due to their large surface area, high pore volume, biosafety, and easy surface modification. This review summarizes the antitumor mechanisms and latest progress in the construction, modification, and application of MSNs-based nanodynamic therapies, including photodynamic therapy, chemodynamic therapy, sonodynamic therapy, thermodynamic therapy, radiodynamic therapy, and electrodynamic therapy. The challenges and prospects for clinical applications of MSNs-based ROS-activated cancer treatments are also discussed.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Alex N. Frickenstein, Jordan M. Hagood, Collin N. Britten, Brandon S. Abbott, Molly W. McNally, Catherine A. Vopat, Eian G. Patterson, William M. MacCuaig, Ajay Jain, Keisha B. Walters, Lacey R. McNally
Summary: Mesoporous silica nanoparticles (MSNs) are being extensively researched for their theragnostic potential in treating and diagnosing various malignancies, showing significant efficacy in preclinical models. Understanding the characteristics of effective MSNs is crucial for their successful translation into clinical practice and improving clinical outcomes.
Review
Chemistry, Multidisciplinary
Kaili Wang, Junya Lu, Jiali Li, Yinlu Gao, Yuling Mao, Qinfu Zhao, Siling Wang
Summary: Photoactivated therapeutic strategies such as photothermal therapy and photodynamic therapy have become prevalent for fighting tumors, with mesoporous silica nanoparticles showing promise for multimodal cancer therapy. However, challenges remain in the application of these therapies for deep-seated tumors.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biochemical Research Methods
Jorge Parra-Nieto, Maria Amor Garcia del Cid, Inigo Aguirre de Carcer, Alejandro Baeza
Summary: The use of porous inorganic nanoparticles in oncology for delivering chemotherapeutic agents shows great potential by utilizing specific targeting moieties to achieve selective uptake in malignant cells and controlled drug release, benefiting from their excellent cargo capacity, biocompatibility, and precise control over drug release behavior.
BIOTECHNOLOGY JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Periyanaina Kesika, Natarajan Suganthy, Chaiyavat Chaiyasut
Summary: Complete recovery from infection, sepsis, injury, or trauma requires a vigorous inflammatory response. Nanoparticles have become an efficient medical tool for diagnosing, preventing, and treating diseases due to their unique interactions with biological molecules. Mesoporous silica nanoparticles (MSNs) play a significant role in nano therapy and have several advantages such as easy synthesis, loading, and biocompatibility. MSNs can be used as theranostics in immune-modulatory nano systems to diagnose and treat inflammatory diseases.
Review
Pharmacology & Pharmacy
Panoraia Siafaka, Neslihan Ustundag Okur, Ioannis D. Karantas, Mehmet Evren Okur, Evren Atlihan Gundogdu
Summary: Nanotheranostics, as emerging diagnostic and therapeutic tools, have gained attention in the past decade for their targeted treatment and diagnostic properties, allowing real-time monitoring of therapy response and reducing the risk of dosage errors. Various imaging techniques are used for monitoring drug delivery processes, with radiolabeling of nanomaterials widely used in nuclear medicine imaging.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Indika Chandrasiri, Mahesh Loku Yaddehige, Bo Li, Yuzhe Sun, William E. Meador, Austin Dorris, Mohammad Farid Zia, Nathan Hammer, Alex Flynt, Jared H. Delcamp, Edward Davis, Alexander Lippert, Davita L. Watkins
Summary: This study compares the solution behavior and self-assembly pattern of two linear dendritic block copolymers (LDBCs) and finds that the introduction of phenyl substituents improves the stability and loading efficiency of LDBC nanoparticles, which shows great potential for use as nanocarriers in therapeutic nanomedicine.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Xuexin Li, Weiyuan Li, Mina Wang, Zehuan Liao
Summary: Nanoparticles have emerged as a novel approach in cancer diagnosis and treatment, showing great potential in medical applications. However, more research is needed to improve their toxicity and efficacy for clinical use.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Alba Garcia-Fernandez, Felix Sancenon, Ramon Martinez-Manez
Summary: Respiratory diseases have become a major clinical concern worldwide and nanomedicine shows promise in overcoming the limitations of current lung therapies by enhancing drug bioavailability and reducing side effects. However, more efforts are needed to achieve effective pulmonary drug delivery despite the different approaches that have been developed.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Suphalak Khamruang Marshall, Pavimol Angsantikul, Zhiqing Pang, Norased Nasongkla, Rusnah Syahila Duali Hussen, Soracha D. Thamphiwatana
Summary: The development of biomimetic drug delivery systems using cell membrane as a surface coating has attracted research attention. In this study, human red blood cell (RBC) membrane-coated nanoparticles were designed as a targeted nanotheranostic against cancer. The nanoparticles showed enhanced targeting functionality and prolonged drug release. The TT-RBC-NPs platform achieved targeted drug delivery and visualization of cancer cells, with increased cellular uptake and enhanced cytotoxic efficacy.
