Article
Pharmacology & Pharmacy
Laxman Subedi, Prashant Pandey, Jung-Hyun Shim, Ki-Taek Kim, Seung-Sik Cho, Kyo-Tan Koo, Beum Joon Kim, Jin Woo Park
Summary: This study developed an ideal topical formulation of bimatoprost (BIM) and demonstrated its effectiveness in promoting hair regrowth and increasing hair coverage by improving skin permeability and drug deposition. Furthermore, the formulation was found to activate human dermal papilla cell proliferation and has potential in treating scalp alopecia.
Review
Pharmacology & Pharmacy
Khushbakht Saleem, Bazla Siddiqui, Asim Ur Rehman, Malik Mumtaz Taqi, Naveed Ahmed
Summary: Androgenic alopecia is a progressive hair loss disease, with the commonly used treatment drug MIN associated with adverse reactions. Researchers have developed nanocarriers to improve therapeutic outcomes, but there is still limited data on loading in final dosage forms.
Article
Pharmacology & Pharmacy
Sultan Pulat, Laxman Subedi, Prashant Pandey, Suresh R. Bhosle, Jae-Seoun Hur, Jung-Hyun Shim, Seung-Sik Cho, Ki-Taek Kim, Hyung-Ho Ha, Hangun Kim, Jin Woo Park
Summary: Atraric acid (AA) is a phenolic compound derived from Stereocaulon japonicum and has anti-androgen properties, making it a viable alternative for treating alopecia. A new topical formulation, AA-TF#15, was designed using a solvent mixture system and showed significantly higher skin flux and dermal drug deposition compared to AA in ethanol. Furthermore, AA-TF#15 demonstrated the ability to activate keratinocytes and human dermal papilla cell proliferation, leading to increased hair regrowth compared to minoxidil and oral finasteride treatments.
Article
Pharmacology & Pharmacy
Xiang Liu, Feng Guo, Desheng Liang, Zilin Li, Yating Cao, Mengqi Chen, Jianjun Xu, Xinliang Liu, Haijun Zhong
Summary: This study developed a dermal topical delivery system called Finasteride niosomes (FIN-NIS) and evaluated its effectiveness in treating androgenetic alopecia (AGA) in vitro/in vivo. The results showed that FIN-NIS had a higher drug concentration in the hair follicle area compared to Finasteride solution and suspension, and it was even more effective than minoxidil. Therefore, FIN-NIS could be a promising dermal topical delivery system for enhancing the performance of Finasteride in AGA treatment and avoiding the risk of systemic side effects associated with oral administration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Breno N. Matos, Ana Luiza Lima, Camila O. Cardoso, Marcilio Cunha-Filho, Tais Gratieri, Guilherme M. Gelfuso
Summary: This study prepared polymeric and lipidic nanoparticles (PNPs and NLCs) co-entrapping minoxidil and betamethasone for follicular drug delivery. The nanoparticles showed suitable size and thermal stability, significantly increasing the penetration of minoxidil and betamethasone into the hair follicles and delivering higher concentrations of betamethasone. The nanoparticles are suitable for topical therapy and effectively target the hair follicles.
Article
Pharmacology & Pharmacy
Deepak Kumar Upadhyay, Amit Sharma, Navjot Kaur, Ghanshyam Das Gupta, Raj Kumar Narang, Vineet Kumar Rai
Summary: This study successfully developed a nanoemulgel for the topical administration of finasteride, demonstrating longer skin residence time, slow permeation, and higher efficacy against alopecia.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2021)
Review
Pharmacology & Pharmacy
Jia-Li Yao, Yu-Rou Shi, Xue-Er Hu, Dai-Jun Yu, Bang-Yao Chen, Li-Jiang Wang, Xiao-Ling Xu, Meng-Lu Zhu
Summary: Androgenic alopecia (AGA) is a common form of hair loss that can have significant psychological and quality of life impacts. Exosomes, particularly stem cell-derived exosomes, have shown potential in treating AGA by repairing damaged hair follicles and promoting follicular regrowth.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Oncology
Elwira Szychot, David Walker, Peter Collins, Harpreet Hyare, Ananth Shankar, Alison Bienemann, Milo Hollingworth, Steven Gill
Summary: The study demonstrated that using the Renishaw Drug Delivery System for intermittent CED of carboplatin and sodium valproate to the pons in DIPG patients was safe and well tolerated, resulting in improved control of pontine disease and longer progression-free survival and overall survival. Further evaluation in a clinical trial is warranted.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Simona Roxana Georgescu, Andreea Amuzescu, Cristina Iulia Mitran, Madalina Irina Mitran, Clara Matei, Carolina Constantin, Mircea Tampa, Monica Neagu
Summary: Platelet-rich plasma (PRP) therapy is a novel treatment that has been extensively tested and is increasingly used in dermatology and cosmetic surgery. It has shown significant effectiveness in treating androgenic alopecia (AGA).
