Atomic-scale characterization of mature HIV-1 capsid stabilization by inositol hexakisphosphate (IP6)

TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid

(2020) Alvin Yu et al.   Nature Communications

Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket

(2019) Pierrick Craveur et al.   mBio

GS-CA Compounds: First-In-Class HIV-1 Capsid Inhibitors Covering Multiple Grounds

(2019) Kamal Singh et al.   Frontiers in Microbiology

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

(2019) Stephen R. Yant et al.   NATURE MEDICINE

Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication

(2019) Donna L. Mallery et al.   Cell Reports

Neurotransmitter Funneling Optimizes Glutamate Receptor Kinetics

(2018) Alvin Yu et al.   NEURON

Glutamate and Glycine Binding to the NMDA Receptor

(2018) Alvin Yu et al.   STRUCTURE

Inhibitors of the HIV-1 capsid, a target of opportunity

(2018) Stephanie K. Carnes et al.   Current Opinion in HIV and AIDS

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

(2018) Donna L Mallery et al.   eLife

Inositol phosphates are assembly co-factors for HIV-1

(2018) Robert A. Dick et al.   NATURE

The secrets of the stability of the HIV-1 capsid

(2018) Martin Obr et al.   eLife

IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating

(2018) Robert Dick et al.   Viruses-Basel

Energetics of Glutamate Binding to an Ionotropic Glutamate Receptor

(2017) Alvin Yu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Physical properties of the HIV-1 capsid from all-atom molecular dynamics simulations

(2017) Juan R. Perilla et al.   Nature Communications

HIV-1 Capsid Inhibitors as Antiretroviral Agents

(2016) Suzie Thenin-Houssier et al.   CURRENT HIV RESEARCH

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

(2016) David A. Jacques et al.   NATURE

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

Molecular lock regulates binding of glycine to a primitive NMDA receptor

(2016) Alvin Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure and flexibility of conical HIV-1 capsids determined within intact virions

(2016) Simone Mattei et al.   SCIENCE

Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly

(2016) John M. A. Grime et al.   Nature Communications

HIV-1 assembly, release and maturation

(2015) Eric O. Freed   NATURE REVIEWS MICROBIOLOGY

HIV-1 capsid: the multifaceted key player in HIV-1 infection

(2015) Edward M. Campbell et al.   NATURE REVIEWS MICROBIOLOGY

Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution

(2014) Florian K. M. Schur et al.   NATURE

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

(2014) Akash Bhattacharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Assembly of Retroviruses

(2014) Di L. Bush et al.   Annual Review of Virology

Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes

(2013) Louie Lamorte et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

(2013) Ron O. Dror et al.   NATURE

Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics

(2013) Gongpu Zhao et al.   NATURE

Why nature chose phosphate to modify proteins

(2012) T. Hunter   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Convergence and error estimation in free energy calculations using the weighted histogram analysis method

(2011) Fangqiang Zhu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

How Does a Drug Molecule Find Its Target Binding Site?

(2011) Yibing Shan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic-level modelling of the HIV capsid

(2011) Owen Pornillos et al.   NATURE

Pathway and mechanism of drug binding to G-protein-coupled receptors

(2011) Ron O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disulfide Bond Stabilization of the Hexameric Capsomer of Human Immunodeficiency Virus

(2010) Owen Pornillos et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes

(2009) Kosuke Miyauchi et al.   CELL

CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields

(2009) K. Vanommeslaeghe et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Improved prediction of protein side-chain conformations with SCWRL4

(2009) Georgii G. Krivov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Revisiting the Carboxylic Acid Dimers in Aqueous Solution:  Interplay of Hydrogen Bonding, Hydrophobic Interactions, and Entropy†

(2007) Jianhan Chen et al.   JOURNAL OF PHYSICAL CHEMISTRY B