期刊
CELLS
卷 9, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/cells9091967
关键词
cancer; ceramide; gangliosides; immunotherapy; metastasis; phenotype switching; sphingosine 1-phosphate
类别
资金
- INSERM
- Paul Sabatier University
- Fondation Association pour la Recherche sur le Cancer [R18167BB, R19179BB]
- Fondation Toulouse Cancer Sante [R19225BB]
- Institut National du Cancer [R19243BP]
- Transcan-2 Research Program
- ERA-NET Transcan-2 [TRANS201601250]
- Fondation pour la Recherche Medicale
- Societe Francaise de Dermatologie [R18126BB]
Cutaneous melanoma is a deadly skin cancer whose aggressiveness is directly linked to its metastatic potency. Despite remarkable breakthroughs in term of treatments with the emergence of targeted therapy and immunotherapy, the prognosis for metastatic patients remains uncertain mainly because of resistances. Better understanding the mechanisms responsible for melanoma progression is therefore essential to uncover new therapeutic targets. Interestingly, the sphingolipid metabolism is dysregulated in melanoma and is associated with melanoma progression and resistance to treatment. This review summarises the impact of the sphingolipid metabolism on melanoma from the initiation to metastatic dissemination with emphasis on melanoma plasticity, immune responses and resistance to treatments.
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