Review
Biochemistry & Molecular Biology
Ya Wang, Juanjuan Zhao, Shipeng Chen, Dongmei Li, Jing Yang, Xu Zhao, Ming Qin, Mengmeng Guo, Chao Chen, Zhixu He, Ya Zhou, Lin Xu
Summary: Abnormal regulation and expression of microRNA, especially let-7, are closely related to the aging process and aging-related diseases. Let-7 plays a crucial role in development and is elevated in aging tissues, participating in multiple pathways that regulate aging. Recent studies also suggest that let-7 may be involved in aging by regulating immune function.
Review
Biochemistry & Molecular Biology
Yifan Huang, Ying Li, Wensen Lin, Shuhao Fan, Haorong Chen, Jiaojiao Xia, Jiang Pi, Jun-Fa Xu
Summary: This review provides an overview of the role and characteristics of circular RNAs (circRNAs) in tuberculosis (TB). CircRNAs, as a type of non-coding RNA, play crucial regulatory roles in the development and progression of TB, and have the potential to serve as diagnostic biomarkers and therapeutic targets.
Review
Genetics & Heredity
Chuang Guo, Haibing Lv, Yulong Bai, Meng Guo, Pengfei Li, Shuping Tong, Kuanjun He
Summary: Schizophrenia is a common and severe mental illness that is difficult to diagnose accurately. The correlation between circRNAs and schizophrenia is being explored, and it is suggested that EV circRNAs could be potential biomarkers for diagnosing schizophrenia due to their stability, disease specificity, content richness, and easy detection.
FRONTIERS IN GENETICS
(2023)
Review
Cell Biology
Caterina Miceli, Manuela Leri, Massimo Stefani, Monica Bucciantini
Summary: Autophagy plays a key role in maintaining cellular and organismal homeostasis, providing the necessary energy during critical development stages and nutrient shortage. It is considered a pro-survival mechanism, but its dysregulation is associated with non-apoptotic cell death. Declining autophagy efficiency with age contributes to various pathological conditions, including cancer, cardiomyopathy, diabetes, liver disease, autoimmune diseases, infections, and neurodegeneration. Understanding the relationship between autophagy and age-related pathologies is crucial for proposing disease prevention strategies and potential clinical applications for long-term health promotion.
AGEING RESEARCH REVIEWS
(2023)
Review
Neurosciences
Feng Xiao, Zhi He, Siqi Wang, Jiamei Li, Xiaolan Fan, Taiming Yan, Mingyao Yang, Deying Yang
Summary: This article summarizes the pathological features of neurodegenerative diseases and the regulatory mechanisms of circRNAs in various types of neurodegenerative diseases. It is found that circRNAs mainly influence the pathological process of neurodegenerative diseases by affecting the abnormal deposition of proteins through multiple mechanisms such as acting as microRNA sponges, binding to proteins, and regulating transcription.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Ana R. Rama, Francisco Quinonero, Cristina Mesas, Consolacion Melguizo, Jose Prados
Summary: This study presents a circular RNA-based miRNA capture system for studying the role of miR-21 in lung cancer. The miR-21 circular sponge was found to inhibit the growth, colony formation, and migration of lung cancer cells, indicating the potential of this method as a tool for capturing other miRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Mohammad H. Ghazimoradi, Naeim Karimpour-Fard, Sadegh Babashah
Summary: Early identification of leukemia is crucial for disease management and survival improvement. Approaches based on accurate biomarkers in body fluids provide patients with high sensitivity and specificity for early diagnosis. Non-coding RNAs have shown potential as biomarkers and therapeutic targets in leukemia due to their involvement in crucial oncogenic processes and their presence in body fluids.
