Article
Immunology
Silvana Valdebenito, Simon Bessis, Djillali Annane, Geoffroy Lorin de la Grandmaison, Elisabeth Cramer-Borde, Brendan Prideaux, Eliseo A. Eugenin, Morgane Bomsel
Summary: SARS-CoV-2-induced lung damage in COVID-19 patients is highly heterogeneous, manifesting as hemorrhage, immune infiltration, or a combination of both, leading to loss of alveolar wall integrity, lung tissue detachment, and fibrosis. Pathological analysis revealed a strong immune response in COVID-19 cases, with significant B cell infiltration and poor T cell infiltration, indicating a compromised immune cellular response in these patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Hassen Kared, Andrew D. Redd, Evan M. Bloch, Tania S. Bonny, Hermi Sumatoh, Faris Kairi, Daniel Carbajo, Brian Abel, Evan W. Newell, Maria P. Bettinotti, Sarah E. Benner, Eshan U. Patel, Kirsten Littlefield, Oliver Laeyendecker, Shmuel Shoham, David Sullivan, Arturo Casadevall, Andrew Pekosz, Alessandra Nardin, Michael Fehlings, Aaron A. R. Tobian, Thomas C. Quinn
Summary: Characterization of T cell responses in convalescent individuals from SARS-CoV-2 infection revealed unique phenotypes and a coordinated immune response, with specific CD8(+) T cell responses directed against various epitopes from the virus proteome. The differentiation of T cells into stem cell and transitional memory subsets may be crucial for developing lasting protection against the virus.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Infectious Diseases
Michael Gurevich, Rina Zilkha-Falb, Polina Sonis, David Magalashvili, Shay Menascu, Shlomo Flechter, Mark Dolev, Mathilda Mandel, Anat Achiron
Summary: This study demonstrates the durability of adaptive cellular immunity for at least 7 months after SARS-CoV-2 infection, suggesting long-lasting protection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Immunology
Min-Seok Rha, Eui-Cheol Shin
Summary: CD8(+) T cells play a protective role in the immune response against COVID-19, exhibiting activated phenotypes in patients despite a decrease in absolute numbers. The upregulation of inhibitory immune checkpoint receptors and expression of exhaustion-associated gene signatures in these cells have been reported, but the true exhaustion of CD8(+) T cells during COVID-19 remains controversial.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Weiming Xia, Mingfei Li, Ying Wang, Lewis E. Kazis, Kim Berlo, Noureddine Melikechi, Gregory R. Chiklis
Summary: This study analyzed longitudinal blood samples from 943 convalescent COVID-19 patients over seven months to quantify antibody decay rates, finding that patients with higher initial antibody levels showed a significantly faster reduction rate, and most donors' antibodies were detected above threshold for only four months post-infection.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Anuradha Rajamanickam, Pavan Kumar Nathella, Aishwarya Venkataraman, Bindu Dasan, Sulochana Putlibai, Shaik Fayaz Ahamed, Nandhini Selvaraj, Kalaimaran Sadasivam, Balasubramanian Sundaram, Thomas B. Nutman, Subash Babu
Summary: This cross-sectional study suggests that multisystem inflammatory syndrome in children (MIS-C) and COVID-19 in children are associated with the hyperactivation of the complement system. The findings of this study may provide new avenues for research and treatment of MIS-C and COVID-19.
Article
Immunology
Chang Kyung Kang, Minji Kim, Jisu Hong, Gwanghun Kim, Soojin Lee, Euijin Chang, Pyoeng Gyun Choe, Nam Joong Kim, Ik Soo Kim, Jun-Young Seo, Daesub Song, Dong-Sup Lee, Hyun Mu Shin, Yong-Woo Kim, Chang-Han Lee, Wan Beom Park, Hang-Rae Kim, Myoung-don Oh
Summary: A year after COVID-19, immune responses varied among patients with asymptomatic, mild, and severe illness, with parameters such as phagocytic capacity of antibodies and memory B-cell responses strongly associated with disease severity. These findings could inform tailored vaccination strategies post-natural infection based on COVID-19 severity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sara De Biasi, Marco Mattioli, Marianna Meschiari, Domenico Lo Tartaro, Annamaria Paolini, Rebecca Borella, Anita Neroni, Lucia Fidanza, Stefano Busani, Massimo Girardis, Francesca Coppi, Anna Vittoria Mattioli, Giovanni Guaraldi, Cristina Mussini, Andrea Cossarizza, Lara Gibellini
Summary: There is growing evidence indicating that hyperinflammation, dysregulated T and B cell response, and cytokine storm contribute significantly to the immunopathogenesis of severe COVID-19. IL-6, a pro-inflammatory cytokine, is elevated during SARS-CoV-2 infection. Tocilizumab, an IL-6R blocker, has been shown to improve survival in critically ill patients. However, its effectiveness is still limited in some patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Nizar A. Khamjan, Mohtashim Lohani, Mohammad Faheem Khan, Saif Khan, Abdullah Algaissi
Summary: Currently available COVID vaccines are effective in reducing mortality and severity but do not prevent transmission or reinfection. A broad-spectrum vaccine is needed to address the evolving SARS-CoV-2 virus and prevailing strains, which can reduce both transmission and reinfection rates. This study used bioinformatics techniques to design multiple epitope vaccines using conserved regions of the virus and showed promising results in computer simulations.
