期刊
ANNUAL REVIEW OF VISION SCIENCE, VOL 6, 2020
卷 6, 期 -, 页码 195-213出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-vision-022720-094953
关键词
retinal ganglion cells; axon regeneration; survival; KLF; mTOR; oncomodulin
资金
- National Institutes of Health [P30EY026877, R01-EY026766, R01EY024481, R01EY027881, R01EY026939, R01EY021526]
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Medical Technology Enterprise Consortium
- Gilbert Vision Restoration Initiative
- Research to Prevent Blindness, Inc.
- US Department of Defense Congressionally Directed Medical Research Program [W81XWH16-1-0043]
- National Institute of Child Health and Development Intellectual and Developmental Disabilities Research Centers [HD018655]
- National Eye Institute [P30EY026877, R01-EY026766, R01EY024481, R01EY027881, R01EY026939, R01EY021526]
The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual functional defects observed after traumatic injury, in degenerative diseases such as glaucoma, or in compressive optic neuropathies such as from optic glioma. By using optic nerve crush injury models, recent studies have revealed the cellular and molecular logic behind the regenerative failure of injured RGC axons in adult mammals and suggested several strategies with translational potential. This review summarizes these findings and discusses challenges for developing clinically applicable neural repair strategies.
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