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Li Hu, Xiaojiao Zhang, Fuling Luo, Hengguang Zhao
Summary: A man in his 50s with progressive hair thinning in the occipital area presented a novel isotype of male androgenetic alopecia (MAGA), named inverse-MAGA, which was identified based on his clinical features, trichoscopy findings, histological features, and response to conventional anti-MAGA therapeutic drugs. Further evaluation of this isotype should be conducted in future studies.
Article
Pharmacology & Pharmacy
Ying Sun, Yongxiang Zhang, Xiaxia Liu, Yan Tingting, Liyan Shen, Dan Ye, Xia Kong, Yonghui Su, Qingping Tian
Summary: Efforts were made to improve the drug content and entrapment efficiency of minoxidil in transfersomes for effective treatment of alopecia. The optimized transfersomes and its gel exhibited better transdermal penetration ability and hair growth-promoting capacity, making them a promising strategy for the topical treatment of alopecia.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Ooi Wan-En, Liew Yun-Ming, Heah Cheng-Yong, Ho Li Ngee, Mohd Mustafa Al Bakri Abdullah, Mohd Suhaimi Bin Khalid, Foo Kai Loong, Ong Shee-Ween, Tan Pei Seng, Hang Yong Jie, Khairunnisa Zulkifly
Summary: This study investigates the influence of various solid activators on the characteristics of greener one-part geopolymers based on high calcium fly ash. The results show that substituting Na2SiO3 with NaOH or Na2CO3 effectively produces a construction material with higher compressive strength and lower embodied carbon.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Pharmacology & Pharmacy
Asmaa A. Elshall, Amira M. Ghoneim, Nehad M. Abd-elmonsif, Rihab Osman, Dalia S. Shaker
Summary: The strategy of this work involved loading Melatonin (MEL), a powerful antioxidant photosensitive molecule, into novel Pickering emulsions (PEs) stabilized by chitosan-dextran sulphate nanoparticles (CS-DS NPs) and enhanced by lecithin for the treatment of androgenic alopecia (AGA). The study optimized the biodegradable CS-DS NPs dispersion for PEs stabilization and characterized the PEs for various properties. The results showed that the MEL-loaded PE exhibited improved antioxidant activity, photostability, and follicular delivery, making it a promising competitor to commercially marketed Minoxidil for AGA treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Sanketh Gehlot, Saritha Shetty
Summary: Androgenic alopecia is a common condition that affects 50% of the global population, with the incidence expected to increase by 60% in the coming decades. It has a significant impact on emotional health, mental health, and self-esteem. Electrospun nanofibers show promise in promoting hair growth and are an innovative approach in scalp repair.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Shuying Zhou, Fei Qi, Yue Gong, Chenxi Zhang, Siqi Zhao, Xutong Yang, Yanling He
Summary: Platelet-rich plasma is considered a novel therapy for treating FPHL, showing positive efficacy in hair density. The study summarized different PRP preparation methods and treatment regimes, and analyzed its efficacy in FPHL treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Mai H. El-Naggar, Fatma M. Abdel Bar, Harsha Choudhary, Monisha Javadi, Kuniyoshi Shimizu, Ajaikumar B. Kunnumakkara, Farid A. Badria
Summary: Synthesized ricinine analogues showed inhibitory activity against oral cancer cells without toxicity to normal cells. Compound 19 was the most active derivative, with 69.22% inhibition of oral cancer cell proliferation. The downregulation of PTP1B and COX-2 by compound 19 was identified as potential targets for oral cancer inhibition.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mohamed H. Ahmed, Hala M. Aldesouki, Farid A. Badria
Summary: The Psidium guajava leaf fractions, quinalizarin and ellagic acid, exhibit strong inhibitory activities against three metabolism-related enzymes, showing multitarget effects with potential therapeutic applications in various metabolic disorders.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mohamed El-Mesery, Axel Seher, Mohamed El-Shafey, Mohamed El-Dosoky, Farid A. Badria
Summary: The study showed that quinoline alkaloids can enhance DOX-induced apoptotic cell death in human cervical and hepatocellular carcinoma cells by inducing apoptosis through the cleavage of Caspase-3 and PARP, and increasing cell fractions in the sub-G0/G1 phase.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Fardous F. El-Senduny, Miram Altouhamy, Gamal Zayed, Choudhary Harsha, Renjitha Jalaja, Sasidhar Balappa Somappa, Mangalam S. Nair, Ajaikumar B. Kunnumakkara, Fahd M. Alsharif, Farid A. Badria
Summary: Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with a need for improved treatments. Research has shown that loading AZD into liposomes can enhance its bioavailability and anticancer activity, potentially serving as a promising approach to improve oral drug delivery systems.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Diaaeldin M. Elimam, Abdullah A. Elgazar, Fardous F. El-Senduny, Ramadan A. El-Domany, Farid A. Badria, Wagdy M. Eldehna
Summary: In this study, piperine-based amides and ureas were developed as potential anticancer agents. Compound 8q showed the most potent anti-proliferative activity against triple negative breast cancer cells, possibly through targeting VEGFR-2.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Fatma M. Abdel Bar, Mohamed M. Abu Habib, Fardous F. El-Senduny, Farid A. Badria
Summary: The study demonstrated that silver nanoparticles biosynthesized using Psidium guajava and Lawsonia inermis leaf extracts exhibited potent cytotoxicity against colon cancer cells and breast cancer cells, with higher cytotoxicity observed for nanoparticles derived from Lawsonia inermis. Additionally, the nanoparticles showed moderate antioxidant activity compared to their respective extracts.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Mohammad Azam, Ved Prakash Verma, Assem Barakat, Matti Haukka, Luis R. Domingo, Abdullah A. Elgazar, Amira Mira, Farid A. Badria
Summary: In this study, a new series of spirooxindole analogs were synthesized and evaluated for their neuroprotective properties through the inhibition of acetylcholine esterase enzyme. Three compounds showed the strongest inhibitory activity, with one compound exhibiting the most potent inhibition. The incorporation of NO2 group and N-methylglycine were found to play a crucial role in the activity of these compounds.