Article
Oncology
Laura Mansi, Laurie Spehner, Etienne Daguindau, Kevin Bouiller, Hamadi Almotlak, Ulrich Stein, Adeline Bouard, Stefano Kim, Elodie Klajer, Marine Jary, Guillaume Meynard, Angelique Vienot, Charlee Nardin, Fernando Bazan, Quentin Lepiller, Virginie Westeel, Olivier Adotevi, Christophe Borg, Marie Kroemer
Summary: Cancer patients exposed to SARS-CoV-2 produced a high rate of specific antibodies, but lacked T-cell responses against the virus, indicating a deficiency in protective T-cell immunity. However, their immune memory against common viruses remained intact.
EUROPEAN JOURNAL OF CANCER
(2021)
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Article
Multidisciplinary Sciences
Daniel M. Altmann, Catherine J. Reynolds, George Joy, Ashley D. Otter, Joseph M. Gibbons, Corinna Pade, Leo Swadling, Mala K. Maini, Tim Brooks, Amanda Semper, Aine Mcknight, Mahdad Noursadeghi, Charlotte Manisty, Thomas A. Treibel, James C. Moon, Rosemary J. Boyton
Summary: This study analyzes the immune response in healthcare workers with mild or asymptomatic SARS-CoV-2 infection and compares it to those with Long Covid. The results show no significant differences in immune responses between the two groups up to 18 weeks post-infection and 1 year after vaccination, suggesting that immune response variations are unlikely to be a contributing factor to Long Covid development.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Masayuki Miyasaka
Summary: Understanding the protective immunity against SARS-CoV-2 is crucial for gaining insights into COVID-19 pathophysiology and developing novel treatment strategies. More research is needed to determine the known and unknown aspects of the immune response during COVID-19, and further investigation is required to ascertain whether natural infections can lead to herd immunity.
INTERNATIONAL IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Felipe V. C. Machado, Claus F. Vogelmeier, Rudolf A. Joerres, Henrik Watz, Robert Bals, Tobias Welte, Martijn A. Spruit, Peter Alter, Frits M. E. Franssen
Summary: The impact of low FFMI on exercise capacity, health-related quality of life (HRQL), and systemic inflammation differs among patients with COPD stratified by body weight.
Article
Cell Biology
Caroline Diener, Martin Hart, Tim Kehl, Anouck Becker-Dorison, Tanja Taenzer, David Schub, Lena Krammes, Martina Sester, Andreas Keller, Marcus Unger, Barbara Walch-Rueckheim, Hans-Peter Lenhof, Eckart Meese
Summary: Parkinson's disease is a complex and multifactorial disease in which dysregulated T cells play a central role in the pathogenesis. This study used time-resolved RNA expression analysis of peripheral CD4+ T cells to uncover changes in cellular signaling during different stages of Parkinson's disease. The findings revealed altered expression of specific genes and highlighted the involvement of the IL-17 pathway, including an increased prevalence of Th17 cells and a specific subtype of IL-17 producing gamma delta-T cells.
CELL DEATH DISCOVERY
(2023)
Article
Medicine, General & Internal
Yohhei Hamada, Rishi K. Gupta, Matteo Quartagno, Abbie Izzard, Carlos Acuna-Villaorduna, Neus Altet, Roland Diel, Jose Dominguez, Sian Floyd, Amita Gupta, Helena Huerga, Edward C. Jones-Lopez, Aarti Kinikar, Christoph Lange, Frank van Leth, Qiao Liu, Wei Lu, Peng Lu, Irene Latorre Rueda, Leonardo Martinez, Stanley Kimbung Mbandi, Laura Munoz, Elisabeth Sanchez Padilla, Mandar Paradkar, Thomas Scriba, Martina Sester, Kwame Shanaube, Surendra K. Sharma, Rosa Sloot, Giovanni Sotgiu, Kannan Thiruvengadam, Richa Vashishtha, Ibrahim Abubakar, Molebogeng X. Rangaka
Summary: This study compares the performance of tuberculin skin tests (TST) and interferon-gamma release assays (IGRA) in predicting incident active tuberculosis (TB) and finds that IGRA has a higher predictive performance in low TB incidence countries, although this difference is influenced by a single study. Both tests perform poorly in high TB incidence countries.
