Review
Public, Environmental & Occupational Health
Ling-Hui Zeng, Musaddique Hussain, Shahzada Khurram Syed, Malik Saadullah, Qurratulain Jamil, Ali M. Alqahtani, Taha Alqahtani, Nadia Akram, Imran Ahmad Khan, Sajida Parveen, Tehreem Fayyaz, Mobeen Fatima, Saira Shaukat, Najia Shabbir, Mehwish Fatima, Aisha Kanwal, Muhammad Qasim Barkat, Ximei Wu
Summary: Low- and middle-income countries bear a disproportionately high burden of chronic respiratory diseases, which are closely linked to poverty, infectious diseases, and other non-communicable diseases. The prevention and control of NCDs are identified as an urgent development issue by the WHO, crucial for achieving sustainable development goals by 2030. In this context, finding solutions for the prevention, identification, and management of CRDs in LMICs is crucial for achieving universal health coverage.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Respiratory System
Pei Yee Tiew, Jayanth Kumar Narayana, Marilynn Swee Li Quek, Yan Ying Ang, Fanny Wai San Ko, Mau Ern Poh, Tavleen Kaur Jaggi, Huiying Xu, Kai Xian Thng, Mariko Siyue Koh, Augustine Tee, David Shu Cheong Hui, John Arputhan Abisheganaden, Krasimira Tsaneva-Atanasova, Fook Tim Chew, Sanjay H. Chotirmall
Summary: This study found that sensitization to Aspergillus fungi is associated with exacerbations in patients with chronic obstructive pulmonary disease (COPD). By assessing 35 fungal allergens, two distinct sensitization subgroups were identified: one characterized by Aspergillus sensitization, which had more severe symptoms and worse lung function; and another characterized by Cladosporium sensitization, which exhibited more prominent symptoms. In addition, sensitization to recombinant Aspergillus allergens was found to be associated with worse COPD outcomes.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Pediatrics
Kodippilikande W. D. A. Anuradha, Paththini K. Ganganath Gunathilaka, Vithanage P. Wickramasinghe
Summary: Incorporating HS nebulization into ACT is an effective strategy to improve dynamic lung volumes and morbidity in children with non-CF bronchiectasis.
PEDIATRIC PULMONOLOGY
(2021)
Article
Respiratory System
Maria Budai-Szucs, Szilvia Berko, Anita Kovacs, Pongsiri Jaikumpun, Rita Ambrus, Adrien Halasz, Piroska Szabo-Revesz, Erzsebet Csanyi, Akos Zsembery
Summary: This study investigated the effect of hypertonic salt solutions on CF sputum viscoelasticity in vitro, using a rheometer to measure the rheological properties of samples. The results showed significant changes in gel strength when different additives were used at varying ratios, with NaHCO3 having the most pronounced effect. The study highlights the importance of individual evaluation of sputum samples based on their rheological properties for effective treatment.
BMC PULMONARY MEDICINE
(2021)
Article
Respiratory System
Wang Chun Kwok, James Chung Man Ho, Terence Chi Chun Tam, Mary Sau Man Ip, David Chi Leung Lam
Summary: The study revealed that patients with longer duration of non-cystic fibrosis bronchiectasis and those on proton pump inhibitors (PPIs) are more likely to have Pseudomonas aeruginosa colonization, leading to more extensive lung involvement and higher risks of exacerbation requiring hospitalization.
RESPIRATORY RESEARCH
(2021)
Article
Medicine, General & Internal
Almudena Gonzalez-Montaos, Cristina Ramos-Hernandez, Irene Lojo-Rodriguez, Marta Nunez-Fernandez, Alberto Fernandez-Villar
Summary: Nebulized hypertonic saline improves the quality of life and reduces exacerbations in patients with cystic fibrosis. However, it is unknown if it has the same benefits in other hypersecretory pathologies.