Review
Biochemistry & Molecular Biology
Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura
Summary: Nanoparticles, particularly silica nanoparticles, have shown significant potential in light-based nanomedicine, offering advantages for in vivo imaging and therapy, including cancer treatment. The unique structural and functional properties of silica nanoparticles make them promising in the integration of light-based diagnostics and therapeutics, leading to advancements in cancer photo-theranostics.
Article
Biochemistry & Molecular Biology
Lara G. Freidus, Pradeep Kumar, Thashree Marimuthu, Priyamvada Pradeep, Yahya E. Choonara
Summary: A novel theranostic molecule termed CurNQ, derived from Cur and NQ, has been synthesized and loaded into mesoporous silica nanoparticles to form MSN_CurNQ, which showed enhanced drug delivery and pH-responsive release of CurNQ. The fluorescence characteristics of MSN_CurNQ allow for tracking and detection, while its chemotherapeutic potential was demonstrated in vitro, particularly in cancer cell lines with tumor-specific toxicity. The novel nanosystem MSN_CurNQ holds promise for applications in cancer targeting, detection, and treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Engineering, Chemical
Pragya Pallavi, Karthick Harini, Sultan Alshehri, Mohammed M. M. Ghoneim, Areej Alshlowi, Pemula Gowtham, Koyeli Girigoswami, Faiyaz Shakeel, Agnishwar Girigoswami
Summary: The advancements in nanotechnology have led to the development of nanostructured materials with wide applications in medicine and pharmaceuticals. Silica nanoparticles (SNPs) are particularly promising due to their large surface-to-volume ratio, ease of surface modification, and tunable pore size. This review discusses the preparation of SNPs and their various applications in medical fields, including drug delivery, imaging, and phototherapy. The potential harmful effects of SNPs are also reviewed based on in vitro and in vivo experiments. Furthermore, the engineering of SNPs for theranostic applications is highlighted as a way to overcome limitations of traditional therapeutics and diagnostics.
Article
Biology
Jesus L. Pablos, Monica Cicuendez, Maria Hernandez-Rivas, Fernando Catalina, Maria Vallet-Regi, Teresa Corrales
Summary: The study focuses on the preparation of new biomaterials by blending PCL and PEC, and investigates their potential application in bone regeneration through in vitro biocompatibility tests. The characterization of the blends reveals that increasing the content of PEC improves the mechanical properties and hydrophilic character of the materials, which in turn leads to enhanced biological properties. The assessment of cell viability, proliferation, and differentiation demonstrates that the PCL/PEC blends exhibit favorable cell response for bone tissue regeneration. The results suggest that the PCL/PEC blends have the potential for in vivo testing and real-life application in bone regeneration.
