Co-expressing LRP6 With Anti-CD19 CAR-T Cells for Improved Therapeutic Effect Against B-ALL

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

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Wnt3a Neutralization Enhances T-cell Responses through Indirect Mechanisms and Restrains Tumor Growth

(2018) Ilenia Pacella et al.   Cancer Immunology Research

Tisagenlecleucel for the treatment of B-cell acute lymphoblastic leukemia

(2018) Allison Barz Leahy et al.   Expert Review of Anticancer Therapy

The Role of WNT Signaling in Mature T Cells: T Cell Factor Is Coming Home

(2018) Jorg van Loosdregt et al.   JOURNAL OF IMMUNOLOGY

FDA Approval of Tisagenlecleucel

(2017) Peter B. Bach et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Durable Molecular Remissions in Chronic Lymphocytic Leukemia Treated With CD19-Specific Chimeric Antigen Receptor–Modified T Cells After Failure of Ibrutinib

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Axicabtagene ciloleucel, a first-in-class CAR T cell therapy for aggressive NHL

(2017) Zachary J. Roberts et al.   LEUKEMIA & LYMPHOMA

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

(2017) Terry J Fry et al.   NATURE MEDICINE

Chimeric antigen receptor T-cell therapies for lymphoma

(2017) Jennifer N. Brudno et al.   Nature Reviews Clinical Oncology

Immunotherapy: Tisagenlecleucel — the first approved CAR-T-cell therapy: implications for payers and policy makers

(2017) Vinay Prasad   Nature Reviews Clinical Oncology

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

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TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

(2017) Yinmeng Yang et al.   Science Translational Medicine

Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies

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Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

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T-Cell Therapy Using Interleukin-21–Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persistence and Durable Tumor Regression

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Wnt signaling in cancer

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Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells

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IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity

(2015) Guoliang Cui et al.   CELL

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors

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Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

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T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

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Wnt/ -Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy

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Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

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