Article
Respiratory System
Camilla Margaroli, Hamed Horati, Luke W. Garratt, Vincent D. Giacalone, Craig Schofield, A. Susanne Dittrich, Tim Rosenow, Brian S. Dobosh, Hong S. Lim, Dario L. Frey, Mieke Veltman, George L. Silva, Milton R. Brown, Carsten Schultz, Harm A. W. M. Tiddens, Sarath Ranganathan, Joshua D. Chandler, Peng Qiu, Limin Peng, Bob J. Scholte, Marcus A. Mall, Anthony Kicic, Lokesh Guglani, Stephen M. Stick, Hettie M. Janssens, Rabindra Tirouvanziam
Summary: This study found that upregulation of PD-1 is associated with airway macrophage exhaustion, neutrophil takeover, infection, and structural damage in children with cystic fibrosis.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Medicine, General & Internal
Seung Jun Lee, Jong Hwan Jeong, Manbong Heo, Sunmi Ju, Jung-Wan Yoo, Yi Yeong Jeong, Jong Deog Lee
Summary: In patients with non-CF bronchiectasis, serum fibrinogen level is significantly associated with the severity and exacerbation of the disease, while adiponectin and angiopoietin-2 are not. High fibrinogen levels and Pseudomonas colonization are independent risk factors for future exacerbation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Chun-Yu Lin, Hung-Yu Huang, Meng-Heng Hsieh, Yueh-Fu Fang, Yu-Lun Lo, Shu-Min Lin, Yu-Tung Huang, Chih-Hsin Yeh, Chun-Hua Wang, Horng-Chyuan Lin
Summary: This study investigated the impact of nontuberculous mycobacteria (NTM) in non-cystic fibrosis bronchiectasis in Taiwan. The results showed that NTM were associated with frequent exacerbations and mortality in non-cystic fibrosis bronchiectasis patients, especially when coexisting with Pseudomonas aeruginosa and fungus. Additionally, the presence of single or multiple NTM isolates was an independent risk factor for mortality.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Gizem Guenes Guensel, Thomas M. Conlon, Aicha Jeridi, Rinho Kim, Zeynep Ertuez, Niklas J. Lang, Meshal Ansari, Mariia Novikova, Dongsheng Jiang, Maximilian Strunz, Mariia Gaianova, Christine Hollauer, Christina Gabriel, Ilias Angelidis, Sebastian Doll, Jeanine C. Pestoni, Stephanie L. Edelmann, Marlene Sophia Kohlhepp, Adrien Guillot, Kevin Bassler, Hannelore P. Van Eeckhoutte, Oezgecan Kayalar, Nur Konyalilar, Tamara Kanashova, Sophie Rodius, Carolina Ballester-Lopez, Carlos M. Genes Robles, Natalia Smirnova, Markus Rehberg, Charu Agarwal, Ioanna Krikki, Benoit Piavaux, Stijn E. Verleden, Bart Vanaudenaerde, Melanie Koenigshoff, Gunnar Dittmar, Ken R. Bracke, Joachim L. Schultze, Henrik Watz, Oliver Eickelberg, Tobias Stoeger, Gerald Burgstaller, Frank Tacke, Vigo Heissmeyer, Yuval Rinkevich, Hasan Bayram, Herbert B. Schiller, Marcus Conrad, Robert Schneider, Ali Oender Yildirim
Summary: This study demonstrates the role of PRMT7 in regulating the recruitment and pro-inflammatory phenotype of macrophages in chronic obstructive pulmonary disease (COPD). Reduced expression of PRMT7 is associated with decreased recruitment of monocytes to the site of injury and less severe symptoms in mouse models.
NATURE COMMUNICATIONS
(2022)
Article
Pediatrics
Alejandro Teper, Carlos Kofman, Jessica Alchundia Moreira, Teresa Kohler, Facundo Garcia Bournissen
Summary: This study evaluated bronchodilator responses to albuterol nebulized with 3% hypertonic saline solution in asthmatic children, compared to nebulization with normal saline solution. The results showed that albuterol produced a greater bronchodilator response when nebulized with 3% hypertonic saline solution than normal saline solution in asthmatic children with mild or moderate bronchial obstruction.
PEDIATRIC PULMONOLOGY
(2021)
Article
Medicine, General & Internal
Chun-Yu Lin, Meng-heng Hsieh, Yueh-Fu Fang, Chien-Wei Peng, Jia-Shiuan Ju, Yu-Lun Lo, Shu-Min Lin, Horng-Chyuan Lin
Summary: The BSI, FACED score, and DSP showed similar predictive power for mortality in non-CF bronchiectasis patients. However, DSP did not correlate with acute exacerbations and emergency department visits.
ANNALS OF MEDICINE
(2021)
Article
Medicine, General & Internal
Frederic Schlemmer, Agnes Hamzaoui, Sonia Zebachi, Aurelie Le Thuaut, Gilles Mangiapan, Isabelle Monnet, Amel Boudjema, Laurence Jabot, Bruno Housset, Sylvie Bastuji-Garin, Laurence Bassinet, Bernard Maitre
Summary: This study aimed to develop a clinical score to identify adult patients with bronchiectasis who are at higher risk of having cystic fibrosis or primary ciliary dyskinesia. Through diagnostic work-ups and logistic-regression analyses, specific factors associated with CF/PCD diagnosis were identified and a score was validated in a second cohort. The results showed that age at symptom onset, chronic ENT symptoms, digestive symptoms, and specific microbial isolates from sputum were significantly associated with CF or PCD diagnosis, with the developed score demonstrating good performance in identifying high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Anna Annunziata, Ilaria Ferrarotti, Antonietta Coppola, Maurizia Lanza, Pasquale Imitazione, Sara Spinelli, Pierpaolo Di Micco, Giuseppe Fiorentino
Summary: The study evaluated the incidence of alpha-1 antitrypsin deficiency in patients with chronic pulmonary disease in Naples, Italy. Results showed 36 patients with intermediate AAT levels deficiency, with rare variants and compound heterozygosity. The study supports early diagnosis and treatment for patients with chronic pulmonary disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Salony Verma, Joseph L. Mathew, Pallab Ray
Summary: Cystic fibrosis (CF) bronchiectasis and non-CF bronchiectasis may have differences in microbial communities and antibiotic susceptibility patterns, studying these differences could help improve the management of both conditions.