Article
Chemistry, Multidisciplinary
Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Mohammad Azam, Ved Prakash Verma, Assem Barakat, Matti Haukka, Abdullah A. Elgazar, Amira Mira, Farid A. Badria
Summary: Twenty-five new hits of spirooxindole analogs engrafted with indole and pyrazole scaffolds were designed and constructed through a [3+2]-cycloaddition reaction. Compounds 8i and 8y showed the strongest acetylcholine esterase inhibition and were further studied with molecular docking for their interaction with the active site of hAChE.
Article
Pharmacology & Pharmacy
Eman A. Mazyed, Farid A. Badria, Mai H. ElNaggar, Soha M. El-Masry, Sally A. Helmy
Summary: The aim of this study was to develop a novel ultra-deformable cyclodextrin-functionalized transethoniosomes (CD-TENs) as a promising delivery system for 6-gingerol (6-G). The results showed that CD-TENs can improve the solubility and stability of 6-G and be a potential drug delivery carrier.
Article
Chemistry, Applied
Eman M. Elattar, Mona Shaban, Hassan-Elrady A. Saad, Farid A. Badria, Amal A. Galala
Summary: In this study, vanillin was used as a starting material to synthesize five new triazole derivatives and one known derivative through click chemistry. The newly synthesized compounds showed enhanced antimicrobial and antifungal activities, while compounds 1 and 2 exhibited high antiquorum-sensing activity. Compounds 4-7 demonstrated selective cytotoxicity against cancer cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Matti Haukka, Marwa M. Abu-Serie, Alexander Domling, Eman A. Mazyed, Farid A. Badria, Fardous F. El-Senduny
Summary: This study investigated the anticancer activity of the compound SP1 and its nanoformulation against breast adenocarcinoma. The results showed that SP1 exhibited strong inhibitory effects on multiple cancer cell lines and induced apoptosis. The use of a nanoformulation improved the selectivity of the compound against cancer cells. In vivo studies on mice confirmed the ability of SP1 to halt the proliferation of breast cancer cells and suppress metastasis.
BIOORGANIC CHEMISTRY
(2022)
Article
Plant Sciences
Rowida M. Omar, Farid A. Badria, Amal A. Galala
Summary: In current drug discovery, there is a growing focus on designing drug molecules that interact with multiple targets simultaneously (exhibiting compound promiscuity). Previous screening research on 54 medicinal plants found that the methanol extract of Phylanthus emblica L. leaves showed promising inhibitory activity against alpha amylase, tyrosinase, and hyaluronidase enzymes. Further fractionation of the extract led to the isolation of two flavone glycosides, with one of them, luteolin-7-O-a-L-rhamnoside, exhibiting strong inhibitory activity against the enzymes. This study suggests that luteolin-7-O-a-L-rhamnoside could be used as a potential promiscuous enzyme inhibitor for the management and treatment of certain chronic diseases.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Chemistry, Multidisciplinary
Eman M. Elattar, Amal A. Galala, Hassan-Elrady A. Saad, Farid A. Badria
Summary: Chemical transformation study is an important tool for new drugs discovery. In this study, new eugenol 1,2,3-triazole derivatives were synthesized via click chemistry using the Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition method. Their inhibitory effects on hyaluronidase enzyme were examined, and one derivative showed enhanced inhibitory effect compared to its parent compound eugenol.
Article
Biochemistry & Molecular Biology
Reem A. ElGamal, Amal A. Galala, Maged S. Abdel-Kader, Farid A. Badria, Amal F. Soliman
Summary: The biotransformation of vulgarin, a sesquiterpene lactone obtained from Artemisia judaica, was performed by Aspergillus niger to produce three more polar metabolites. The structures of these metabolites were determined using NMR spectroscopy and HRESIMS. The anti-inflammatory activity of vulgarin and its metabolites was evaluated, and vulgarin showed preferential inhibitory activity against COX-2, while its metabolite (3a) exhibited selective inhibition against COX-1.
Retraction
Obstetrics & Gynecology
T. Marzouk, R. Barakat, A. Ragab, F. Badria, A. Badawy
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)