Article
Engineering, Biomedical
Sebastian Mang, Lena Reichert, Ralf M. Muellenbach, Jonathan Riesner, Christopher Lotz, Alexander Supady, Haitham Mutlak, Robert Bals, Torben M. Rixecker, Andre P. Becker, Maximilian Leitner, Carsten Zeiner, Guy Danziger, Patrick Meybohm, Frederik Seiler, Philipp M. Lepper
Summary: This study compared the outcomes of COVID-19 patients transported by mobile ECMO teams with those cannulated in experienced ECMO centers. The results showed that COVID-19 patients transported by mobile ECMO teams had no excess risk compared to those receiving VV-ECMO in experienced ECMO centers.
Editorial Material
Infectious Diseases
Saskia Bronder, Martina Sester
LANCET INFECTIOUS DISEASES
(2023)
Letter
Immunology
Stephen Zewinger, Jochen Reiser, Vera Jankowski, Dalia Alansary, Eunsil Hahm, Sarah Triem, Mira Klug, Stefan J. Schunk, David Schmit, Rafael Kramann, Christina Koerbel, Emmanuel Ampofo, Matthias W. Laschke, Simina-Ramona Selejan, Anna Paschen, Tobias Herter, Susanne Gaul, Guenther Silbernagel, Martina Sester, Urban Sester, Gunter Assmann, Robert Bals, Gerhard Kostner, Willi Jahnen-Dechent, Michael D. Menger, Lucia Rohrer, Winfried Maerz, Michael Boehm, Joachim Jankowski, Manfred Kopf, Eicke Latz, Barbara A. Niemeyer, Danilo Fliser, Ulrich Laufs, Thimoteus Speer
Article
Immunology
Barbara C. Gaertner, Verena Klemis, Tina Schmidt, Martina Sester, Tim Meyer
Summary: PCR testing of football players and staff in German Bundesliga and Bundesliga 2 revealed 98 positive cases, with 11 individuals showing transient low viral load positive results. These individuals were asymptomatic and did not develop long COVID. Only one out of the 11 individuals developed specific immune response, while the others did not. This finding suggests cautious interpretation and retesting of positive PCR results before initiating treatment or infection control measures.
Article
Medicine, General & Internal
Laura Ziegler, Verena Klemis, Tina Schmidt, Sophie Schneitler, Christina Baum, Jurgen Neumann, Soeren L. Becker, Barbara C. Gaertner, Urban Sester, Martina Sester
Summary: Both ipsilateral and contralateral vaccination against COVID-19 induce immune responses, but ipsilateral vaccination results in a stronger immune response, providing better protection against infection and severe disease.
Article
Respiratory System
Erin L. Tomaszewski, Mark J. Atkinson, Christer Janson, Niklas Karlsson, Barry Make, David Price, Helen K. Reddel, Claus F. Vogelmeier, Hana Mullerova, Paul W. Jones
Summary: The Chronic Airways Assessment Test (CAAT), a questionnaire adapted for patients with asthma and/or COPD, has been shown to be consistent and accurate in measuring overall health status in these patients.
RESPIRATORY RESEARCH
(2023)
Article
Biochemical Research Methods
Sanjay K. Srikakulam, Sebastian Keller, Fawaz Dabbaghie, Robert Bals, Olga Kalinina
Summary: MetaProFi is a Bloom filter-based tool that allows rapid searches in large sequence datasets. It is the first tool that can build indexes of amino acid sequences and query them with both amino acid and nucleotide sequences, bringing sequence comparison to the biologically relevant protein level.
Article
Respiratory System
Kathrin Kahnert, Rudolf A. Joerres, Hans-Ulrich Kauczor, Peter Alter, Franziska C. Trudzinski, Felix Herth, Bertram Jobst, Oliver Weinheimer, Sebastian Nauck, Pontus Mertsch, Diego Kauffmann-Guerrero, Juergen Behr, Robert Bals, Henrik Watz, Klaus F. Rabe, Tobias Welte, Claus F. Vogelmeier, Juergen Biederer
Summary: This study aimed to evaluate the association of Pi10, a measure of standardized airway wall thickness on CT, with exacerbations, mortality, and response to triple therapy in patients with COPD. The results showed that Pi10 was associated with COPD severity, comorbidities, lung function, respiratory therapy, and mortality, and it had some predictive ability.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Letter
Medicine, General & Internal
Laura Ziegler, Verena Klemis, Tina Schmidt, Sophie Schneitler, Christina Baum, Juergen Neumann, Soeren L. Becker, Barbara C. Gaertner, Urban Sester, Martina Sester
Letter
Urology & Nephrology
Hristos Karakizlis, Vipul Agarwal, Mostafa Aly, Kevin Strecker, Benjamin Csala, Isla Esso, Jiangping Chen, Christian Nahrgang, Martin Wolter, Heiko Slanina, Christian G. Schuettler, Soenke Jessen, Claudio Ronco, Werner Seeger, Rolf Weimer, Martina Sester, Horst-Walter Birk, Faeq Husain-Syed
JOURNAL OF NEPHROLOGY
(2023)