Article
Oncology
Yuan-ke Liang, Ze-kun Deng, Mu-tong Chen, Si-qi Qiu, Ying-sheng Xiao, Yu-zhu Qi, Qin Xie, Zheng-hao Wang, Shi-cheng Jia, De Zeng, Hao-yu Lin
Summary: The study revealed that in breast cancer, the expression of CXCL9 is significantly higher compared to normal tissue and is associated with better survival outcomes in patients with ER-negative tumors. Additionally, CXCL9 is correlated with immune cell infiltration and immune-related biomarkers including CTL4, GZMB, LAG3, PDCD1, and HAVCR2.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Eugenia Fernandez, Luis Ubillos, Nabila Elgul, Maria Florencia Festari, Daniel Mazal, Otto Pritsch, Isabel Alonso, Eduardo Osinaga, Nora Berois
Summary: Research on the molecular mechanisms of breast cancer has led to the discovery of biomarkers like GalNAc-T13, which is associated with cancer aggressiveness and may serve as a novel biomarker. High expression of GalNAc-T13 is linked to worse patient survival rates, highlighting its potential prognostic significance in breast cancer diagnosis.
Article
Reproductive Biology
Rui Gu, Siyi Tan, Yuping Xu, Donghui Pan, Ce Wang, Min Zhao, Jiajun Wang, Liwei Wu, Shaojie Zhao, Feng Wang, Min Yang
Summary: A radiomics model was developed to identify the status of CXCL9 in ovarian cancer and evaluate its prognostic significance. CXCL9 mRNA levels and other genes involved in T-cell infiltration were found to be significantly associated with overall survival in ovarian cancer patients. The radiomic model based on CT scans can predict CXCL9 and patients with a high radiomic score have better overall survival.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Lin Wang, Ge Cao, Wei Li, Xiao-Wen Chen, Shi-Shuang Xiong, Ya-Nan Mu, Jin-Fang Jiang, Lan Yang, De-Rui Zhang, Yu-Wen Cao
Summary: This study found that the expression of Notch3 and DLL4 is closely associated with the malignancy and prognosis of breast cancer. Overexpression of Notch3 is an independent risk factor for poor prognosis in breast cancer patients.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Oncology
Min Hui Park, Jung Eun Choi, Jae-Ryong Kim, Young Kyung Bae
Summary: This study investigated the immunohistochemical expression of the senescence-associated secretory phenotype (SASP) in invasive breast cancer tissues and found that SASP positivity is related to tumor microenvironments and clinicopathological characteristics of breast cancer. The prognostic significance of SASP depends on the molecular subtype of breast cancer patients.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Oncology
Neslihan Cabioglu, Aysel Bayram, Selman Emiroglu, Semen Onder, Huseyin Karatay, Gizem Oner, Mustafa Tukenmez, Mahmut Muslumanoglu, Abdullah Igci, Adnan Aydiner, Pinar Saip, Ekrem Yavuz, Vahit Ozmen
Summary: This study investigates the expression of new immune checkpoint receptors CD155 and CD73 in patients with residual triple-negative breast cancer after neoadjuvant chemotherapy. The results show that high expression of CD155 is associated with a poor chemotherapy response and prognosis. The coexpression of CD155 and CD73 results in a worse outcome than either marker alone, highlighting the need for further investigation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ai Sato, Kiyoshi Takagi, Ayano Yoshimura, Wakana Tsukamoto, Mio Yamaguchi-Tanaka, Yasuhiro Miki, Akiko Ebata, Minoru Miyashita, Takashi Suzuki
Summary: This study explores the clinical significance of KLK12 in breast cancer. The results show that KLK12 is strongly associated with low-grade malignancy and has favorable prognostic effects. Knockdown of KLK12 enhances proliferation and migration of breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Khloud A. Elsharawy, Maryam Althobiti, Omar J. Mohammed, Abrar I. Aljohani, Michael S. Toss, Andrew R. Green, Emad A. Rakha
Summary: NOP10 is a key factor in ribosome biogenesis and telomere maintenance, and its high expression is significantly associated with aggressive features in breast cancer, especially in the triple-negative breast cancer subtype. High NOP10 protein expression is an independent predictor of poor outcome, shorter survival, and higher risks of death and distant metastasis in chemotherapy-treated patients. This suggests that NOP10 may serve as a potential prognostic biomarker and predictive indicator for chemotherapy resistance in breast cancer.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Ke-Yun Zhu, Yao Tian, Ying-Xi Li, Qing-Xiang Meng, Jie Ge, Xu-Chen Cao, Ti Zhang, Yue Yu
Summary: KLF2 and KLF15 act as tumor suppressors in breast cancer and have potential as biomarkers for prognostic prediction in breast cancer patients.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Sin-Hye Park, Tung Hoang, Jeongseon Kim
Summary: This study examines the relationship between dietary factors and breast cancer prognosis among breast cancer survivors through systematic review and meta-analysis. It finds that unhealthy dietary patterns such as beer and saturated fat intake may worsen breast cancer prognosis, while supplementation of most vitamins is beneficial. The study suggests that developing dietary guidelines based on these findings could improve the prognosis for breast cancer survivors.
Article
Oncology
Hanfang Jiang, Ruyan Zhang, Xiaoran Liu, Ran Ran, Jiayang Zhang, Yaxin Liu, Xinyu Gui, Yifei Chen, Kun Li, Bin Shao, Ying Yan, Xu Liang, Guohong Song, Lijun Di, Huiping Li
Summary: Bilateral breast cancer (BBC) is a rare subtype of breast cancer that affects the Chinese population. A study comparing synchronous bilateral breast cancer (sBBC) and metachronous bilateral breast cancer (mBBC) at an academic cancer center in China found that sBBC is associated with a higher prevalence of family history of breast cancer and poorer prognosis than mBBC. In addition, patients with mBBC were diagnosed at an earlier tumor stage compared to those with sBBC.
Article
Oncology
Young-Il Kim, Robert Luke Pecha, Tara Keihanian, Michael Mercado, S. Valeria Pena-Munoz, Kailash Lang, George Van Buren, Sadhna Dhingra, Mohamed O. Othman
Summary: The expression of MUC1 is closely associated with aggressive pathological features of gastric cancer and can serve as a prognostic marker in US gastric cancer patients.
Article
Oncology
Hong-Bin Li, Jian-Li Wang, Xiao-Dong Jin, Lei Zhao, Hui-Li Ye, Yan-Bei Kuang, Yong Ma, Xiang-Yan Jiang, Ze-Yuan Yu
Summary: The study revealed that the expression levels of S100A family members were higher in PDAC tissues compared to normal pancreatic tissues, and their expressions were negatively correlated with patient survival, indicating their potential as prognostic biomarkers for PDAC patients.
Article
Cell Biology
Hongxi Chen, Lei Zhou, Juanni Li, Kuan Hu
Summary: This study found abnormal expression of ALKBH members in breast cancer and their association with tumor stage and subclasses. Higher alteration rates of ALKBH family were observed in breast cancer and several cancer-associated signal pathways were related to ALKBH family. Infiltration of immune cells was strongly related to ALKBHs. Furthermore, ALKBH7 was correlated with worse prognosis in breast cancer patients.
Article
Cell Biology
Hongxi Chen, Lei Zhou, Juanni Li, Kuan Hu
Summary: This study discovered abnormal expression of ALKBH gene family in breast cancer, which is associated with tumor stage and subclasses. ALKBH family is closely related to several cancer-related signaling pathways and infiltration of immune cells. Additionally, ALKBH7 is strongly correlated with clinical characteristics and prognosis of breast cancer patients.
Article
Medicine, Research & Experimental
Yuxiang Lin, Jie Zhang, Yan Li, Wenhui Guo, Lili Chen, Minyan Chen, Xiaobin Chen, Wenzhe Zhang, Xuan Jin, Meichen Jiang, Han Xiao, Chuan Wang, Chuangui Song, Fangmeng Fu
Summary: CTPS1 is upregulated in TNBC and is associated with poor prognosis in patients. Silencing CTPS1 inhibits TNBC cell proliferation, migration, and invasion. YBX1 can bind to the promoter of CTPS1 and promote its transcription. Furthermore, YBX1 expression is positively correlated with CTPS1 in TNBC tissues.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)