Article
Chemistry, Multidisciplinary
Xiaoyue Ma, Lei Kuang, Ying Yin, Lin Tang, Yu Zhang, Qin Fan, Bingyi Wang, Zhufeng Dong, Wei Wang, Tieying Yin, Yazhou Wang
Summary: This study developed an activated mature dendritic cell membrane-coated nanoplatform, aDCM@PLGA/RAPA, which can cross the blood-brain barrier and improve the immune micro-environment, effectively inhibiting glioma growth with great potential for antiglioma immunotherapy.
Article
Chemistry, Multidisciplinary
Siyu Chi, Li Zhang, Hemei Cheng, Yaran Chang, Yaoyao Zhao, Xiayan Wang, Zhihong Liu
Summary: Glioma is a deadly disease with high fatality rate and short survival time. However, the blood brain barrier and non-targeted drug distribution pose challenges for effective treatment. To address this issue, a hybrid cell membrane camouflage strategy was proposed to construct therapeutic nanocomposites with BBB permeability and glioma targeting ability. The resulting biomimetic therapeutic agent, HMGINPs, demonstrated excellent biocompatibility and superior efficacy in treating early-stage glioma.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biotechnology & Applied Microbiology
Jie Li, Huamin Zeng, Yu You, Rongrong Wang, Tiantian Tan, Weiming Wang, Liyan Yin, Zhaowu Zeng, Yiying Zeng, Tian Xie
Summary: The study demonstrated that the active-targeting biomimetic liposome, Tf-ELE/CTX@BLIP, is highly stable and exhibits significant homologous targeting and immune evasion. In vivo studies showed that treatment with Tf-ELE/CTX@BLIP led to increased survival time and decreased tumor volume in mice, making it a promising nanoplatform for drug delivery to gliomas.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Engineering, Environmental
Ying Yin, Wei Tang, Xiaoyue Ma, Lin Tang, Yu Zhang, Meng Yang, Fangfang Hu, Guanglin Li, Yazhou Wang
Summary: This study presents an effective approach for treating malignant glioma based on neutrophil-macrophage hybrid membrane coating nanotechnology. The biomimetic nanoparticle can overcome the blood-brain barrier and target glioma, showing high therapeutic efficacy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Assaf Zinger, Sirena Soriano, Gherardo Baudo, Enrica De Rosa, Francesca Taraballi, Sonia Villapol
Summary: The study developed leukocyte-based biomimetic nanoparticles for direct treatment of traumatic brain injury, achieving selective targeting of the damaged brain and accumulation in peripheral organs. The therapeutic approach showed potential efficacy in reducing brain damage.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Yong-Jiang Li, Jun-Yong Wu, Jihua Liu, Xiaohan Qiu, Wenjie Xu, Tiantian Tang, Da-Xiong Xiang
Summary: Biomimetic drug delivery systems based on blood cells for brain drug delivery have rapidly grown, showcasing their engineering feasibility and versatile delivery ability, but face translational challenges in the future.
Review
Chemistry, Multidisciplinary
Jun Liao, Li Fan, Yi Li, Qing-Qiang Xu, Li-Yan Xiong, Shan-Shan Zhang, Ji-Hao Liu, Zhi-Cheng Xiao, Chuan Zhang, Jian Yang, Zhe-Sheng Chen, Kai Xiao, Ting-Fang Wang, Ying Lu
Summary: In recent years, brain diseases have become a serious threat to human health due to their high incidence and mortality rates. The main challenge in treating these diseases is delivering drugs efficiently to the brain. Biomimetic nanodelivery systems (BNDSs) have been developed to overcome the obstacles posed by the brain's unique structure and the blood-brain barrier. The enhanced drug-carrying ability and lesion-targeting selectivity of BNDSs offer new opportunities for safe and effective therapies. This review summarizes brain-targeting nanotherapies, particularly those with biomimetic nano-assistance, and discusses the prospects and challenges of their clinical application.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Yu-Chen Lo, Wen-Jen Lin
Summary: The study utilized a peptide-conjugated nano-delivery system to enhance penetration into tumor cells by overcoming the blood brain barrier. NPs conjugated with T7 peptide showed higher accumulation in the brain and lower biodistribution in nontarget tissues. The benefit of T7 peptide as a targeting ligand for NPs across the BBB was elucidated in this study.
