Article
Microbiology
Jin Geng, Zhuoxiao Sui, Weihao Dou, Yunheng Miao, Tao Wang, Xunfan Wei, Sicong Chen, Zongqi Zhang, Jinhua Xiao, Dawei Huang
Summary: Insects have a long history in traditional medicine. This study explores the potential connection between medicinal values and gut microbes of medicinal insects, revealing an association between medicinal insects and their gut microbes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Qin Jiang, Chunlin Xie, Lingli Chen, Hongli Xiao, Zhilian Xie, Xiaoyan Zhu, Libao Ma, Xianghua Yan
Summary: Daily-phase feeding is a precision feeding method that can improve feed efficiency in pigs. The gut microbiota plays a crucial role in regulating nutrient digestion, absorption, and metabolism. However, the specific key microbes involved in improving feed efficiency during daily-phase feeding strategies remain unclear.
Article
Physiology
Yuuki Shikaya, Masafumi Inaba, Ryosuke Tadokoro, Shota Utsunomiya, Yoshiko Takahashi
Summary: Gut peristalsis is important for transportation, digestion, and absorption of materials. The study developed an optogenetic method to induce artificial waves in the hindgut and found that the coordination between hindgut and cloaca is mediated by signals triggered by peristaltic waves. The optogenetic technology provides a way to study gut peristalsis and explore therapeutic methodologies for peristaltic disorders.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Zoology
Hong-Yu Chen, Chun-Qing Li, Shan-Yuan Chen, Hen Xiao
Summary: This study explores the characteristics of intestinal microbes in cavefish and surface fish, and establishes the relationship between intestinal microbes and habitat microbes. The results show that the structure of intestinal microbes in cavefish and surface fish is more related to habitat type rather than genetic relationships. Differences in gut microbes may enhance the adaptability of these two fish types, involving food intake, nutrient utilization, harmful substance metabolism, etc., further demonstrating the link between food resources, predation patterns, intestinal flora, digestive and absorptive capacity, and feeding habits and preferences with habitat adaptability.
ZOOLOGICAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Renyuan Gao, Chunyan Wu, Yefei Zhu, Cheng Kong, Yin Zhu, Yaohui Gao, Xiaohui Zhang, Rong Yang, Hui Zhong, Xiao Xiong, Chunqiu Chen, Qian Xu, Huanlong Qin
Summary: This study identified microbial and metabolic signatures of colorectal cancer (CRC) with broad population relevance, developed a diagnostic panel for CRC and adenoma, and linked many CRC-associated metabolites with gut microbiome signatures of the disease, providing new insights for exploring CRC-related features.
Article
Microbiology
Anirban Bhar, Laurin Christopher Gierse, Alexander Meene, Haitao Wang, Claudia Karte, Theresa Schwaiger, Charlotte Schroder, Thomas C. Mettenleiter, Tim Urich, Katharina Riedel, Lars Kaderali
Summary: This study utilizes pig gut microbiome data to uncover the roles of microbial families such as Ruminococcaceae, Lachnospiraceae, Spirochaetaceae, and Prevotellaceae in the gut microbiome following Influenza A Virus (IAV) infection. The integration of metaproteomic data also helps identify microbial biomarkers and elucidate their functional roles in protecting the host after IAV infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Howell Leung, Ling Xiong, Yueqiong Ni, Anne Busch, Michael Bauer, Adrian T. Press, Gianni Panagiotou
Summary: Currently, evidence suggests that changes in the gut ecosystem play a role in the development of liver diseases, but the underlying mechanisms are still unclear. In this study, we induced cholestasis in mice and analyzed how alterations in the gut microbiota, caused by impaired bile acid flow, contribute to liver disease progression. Our findings show that the surgery led to significant changes in the microbiome of mice, reducing the production of hepatoprotective compounds and negatively affecting inflammatory cytokines. The decrease in beneficial bacteria and increase in disease-associated bacteria further support the potential therapeutic use of targeting the gut microbiome-bile acids-liver axis for liver diseases.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Medicine, General & Internal
John Walker, Anil Abraham Joy, Larissa J. Vos, Trevor H. Stenson, John R. Mackey, Juan Jovel, Dina Kao, Karen L. Madsen, Gane Ka-Shu Wong
Summary: Chemotherapy in early-stage breast cancer patients is associated with weight gain and changes in body composition, possibly due to alterations in the gut microbiome and the induction of systemic inflammation.
