期刊
CURRENT PHARMACEUTICAL DESIGN
卷 22, 期 8, 页码 1049-1059出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612822666151215095940
关键词
Demyelination; microglia; macrophages; kynurenine pathway; quinolinic acid; kynurenic acid
资金
- National Institutes of Health [R01 GM092993, R01 NS048357, R21 NS073684]
- National Science Foundation (CAREER Award)
- Minnesota Partnership Award for Biotechnology and Medical Genomics
- National Multiple Sclerosis Society [CA1060A]
- Mayo Clinic Center for Clinical and Translational Science (CCaTS)
- Applebaum Foundation
- Hilton Foundation
- Peterson Foundation
- Sanford Foundation
- Moon and Marilyn Park Directorship Fund
- McNeilus family
Accumulating evidence demonstrates involvement of tryptophan metabolites and in particular activation of the kynurenine pathway (KP) in neurocognitive disorders under CNS inflammatory conditions. The KP is involved in several brain-associated disorders including Parkinson's disease, AIDS dementia, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, schizophrenia, and brain tumors. Our review is an attempt to address any relevant association between dysregulation of KP and multiple sclerosis (MS), an inflammatory CNS disorder that ultimately leads to demyelinated brain areas and severe neurological deficits. Modulation of KP is a new topic for the field of MS and warrants further research. The availability of potential KP modulators approved for MS may shed some light into the therapeutic potential of KP antagonists for the treatment of MS patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据