MDM2-C Functions as an E3 Ubiquitin Ligase

ProtCID: a data resource for structural information on protein interactions

(2020) Qifang Xu et al.   Nature Communications

Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy

(2018) Meaghan Van Alstyne et al.   GENES & DEVELOPMENT

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

(2017) Koji Nomura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

(2017) Koji Nomura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stress-Induced Isoforms of MDM2 and MDM4 Correlate with High-Grade Disease and an Altered Splicing Network in Pediatric Rhabdomyosarcoma

(2015) Aishwarya G. Jacob et al.   NEOPLASIA

New insights into ubiquitin E3 ligase mechanism

(2014) Christopher E Berndsen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stress-Induced Alternative Splice Forms of MDM2 and MDMX Modulate the p53-Pathway in Distinct Ways

(2014) Aishwarya G. Jacob et al.   PLoS One

MDM2’s social network

(2013) R Fåhraeus et al.   ONCOGENE

Endogenous Human MDM2-C Is Highly Expressed in Human Cancers and Functions as a p53-Independent Growth Activator

(2013) Danielle R. Okoro et al.   PLoS One

Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis

(2013) Tongsen Zheng et al.   Nature Communications

Inhibition of p53 DNA Binding Function by the MDM2 Protein Acidic Domain

(2011) Brittany Cross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

(2011) D. Li et al.   MOLECULAR CANCER RESEARCH

The C terminus of p53 binds the N-terminal domain of MDM2

(2010) Masha V Poyurovsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry