When the Search for Stemness Genes Meets the Skin Substitute Bioengineering Field: KLF4 Transcription Factor under the Light

YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity

(2020) Yao Yuan et al.   Nature Communications

Gènes stemness et bioingénierie des greffons cutanés

(2020) Nicolas O. Fortunel et al.   M S-MEDECINE SCIENCES

Induced pluripotent stem cell (iPSC) line from an epidermolysis bullosa simplex patient heterozygous for keratin 5 E475G mutation and with the Dowling Meara phenotype

(2019) Nikola Kolundzic et al.   Stem Cell Research

KLF4 inhibition promotes the expansion of keratinocyte precursors from adult human skin and of embryonic-stem-cell-derived keratinocytes

(2019) Nicolas O. Fortunel et al.   Nature Biomedical Engineering

Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling

(2018) Chengkang Zhang et al.   Cell Reports

Regeneration of the entire human epidermis using transgenic stem cells

(2017) Tobias Hirsch et al.   NATURE

A LncRNA-MAF:MAFB Transcription Factor Network Regulates Epidermal Differentiation

(2015) Vanessa Lopez-Pajares et al.   DEVELOPMENTAL CELL

Bioengineering a Human Plasma-Based Epidermal Substitute With Efficient Grafting Capacity and High Content in Clonogenic Cells

(2015) Maia M. Alexaline et al.   Stem Cells Translational Medicine

ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes

(2014) Lisa D. Boxer et al.   GENES & DEVELOPMENT

ACTL6a Enforces the Epidermal Progenitor State by Suppressing SWI/SNF-Dependent Induction of KLF4

(2013) Xiaomin Bao et al.   Cell Stem Cell

ZNF750 Is a p63 Target Gene that Induces KLF4 to Drive Terminal Epidermal Differentiation

(2012) George L. Sen et al.   DEVELOPMENTAL CELL

Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion

(2011) F Yu et al.   ONCOGENE

Generation of keratinocytes from normal and recessive dystrophic epidermolysis bullosa-induced pluripotent stem cells

(2011) M. Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploration of the functional hierarchy of the basal layer of human epidermis at the single-cell level using parallel clonal microcultures of keratinocytes

(2010) Nicolas O. Fortunel et al.   EXPERIMENTAL DERMATOLOGY

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

(2010) Na-Yu Chia et al.   NATURE

Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells

(2010) Christian Lange et al.   NEUROSCIENCE LETTERS

Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study

(2009) Hind Guenou et al.   LANCET