Article
Biochemistry & Molecular Biology
Yu Zhang, Ying Zhong, Shaoyu Guo, Yefei Zhu, Jing Guo, Yuanshuai Fu, Mingyou Li
Summary: This study identified a large number of circRNAs in the ovaries and testes of medaka through RNA sequencing, with some circRNAs showing significant differential expression between the testis and ovary. Experimental validation confirmed that a subset of circRNAs can interact with miRNAs and are expressed in reproductive cells.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2021)
Review
Biochemistry & Molecular Biology
Milijana Janjusevic, Alessandra Lucia Fluca, Federico Ferro, Giulia Gagno, Yuri D'Alessandra, Antonio Paolo Beltrami, Gianfranco Sinagra, Aneta Aleksova
Summary: Heart failure is a major cause of morbidity and mortality worldwide, and early identification of asymptomatic patients with underlying cardiac subclinical disease is important for intervention and prevention. New biomarkers such as micro-RNAs show potential for early diagnosis of cardiac dysfunction, but their application in asymptomatic stages remains a challenge.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Yachen Shi, Qingyun Wang, Ruize Song, Yan Kong, Zhijun Zhang
Summary: Non-coding RNAs, such as microRNAs, circular RNAs, and long non-coding RNAs, play important roles in regulating normal biological processes and may be implicated in the pathogenesis of human diseases like depression. Clinical studies have shown that abnormal expression of ncRNAs in depressed patients compared to healthy individuals, with potential for ncRNAs to serve as biomarkers for diagnosis and treatment. Despite uncertainties regarding their precise roles, ncRNAs demonstrate promising clinical value in the management of depression.
Article
Oncology
Jingwei Li, Qiran Zhang, Decheng Jiang, Jun Shao, Weimin Li, Chengdi Wang
Summary: Lung cancer has the highest mortality rate among malignancies worldwide. Circular RNAs (circRNAs), a type of covalently closed molecules, show potential clinical application prospects in lung cancer. This review explains the biogenesis, biological functions, and pathophysiology of circRNAs, and highlights their forefront in the diagnosis, prognosis, and therapy of lung cancer.
Article
Medicine, Research & Experimental
Di Wu, Anliang Xia, Tianlong Fan, Guoqiang Li
Summary: This study identified circRASGRF2 as significantly upregulated in HCC tissues and cell lines, promoting proliferation and migration of liver cancer cells by sponging miR-1224. Mechanistically, circRASGRF2 was found to enhance the expression of focal adhesion kinase (FAK) in HCC. These findings suggest circRASGRF2 as a central component linking circRNAs to HCC progression, making it a potential therapeutic target.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Cell Biology
Eva Prasnikar, Jure Borisek, Andrej Perdih
Summary: As the world's population ages, there is a growing demand for sustainable solutions to address the burden on socio-economic and health systems. This article discusses the role of cellular senescence in age-related diseases, including its formation, characteristics, mechanisms, and therapeutic approaches. It also briefly examines potential delivery systems for therapies and model organisms for studying senescence, highlighting future research opportunities.
AGEING RESEARCH REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Xiaohan Mei, Shi-You Chen
Summary: In eukaryotes, circular RNAs (circRNAs) are produced through back-splicing of precursor mRNAs (pre-mRNAs), resulting in a covalently closed-loop structure. Due to their unconventional circular form, circRNAs exhibit higher stability compared to linear RNAs and play unique roles in cellular regulation. They are widely expressed in eukaryotes and show tissue- and disease-specific expression patterns, including in the cardiovascular system. Further research is needed to understand the characteristics, biogenesis, and functions of circRNAs, as well as their emerging roles in cardiovascular diseases.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Guadalupe Elizabeth Jimenez Gutierrez, Fabiola V. Borbolla Jimenez, Luis G. Munoz, Yessica Sarai Tapia Guerrero, Nadia Mireya Murillo Melo, Jose Melesio Cristobal-Luna, Norberto Leyva Garcia, Joaquin Cordero-Martinez, Jonathan J. Magana
Summary: Polyamines are short molecules with two or three amine groups that play an important role in age-related diseases. This review provides a new perspective on the involvement of polyamines in cellular and molecular processes related to these diseases, suggesting their potential as novel biomarkers for healthier aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