SYSTEMATIC REVIEWS
(2021)
Article
Respiratory System
Miguel A. Martinez-Garcia, Manuel Sanchez-de-la-Torre, David P. White, Ali Azarbarzin
Summary: Conventional measures of OSA severity, such as AHI and ODI, have limitations in capturing the severity of OSA and its physiological consequences. The sleep apnea-specific hypoxic burden (HB), which measures the sum of individual areas under the oxygen desaturation curve, shows promise in identifying high-risk individuals with OSA. HB captures the depth and duration of OSA-related hypoxemia, providing important disease characterizing features not captured by conventional metrics.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Review
Allergy
Wei-jie Guan, Grace Oscullo, Meng-zhang He, Dan-yuan Xu, Jose Daniel Gomez-Olivas, Miguel Angel Martinez-Garcia
Summary: Bronchiectasis is a complex and heterogeneous disease with various causes. It is characterized by neutrophilic inflammation but can also involve eosinophilic inflammation. Eosinophilic diseases, such as asthma and allergic bronchopulmonary aspergillosis, may coexist with bronchiectasis. Additionally, some bronchiectasis patients exhibit eosinophilia without identified concomitant diseases, and the role of eosinophils in this condition is not fully understood.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Letter
Critical Care Medicine
Martino F. Pengo, Grace Oscullo, Jose Daniel Gomez-Olivas, Grzegorz Bilo, Gianfranco Parati, Miguel Angel Martinez-Garcia
Article
Critical Care Medicine
Miguel Angel Martinez-Garcia, Raul Mendez, Casilda Olveira, Rosa Giron, Marta Garcia-Clemente, Luis Maiz, Oriol Sibila, Rafael Golpe, Juan Luis Rodriguez-Hermosa, Esther Barreiro, Concepcion Prados, Juan Rodriguez-Lopez, Grace Oscullo, Gonzalo Labarca, David de la Rosa
Summary: This study found a significant U-shaped relationship between BEC and severity and exacerbations in bronchiectasis, which was more prominent in the eosinopenic group. IC treatment only decreased the number and severity of exacerbations in the eosinophilic group.
Review
Medicine, General & Internal
David de la Rosa-Carrillo, Guillermo Suarez-Cuartin, Oriol Sibila, Rafael Golpe, Rosa-Maria Giron, Miguel-angel Martinez-Garcia
Summary: The use of inhaled antibiotics has expanded beyond cystic fibrosis patients to include non-CF bronchiectasis or chronic obstructive pulmonary disease patients. Inhaled antibiotics provide high concentrations at the site of infection, enhancing their effectiveness and allowing for long-term administration. New formulations of inhaled dry powder antibiotics offer advantages such as faster preparation and administration, as well as eliminating the need for cleaning nebulization equipment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Miguel Angel Martinez-Garcia
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Respiratory System
M. Miravitlles, M. A. Martinez-Garcia
Letter
Critical Care Medicine
Miguel Angel Martinez-Garcia, Alvar Agusti
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Allergy
Grace Oscullo, Jose Daniel Gomez-Olivas, Miguel Angel Martinez-Garcia
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Editorial Material
Clinical Neurology
Grace Oscullo, Jose Daniel Gomez-Olivas, Miguel Angel Martinez-Garcia
SLEEP AND BREATHING
(2023)
Editorial Material
Clinical Neurology
Grace Oscullo, Jose Daniel Gomez-Olivas, Miguel Angel Martinez-Garcia
Editorial Material
Medicine, General & Internal
Jose Daniel Gomez-Olivas, Grace Oscullo, Miguel Angel Martinez-Garcia
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jose Daniel Gomez-Olivas, Grace Oscullo, Miguel angel Martinez-Garcia
Summary: Bronchiectasis is a chronic inflammatory disease of the airway caused by various pulmonary and extra-pulmonary diseases. The etiology of bronchiectasis shows significant heterogeneity, with post-infectious and idiopathic bronchiectasis being the most common causes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Grace Oscullo, Jose Daniel Gomez-Olivas, Marina Ingles, Sergio Mompean, Rosalia Martinez-Perez, Guillermo Suarez-Cuartin, David la Rosa-Carrillo, Miguel Angel Martinez-Garcia
Summary: This study assessed the effects of inhaled corticosteroids (ICs) on patients with bronchiectasis-chronic obstructive pulmonary disease overlap syndrome (BCOS) and found that treatment with ICs reduced the frequency and severity of exacerbations without negative impact on other infectious outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Miguel Angel Martinez-Garcia, Rosa Faner, Grace Oscullo, David la Rosa-Carrillo, Juan Jose Soler-Cataluna, Marta Ballester, Alfonso Muriel, Alvar Agusti
Summary: The presence of chronic bronchial infection (CBI) and isolation of Pseudomonas aeruginosa (PA) are independently associated with forced expiratory volume in 1 second (FEV1) decline in patients with COPD.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)