期刊
ACS SENSORS
卷 5, 期 11, 页码 3420-3431出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.0c01276
关键词
surface-enhanced Raman scattering (SERS) substrates; three-dimensional (3D) hot spots; silver-capped parylene C-coated carbon nanoparticles (Ag-PC@CNPs); SERS-active droplet; nut wizard strategy
资金
- High Technology Research and Development Project of Guangdong [2019B010117001]
- National Natural Science Foundation of China [61771467]
- Youth Innovation Promotion Association, Chinese Academy of Sciences [2018153]
- Innovative Research Group Project of National Science Foundation of China [51821003]
- Fund for Shanxi 1331 Project Key Subject Construction
In this work, a surface-enhanced Raman scattering (SERS)-active droplet with three-dimensional (3D) hot spots prepared from a superhydrophobic SERS substrate, which is inspired by the nut wizard strategy, was developed for ultrasensitive detection in complex liquid environments. The SERS substrate was composed of silver-capped parylene C-coated carbon nanoparticles (Ag-PC@CNPs). Such a SERS substrate was prepared by candle-soot deposition to provide a porous carbon nanoparticle layer followed by deposition of a parylene C film to protect the CNPs and then sputtering of silver nanoparticles. Similar to a nut wizard, a droplet rolling on the Ag-PC@CNP-coated substrate picked up the Ag-PC@CNPs. In this way, a self-concentrated and extremely sensitive SERS-active droplet sensor with 3D hot spots was formed. The sensor did not require precise laser focusing and showed relatively high repeatability and much higher sensitivity than those of a corresponding SERS substrate with two-dimensional hot spots. The sensor also achieved high sensitivity and specificity in complex liquid environments; in addition, bovine serum albumin with a concentration as low as 1 pM can be achieved. Consequently, an extremely simple, flexible, and highly sensitive SERS detection technique applicable to liquid biopsy analysis is anticipated.
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