GZ17-6.02 and Doxorubicin Interact to Kill Sarcoma Cells via Autophagy and Death Receptor Signaling

Cholesterol derivatives induce dephosphorylation of the histone deacetylases Rpd3/HDAC1 to upregulate autophagy

(2020) Wenmei Wu et al.   Autophagy

Combination therapy with Olaratumab/doxorubicin in advanced or metastatic soft tissue sarcoma -a single-Centre experience

(2020) Jana Käthe Striefler et al.   BMC CANCER

GZ17‐6.02 initiates DNA damage causing autophagosome‐dependent HDAC degradation resulting in enhanced anti‐PD1 checkpoint inhibitory antibody efficacy

(2020) Laurence Booth et al.   JOURNAL OF CELLULAR PHYSIOLOGY

(Curcumin+sildenafil) enhances the efficacy of 5FU and anti‐PD1 therapies in vivo

(2020) Paul Dent et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Super-enhancers: novel target for pancreatic ductal adenocarcinoma

(2019) Chandrayee Ghosh et al.   Oncotarget

Basic Knowledge in Soft Tissue Sarcoma

(2019) Kévin Bourcier et al.   CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY

A pilot study of first-line olaratumab, doxorubicin and ifosfamide in patients with metastatic soft tissue sarcoma

(2019) Olga Vornicova et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The landscape of tyrosine kinase inhibitors in sarcomas: looking beyond pazopanib

(2019) Christopher P Wilding et al.   Expert Review of Anticancer Therapy

Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds

(2018) Vikalp Vishwakarma et al.   Scientific Reports

Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species

(2017) Jane L. Roberts et al.   Oncotarget

HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo

(2017) Laurence Booth et al.   Oncotarget

The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo

(2017) Laurence Booth et al.   Oncotarget

AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

(2016) Antero Salminen et al.   CELLULAR SIGNALLING

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

(2016) Laurence Booth et al.   Oncotarget

The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling

(2016) Laurence Booth et al.   Oncotarget

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Pazopanib and HDAC inhibitors interact to kill sarcoma cells

(2014) Seyedmehrad Tavallai et al.   CANCER BIOLOGY & THERAPY

The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells

(2009) Yonggang Ma et al.   PHYTOTHERAPY RESEARCH

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

(2008) S. L. McGee et al.   DIABETES