Article
Reproductive Biology
Ritu Sharma, Pankaj Kumar Singh, Suneel Kumar Onteru, Dheer Singh
Summary: The study analyzed the faecal bacterial diversity during three different stages of the estrous cycle in Murrah buffalos, identifying differences in bacterial composition among the stages, with Clostridiales being the most abundant and Bacteroidales present exclusively during estrus. This exploratory microbiome analysis provides insights into the major microbes contributing to perceptible pheromones during estrus.
REPRODUCTIVE BIOLOGY
(2021)
Article
Environmental Sciences
Mercedes Y. Lacourt-Ventura, Brayan Vilanova-Cuevas, Delmarie Rivera-Rodriguez, Raysa Rosario-Acevedo, Christine Miranda, Geronimo Maldonado-Martinez, Johanna Maysonet, Darlene Vargas, Yelitza Ruiz, Robert Hunter-Mellado, Luis A. Cubano, Suranganie Dharmawardhane, Johanna W. Lampe, Abel Baerga-Ortiz, Filipa Godoy-Vitorino, Michelle M. Martinez-Montemayor
Summary: The study found that 25% of Puerto Rican women were classified as equol producers, while the gut microbiota of equol non-producers showed higher diversity. Healthy women with soy and high dairy consumption leading to equol production may result in gut dysbiosis with reduced quantities of healthy bacterial biomarkers, potentially contributing to increased diseased outcomes such as cancer.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Ziqi Wang, Jun Li, Tian Zhang, Tianlan Lu, Han Wang, Meixiang Jia, Jing Liu, Jun Xiong, Dai Zhang, Lifang Wang
Summary: The study identified a significant association between rs363018 in SNAP25 and autism in the Han Chinese population, suggesting that SNAP25 may be a susceptibility gene for autism.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Behavioral Sciences
Stephen Faraone, Tobias Banaschewski, David Coghill, Yi Zheng, Joseph Biederman, Mark A. Bellgrove, Jeffrey H. Newcorn, Martin Gignac, Nouf M. Al Saud, Iris Manor, Luis Augusto Rohde, Li Yang, Samuele Cortese, Doron Almagor, Mark A. Stein, Turki H. Albatti, Haya F. Aljoudi, Mohammed M. J. Alqahtani, Philip Asherson, Lukoye Atwoli, Sven Bolte, Jan K. Buitelaar, Cleo L. Crunelle, David Daley, Soren Dalsgaard, Manfred Doepfner, Stacey Espinet, Michael Fitzgerald, Barbara Franke, Manfred Gerlach, Jan Haavik, Catharina A. Hartman, Cynthia M. Hartung, Stephen P. Hinshaw, Pieter J. Hoekstra, Chris Hollis, Scott H. Kollins, J. J. Sandra Kooij, Jonna Kuntsi, Henrik Larsson, Tingyu Li, Jing Liu, Eugene Merzon, Gregory Mattingly, Paulo Mattos, Suzanne McCarthy, Amori Yee Mikami, Brooke S. G. Molina, Joel T. Nigg, Diane Purper-Ouakil, Olayinka O. Omigbodun, Guilherme Polanczyk, Yehuda Pollak, Alison S. Poulton, Ravi Philip Rajkumar, Andrew Reding, Andreas Reif, Katya Rubia, Julia Rucklidge, Marcel Romanos, J. Antoni Ramos-Quiroga, Arnt Schellekens, Anouk Scheres, Renata Schoeman, Julie B. Schweitzer, Henal Shah, Mary Solanto, Edmund Sonuga-Barke, Cesar Soutullo, Hans-Christoph Steinhausen, James M. Swanson, Anita Thapar, Gail Tripp, Geurt van de Glind, Wim van den Brink, Saskia Van der Oord, Andre Venter, Benedetto Vitiello, Susanne Walitza, Yufeng Wang
Summary: This study curated 208 empirically supported statements about ADHD based on strong evidence. These statements were endorsed by 80 authors from 27 countries and 6 continents, as well as 366 readers who agreed with the contents of the document. The meta-analysis findings provide firm statements about the nature, course, outcome causes, and treatments of ADHD, which can help reduce misconceptions and stigma.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Behavioral Sciences
Qinyi Liu, Qiandong Wang, Xue Li, Xiaoyun Gong, Xuerong Luo, Tingni Yin, Jing Liu, Li Yi
Summary: This study explored the social synchronization of gaze-shift behaviors in response to joint attention in children with ASD, finding that they were able to synchronize their gaze shifts with the female model in the video but at lower levels and with longer latency compared to TD children. These findings offer a new approach to understanding the impairments of social interaction in children with ASD.