Article
Engineering, Biomedical
Sandra Sanchez-Salcedo, Ana Garcia, Adela Gonzalez-Jimenez, Maria Vallet-Regi
Summary: The development of biomaterials with high bioactivity and antibacterial properties for bone tissue regeneration is investigated. Nanocomposites of mesoporous bioactive glasses doped with silver nanoparticles were synthesized and used to fabricate three-dimensional scaffolds. The presence of silver nanoparticles inhibited bacterial growth and showed potential applications in bone tissue regeneration. The innovative methodology combined the sol-gel method and rapid prototyping technique.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Jorge Parra-Nieto, Maria Amor Garcia del Cid, Carolina Galeano, Inigo Aguirre de Carcer, Lorena Garcia-Garcia, Africa Gonzalez-Murillo, Diego Megias, Manuel Ramirez, Alejandro Baeza
Summary: This study reports the development of a multifunctional nanoplatform based on the assembly of protocells and polymeric nanocapsules, which can deliver cytotoxic drugs and enzymes to specific tumor tissues, effectively improving therapeutic outcomes. The nanoplatform exhibited significantly higher cytotoxic activity in neuroblastoma cells.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Engineering, Biomedical
Carla Jimenez-Jimenez, Almudena Moreno-Borrallo, Bianca Dumontel, Miguel Manzano, Maria Vallet-Regi
Summary: Nanotechnology has revolutionized potential disease treatments, but immune clearance and poor biocompatibility limit the use of nanoparticles for drug delivery. Coating nanoparticles with cell membranes is a hypothesis to overcome rejection and enhance biocompatibility. Here, we show that coating mesoporous silica nanoparticles with membranes from preosteoblastic cells can be used for potential bone disease treatments. Our results demonstrate the cellular selectivity and migration capability of camouflaged nanocarriers, which inspire future treatments.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Miguel Gisbert-Garzaran, Maria Natividad Gomez-Cerezo, Maria Vallet-Regi
Summary: Bone diseases have become a global public concern, affecting millions of people. Although current treatments are effective, they come with side effects. To address this, the development of biocompatible nanoparticles and macroscopic scaffolds has shown promise in improving bone regeneration while reducing side effects. This review highlights the emerging trend of materials that specifically recognize agents in the bone microenvironment, showcasing examples of modified nanoparticles and scaffolds. The potential of these bone-targeting agents to revolutionize the treatment of bone-related diseases is discussed, providing a comprehensive overview of the field's state-of-the-art.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Javier Jimenez-Holguin, Daniel Arcos, Daniel Lozano, Melchor Saiz-Pardo, David de Pablo, Luis Ortega, Silvia Enciso, Blanca Fernandez-Tome, Idoia Diaz-Guemes, Francisco Miguel Sanchez-Margallo, Laura Casarrubios, Maria Teresa Portoles, Maria Vallet-Regi
Summary: The study synthesized zinc-enriched mesoporous bioactive glasses and evaluated their osteogenic properties in vitro and in vivo. The in vitro assays showed a correlation between zinc content and cell differentiation and angiogenesis. However, despite their good structural properties and cellular response in vitro, the zinc glasses were unable to integrate with bone tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Bianca Dumontel, Veronica Conejo-Rodriguez, Maria Vallet-Regi, Miguel Manzano
Summary: In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with responsive pore gatekeepers has shown potential for drug delivery systems (DDS) with controlled release. The use of natural biopolymers as smart materials in drug delivery applications has been investigated extensively. This review summarizes the coating procedures with natural polysaccharides and protein-based biopolymers, focusing on their application as responsive materials to endogenous stimuli. Biopolymer-coated MSNs have shown promising therapeutic outcomes and potential for selective treatment of various diseases.
Article
Pharmacology & Pharmacy
Ana Arenas-Vivo, Vanessa Celis Arias, Georgiana Amariei, Roberto Rosal, Isabel Izquierdo-Barba, Tania Hidalgo, Maria Vallet-Regi, Hiram I. Beltran, Sandra Loera-Serna, Patricia Horcajada
Summary: Surface microbial colonization and biofilm formation are major problems causing human infectious diseases, and traditional treatments are often ineffective in eliminating biofilms. This study presents a silver-based metal-organic framework (AgBDC) that has antifouling properties and can prevent bacterial adhesion and surface contamination.
