Barriers to Implementing Clinical Pharmacogenetics Testing in Sub-Saharan Africa. A Critical Review

Careful governance of African biobanks

(2020) Alan Christoffels et al.   LANCET

Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience

(2020) Christina L Aquilante et al.   PHARMACOGENOMICS

Polygenic risk scores: from research tools to clinical instruments

(2020) Cathryn M. Lewis et al.   Genome Medicine

Pan-African genome

(2019) Nicole Rusk   NATURE METHODS

Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection

(2019) Simon Marie Peko et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing

(2019) Larisa H. Cavallari et al.   GENETICS IN MEDICINE

No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples

(2019) Richard Border et al.   AMERICAN JOURNAL OF PSYCHIATRY

Germline variants and somatic mutation signatures of breast cancer across populations of African and European ancestry in the US and Nigeria

(2019) Shengfeng Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Targeted ultra-deep sequencing of a South African Bantu-speaking cohort to comprehensively map and characterize common and novel variants in 65 pharmacologically-related genes

(2019) Sibongile Tshabalala et al.   Pharmacogenetics and Genomics

Systematic review of the evidence on the cost-effectiveness of pharmacogenomics-guided treatment for cardiovascular diseases

(2019) Ye Zhu et al.   GENETICS IN MEDICINE

A framework for tiered informed consent for health genomic research in Africa

(2019) Victoria Nembaware et al.   NATURE GENETICS

Burden of non-communicable diseases in sub-Saharan Africa, 1990–2017: results from the Global Burden of Disease Study 2017

(2019) Hebe N Gouda et al.   Lancet Global Health

Genetic Factors Influencing Warfarin Dose in Black‐African Patients: A Systematic Review and Meta‐Analysis

(2019) Innocent G. Asiimwe et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Accurately genotyping CYP2D6: not for the faint of heart

(2018) Charity Nofziger et al.   PHARMACOGENOMICS

Combination of CYP2C19 genotype with non-genetic factors evoking phenoconversion improves phenotype prediction

(2018) Ádám Ferenc Kiss et al.   Pharmacological Reports

Ethical, social, and cultural issues related to clinical genetic testing and counseling in low- and middle-income countries: a systematic review

(2018) Adrina Zhong et al.   GENETICS IN MEDICINE

An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C

(2018) Nyarai Desiree Soko et al.   PHARMACOGENOMICS JOURNAL

An optimized prediction framework to assess the functional impact of pharmacogenetic variants

(2018) Yitian Zhou et al.   PHARMACOGENOMICS JOURNAL

Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations

(2018) Worku Bedada et al.   Scientific Reports

Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites

(2018) Eric H Decloedt et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women

(2017) Ritah F. Mutagonda et al.   MALARIA JOURNAL

Methodological and Ethical Issues in Pediatric Medication Safety Research

(2017) Delesha Carpenter et al.   PEDIATRICS

Systematic evaluation of commercial pharmacogenetic testing in psychiatry

(2017) Chad A. Bousman et al.   Pharmacogenetics and Genomics

Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study

(2017) Mamoonah Chaudhry et al.   PHARMACOGENOMICS

Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans

(2017) Ananyo Choudhury et al.   Nature Communications

African Genetic Diversity: Implications for Cytochrome P450-mediated Drug Metabolism and Drug Development

(2017) Iris Rajman et al.   EBioMedicine

Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicity

(2016) Zelalem Petros et al.   BMC GENOMICS

Adverse Drug Reaction Reporting in Africa and a Comparison of Individual Case Safety Report Characteristics Between Africa and the Rest of the World: Analyses of Spontaneous Reports in VigiBase®

(2016) Haggar H. Ampadu et al.   DRUG SAFETY

Prediction of CYP2D6 phenotype from genotype across world populations

(2016) Andrea Gaedigk et al.   GENETICS IN MEDICINE

Influence of CYP3A5*3 and ABCB1 C3435T on clinical outcomes and trough plasma concentrations of imatinib in Nigerians with chronic myeloid leukaemia

(2016) B. A. Adeagbo et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Pharmacogenomics of Rosuvastatin: A Glocal (Global+Local) African Perspective and Expert Review on a Statin Drug

(2016) Nyarai D. Soko et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3′-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients

(2016) Marelize Swart et al.   Frontiers in Genetics

Racial/ethnic differences in drug disposition and response: Review of recently approved drugs

(2015) A Ramamoorthy et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacogenetics of pregnancy-induced changes in efavirenz pharmacokinetics

(2015) A Olagunju et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effects ofCYP2B6andCYP1A2Genetic Variation on Nevirapine Plasma Concentration and Pharmacodynamics as Measured by CD4 Cell Count in Zimbabwean HIV-Infected Patients

(2015) Doreen Mhandire et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Pharmacogenomic variants have larger effect sizes than genetic variants associated with other dichotomous complex traits

(2015) J C Maranville et al.   PHARMACOGENOMICS JOURNAL

CYP2B6*6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response in HIV-malaria-coinfected patients

(2015) B A Maganda et al.   PHARMACOGENOMICS JOURNAL

Perception of the Usefulness of Drug/Gene Pairs and Barriers for Pharmacogenomics in Latin America

(2014) Luis Quinones et al.   CURRENT DRUG METABOLISM

The African Genome Variation Project shapes medical genetics in Africa

(2014) Deepti Gurdasani et al.   NATURE

CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network

(2011) M V Relling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effect of Rifampicin and CYP2B6 Genotype on Long-Term Efavirenz Autoinduction and Plasma Exposure in HIV Patients With or Without Tuberculosis

(2011) E Ngaimisi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Evaluation of the effects of VKORC1 polymorphisms and haplotypes, CYP2C9 genotypes, and clinical factors on warfarin response in Sudanese patients

(2011) Nassr Eldin M. A. Shrif et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C

(2011) Tarik Asselah et al.   JOURNAL OF HEPATOLOGY

Novel CYP2C9 and VKORC1 gene variants associated with warfarin dosage variability in the South African black population

(2011) Cathrine Mitchell et al.   PHARMACOGENOMICS

CULTURE AND GENETIC SCREENING IN AFRICA

(2009) AYODELE S. JEGEDE   Developing World Bioethics

The Genetic Structure and History of Africans and African Americans

(2009) S. A. Tishkoff et al.   SCIENCE

Pharmacogenetics: From Bench to Byte

(2008) JJ Swen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Establishment of a biobank and pharmacogenetics database of African populations

(2008) Alice Matimba et al.   EUROPEAN JOURNAL OF HUMAN GENETICS