Article
Pediatrics
Yajing Sun, Xue Li, Lingzi Xu, Zenghui Ma, Yulu Yang, Tingni Yin, Zilin Gao, Xiaoyun Gong, Lei Li, Qinyi Liu, Xinzhou Tang, Jing Liu
Summary: Adolescents with autism exhibit more health-related risky behaviors compared to neurotypical adolescents, with factors such as anxiety, depression, low self-esteem, low IQ score, low ToM test score, increasing age, and communication disorder identified as risk factors for these behaviors. It is important to pay attention to the emotional state, self-esteem, cognitive function, and communication levels of autistic adolescents with health-related risky behaviors.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2021)
Article
Pediatrics
Xiaoyun Gong, Xue Li, Qiandong Wang, Sio Pan Hoi, Tingni Yin, Liyang Zhao, Fanchao Meng, Xuerong Luo, Jing Liu
Summary: The study found that children with Autism Spectrum Disorder (ASD) pay less attention to social stimuli and prefer nonsocial stimuli. Preference for dynamic social images increased with age in ASD children. There was no association between visual preference and IQ in ASD children, while the severity of social interaction deficits was negatively correlated with preference for dynamic social images.
TRANSLATIONAL PEDIATRICS
(2021)
Article
Psychology, Developmental
Zeng-Hui Ma, Bin Lu, Xue Li, Ting Mei, Yan-Qing Guo, Liu Yang, Hui Wang, Xin-Zhou Tang, Zhao-Zheng Ji, Jing-Ran Liu, Ling-Zi Xu, Yu-Lu Yang, Qing-Jiu Cao, Chao-Gan Yan, Jing Liu
Summary: The study revealed that individuals with autism spectrum disorder exhibit atypical developmental changes in cortico-striatal intrinsic functional connectivity, with connectivity increasing with age, while typically developing individuals show either decreasing or constant connectivity with age. Significant correlations were found between these connectivity changes and specific autistic behaviors.
Article
Psychiatry
Yajing Sun, Zhifei Kong, Yuqing Song, Jing Liu, Xilin Wang
Summary: This study explored the validity and reliability of PHQ-9 for screening depression among patients with neurological disorders and identified factors influencing such patients. The results demonstrated good reliability and validity of PHQ-9 in the Chinese population. Unemployment was found to be a significant risk factor for depression in patients with neurological disorders.
Article
Pediatrics
Hui Wang, Zeng-Hui Ma, Ling-Zi Xu, Liu Yang, Zhao-Zheng Ji, Xin-Zhou Tang, Jing-Ran Liu, Xue Li, Qing-Jiu Cao, Jing Liu
Summary: This study found that individuals with autism spectrum disorder showed different atypical regional gray matter volumetric changes in childhood, adolescence, and adulthood compared to their typically developing peers, highlighting the importance of considering developmental stages of the brain when exploring brain structural atypicalities in autism.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2022)
Article
Multidisciplinary Sciences
Jing He, Yanan Chu, Jing Li, Qingren Meng, Yudong Liu, Jiayang Jin, Yifan Wang, Jian Wang, Bo Huang, Lianjie Shi, Xing Shi, Jiayi Tian, Yunzhi Zhufeng, Ruiling Feng, Wenjing Xiao, Yuzhou Gan, Jianping Guo, Changjun Shao, Yin Su, Fanlei Hu, Xiaolin Sun, Jun Yu, Yu Kang, Zhanguo Li
Summary: This study reveals the imbalance between butyrate-producing and butyrate-consuming species in rheumatoid arthritis patients. It shows that butyrate promotes the production of T-regs and reduces inflammation. Butyrate supplementation can alleviate inflammation by rebalancing immune cells and reducing antibody production.