Article
Multidisciplinary Sciences
Jianglong Kong, Rui Zou, Ga-Lai Law, Yi Wang
Summary: In this study, a NIR PL nanoparticle TRZD was synthesized, which exhibited excellent rechargeable NIR PL in vivo and could be used for long-term autofluorescence-free imaging. TRZD could inhibit the tumor growth of glioma models and provide a promising multifunctional nanoparticle for theranostics of brain diseases.
Article
Chemistry, Multidisciplinary
Yang-Bao Miao, Kuan-Hung Chen, Chiung-Tong Chen, Fwu-Long Mi, Yu-Jung Lin, Yen Chang, Chi-Shiun Chiang, Jui-To Wang, Kun-Ju Lin, Hsing-Wen Sung
Summary: An oral prodrug delivery system has been developed to target gliomas by overcoming the intestinal epithelial barrier and the blood-brain barrier. The prodrug specifically targets intestinal M cells, crosses the barriers, and releases the active drug at the tumor site for improved therapeutic efficacy.
ADVANCED MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Xin Xin, Wei Liu, Zhe-Ao Zhang, Ying Han, Ling-Ling Qi, Ying-Ying Zhang, Xin-Tong Zhang, Hong-Xia Duan, Li-Qing Chen, Ming-Ji Jin, Qi-Ming Wang, Zhong-Gao Gao, Wei Huang
Summary: RVG15-Lipo is a promising brain-targeted nanovehicle with tumor-specificity, showing efficient BBB penetration and enhanced drug permeability and selectivity at tumor sites. In vivo experiments demonstrated that PTX-CHO-RVG15-Lipo significantly inhibited glioma growth, improving the survival rate of mice.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Shaobo Shan, Junge Chen, Yu Sun, Yongchao Wang, Bozhang Xia, Hong Tan, Changcun Pan, Guocan Gu, Jie Zhong, Guangchao Qing, Yuxuan Zhang, Jinjin Wang, Yufei Wang, Yi Wang, Pengcheng Zuo, Cheng Xu, Fangzhou Li, Weisheng Guo, Lijun Xu, Meiwan Chen, Yubo Fan, Liwei Zhang, Xing-Jie Liang
Summary: This study developed a nano drug delivery system based on functionalized macrophage exosomes, which could efficiently deliver drugs and gene therapeutics for targeted therapy of DIPG tumor cells, resulting in prolonged survival of patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tom Finck, Jens Gempt, Claus Zimmer, Jan S. Kirschke, Nico Sollmann
Summary: The study suggests that CE BB imaging can significantly improve the delineation of therapy-naive HGGs compared to traditional TFE imaging, indicating a potential supplementary role for CE BB sequences in MRI protocols for brain tumors.
EUROPEAN RADIOLOGY
(2021)
Article
Engineering, Biomedical
Jun Wang, Wei Tang, Meng Yang, Ying Yin, Hui Li, Fangfang Hu, Lin Tang, Xiaoyue Ma, Yu Zhang, Yazhou Wang
Summary: NEs-Exos system exhibits neutrophil-like chemotactic function and BBB penetration capability, efficiently suppressing tumor growth and prolonging survival time in a glioma mouse model.
Article
Nanoscience & Nanotechnology
Juan Cen, Xiaoying Dai, Han Zhao, Xiaohan Li, Xiaojiao Hu, Jing Wu, Shaofeng Duan
Summary: In this study, a dual targeting liposomal delivery vector loaded with doxorubicin (DOX) was developed to treat glioma. The liposomes demonstrated high drug encapsulation rate and drug-loading capacity, and showed satisfactory biocompatibility and stability. Experimental results showed that the liposomes could effectively cross the BBB and target gliomas, and the mitochondria targeting of SS31 enhances cell uptake. The liposomes also showed good therapeutic effect on nude mice with glioma in situ.
ACS APPLIED MATERIALS & INTERFACES
(2023)