Article
Chemistry, Analytical
Guillermo Aragoneses-Cazorla, Maria Vallet-Regi, Ma. Milagros Gomez-Gomez, Blanca Gonzalez, Jose L. Luque-Garcia
Summary: A combination of transcriptomics and metabolomics was used to study the mechanisms behind the antitumor action of a nanosystem called Ag@MSNs-Tf. Transcriptomics analysis was done using gene microarrays and RT-qPCR, while metabolomics analysis was done using high-resolution mass spectrometry. This multiomics approach revealed the impact of the nanosystem on various molecular pathways, including glycolysis, the pentose phosphate pathway, oxidative phosphorylation, and fatty acid synthesis.
Review
Chemistry, Multidisciplinary
Daniel Lozano, Vicente Larraga, Maria Vallet-Regi, Miguel Manzano
Summary: Vaccines are a major advancement in public health, preventing illness and death in millions of people each year. The use of nanotechnology has revolutionized vaccine development, with nanoparticles emerging as promising carriers for future vaccines. Despite significant progress in nanoparticle vaccine research, only a few have advanced to clinical investigation and usage so far.
Article
Pharmacology & Pharmacy
Daniel Lozano, Beatriz Leiva, Ines S. Gomez-Escalonilla, Sergio Portal-Nunez, Arancha R. de Gortazar, Miguel Manzano, Maria Vallet-Regi
Summary: Osteoporosis is commonly treated with antiresorptive drugs and anabolic agents, but these treatments have limitations. Pleiotrophin (PTN), a protein involved in tissue repair, and mesoporous silica nanoparticles (MSNs), a drug-delivery system, have shown potential for improving bone regeneration. In this study, PTN-loaded MSNs significantly enhanced osteogenesis and osteoblast differentiation when tested on MC3T3-E1 cells and human mesenchymal stem cells. This proof of concept suggests that MSNs can effectively deliver PTN and may be a promising treatment for osteoporosis and bone-regeneration scenarios.
Article
Polymer Science
Jesus L. Pablos, Javier Jimenez-Holguin, Sandra Sanchez Salcedo, Antonio J. Salinas, Teresa Corrales, Maria Vallet-Regi
Summary: The production of customized polymeric hydrogels in the form of 3D scaffolds with application in bone tissue engineering is currently a topic of great interest. Based on gelatin methacryloyl (GelMa) as one of the most popular used biomaterials, GelMa with two different methacryloylation degrees (DM) was obtained, to achieve crosslinked polymer networks by photoinitiated radical polymerization.
Article
Chemistry, Physical
Montserrat Colilla, Maria Vallet-Regi
Summary: Bacterial antimicrobial resistance is a major threat to global health, and the stalled antibiotic research pipeline has worsened the situation. Nanotechnology offers a potential solution by using nanocarriers to transport and deliver antimicrobials to overcome bacterial resistant barriers. Mesoporous silica nanoparticles (MSNs) have attracted attention due to their unique features. This perspective article outlines recent research in the design and development of organically modified MSNs to fight bacterial infections, addressing the current challenges and future perspectives.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Laura Casarrubios, Monica Cicuendez, Maria Vallet-Regi, Maria Teresa Portoles, Daniel Arcos, Maria Jose Feito
Summary: Bioactive mesoporous glass nanospheres (nanoMBGs) loaded with ipriflavone can produce positive immune effects, which have great potential for the treatment of osteoporosis and fracture prevention.
Article
Engineering, Biomedical
Bianca Dumontel, Carla Jimenez-Jimenez, Maria Vallet-Regi, Miguel Manzano
Summary: The integration of artificial nanoplatforms with natural bio-materials has led to the development of more efficient drug delivery systems. In this study, mesoporous silica nanoparticles (MSNs) were combined with tumor derived extracellular vesicles (EVs) to create a hybrid nanosystem that showed selective cellular internalization and enhanced intracellular drug accumulation, making it a promising candidate for targeted treatments.
MATERIALS TODAY BIO
(2023)