Article
Psychology, Developmental
Yixiao Hu, Qianhan Xiong, Qiandong Wang, Ci Song, Duo Wang, Haoyang Lu, Wanjun Shi, Ying Han, Jing Liu, Xue Li, Li Yi
Summary: The study explored the early development of social attention in toddlers at high familial risk (HR) for autism spectrum disorder (ASD). It found that HR toddlers showed a decrease in social preference with age, while LR toddlers did not. Both groups exhibited significant social habituation, but HR toddlers habituated slightly slower as age increased, indicating atypical social attention as an early characteristic of toddlers at high familial risk for ASD.
INFANT BEHAVIOR & DEVELOPMENT
(2022)
Article
Clinical Neurology
Yilu Zhao, Li Yang, Gaolang Gong, Qingjiu Cao, Jing Liu
Summary: The study revealed atypical white matter patterns in ASD, ADHD, and other NDDs. Shared microstructural abnormalities in the splenium of the CC were possibly present in ASD and ADHD. No consistent abnormalities were detected in specific learning disorder, motor disorder, or communication disorder.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Genetics & Heredity
Ziqi Wang, Tianlan Lu, Xianjing Li, Miaomiao Jiang, Meixiang Jia, Jing Liu, Dai Zhang, Jun Li, Lifang Wang
Summary: This study investigated the dysregulation of miRNAs in autism in the Han Chinese population. The results showed that 10 miRNAs were significantly differentially expressed in patients with autism, and their targets were related to neurodevelopment, brain functions, and autism.
FRONTIERS IN GENETICS
(2022)
Article
Pediatrics
Ting Mei, Zeng-Hui Ma, Yan-Qing Guo, Bin Lu, Qing-Jiu Cao, Xiao Chen, Liu Yang, Hui Wang, Xin-Zhou Tang, Zhao-Zheng Ji, Jing-Ran Liu, Ling-Zi Xu, Li-Qi Wang, Yu-Lu Yang, Xue Li, Chao-Gan Yan, Jing Liu
Summary: The study found that individuals with autism showed significantly higher ALFF in the dorsal striatum in childhood and remarkably lower ALFF in adulthood, with no significant differences in adolescence. Abnormal ALFF amplitudes were specific to the slow-4 frequency band.
TRANSLATIONAL PEDIATRICS
(2022)
Article
Education & Educational Research
Xinzhou Tang, Zihui Hua, Jiayin Xing, Li Yi, Zhaozheng Ji, Liyang Zhao, Xing Su, Tingni Yin, Ran Wei, Xue Li, Jing Liu
Summary: Verbal fluency tasks can be valuable in predicting diagnoses and symptoms of autism spectrum disorder (ASD) and comorbid ASD and attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. This study found that both ASD and ASD + ADHD groups showed deficits in verbal fluency compared to typically developing individuals. The number of correct word items produced during the task predicted ADHD symptoms and differentiated the ASD and ASD + ADHD groups from the typically developing group. The number of repetitive items and errors differentiated the ASD + ADHD group from the typically developing group and predicted symptoms related to language and social and self-help in ASD.
READING AND WRITING
(2023)
Article
Biotechnology & Applied Microbiology
Zhan Tong, Xin Zhou, Yanan Chu, Tianxu Zhang, Jie Zhang, Xiaoyan Zhao, Zuqun Wang, Rui Ding, Qingren Meng, Jun Yu, Juan Wang, Yu Kang
Summary: Growing evidence suggests altered oral and gut microbiota in autism spectrum disorder (ASD), with specific enrichment of Streptococcal phages in the oral microbiota of ASD subjects. These changes are associated with the severity of ASD clinical manifestations. This study provides new insights into the microbiome-mouth-brain connection and potential therapeutic targets for ASD.
NPJ BIOFILMS AND MICROBIOMES
(2022)