Article
Chemistry, Multidisciplinary
Ran Yan, Jie Ren, Jing Wen, Zheng Cao, Di Wu, Meng Qin, Duo Xu, Roxanne Castillo, Feifei Li, Fang Wang, Zhihua Gan, Chaoyong Liu, Ping Wei, Yunfeng Lu
Summary: This study presents an enzyme therapeutic approach based on superoxide dismutase and catalase for alleviating ischemia-reperfusion injury and pathogen-induced liver injury, offering a potential treatment for organ transplantation and other diseases.
ADVANCED MATERIALS
(2022)
Review
Engineering, Biomedical
Tianjiao Zhao, Wei Wu, Lihua Sui, Qiong Huang, Yayun Nan, Jianhua Liu, Kelong Ai
Summary: This article discusses the biology and molecular mechanisms of myocardial ischemia reperfusion injury, and summarizes the application of ROS-based nanoparticles, highlighting the latest advances in nanotechnology research for the treatment of myocardial ischemia reperfusion injury.
BIOACTIVE MATERIALS
(2022)
Article
Immunology
Kristina Ludwig, Evgeny Chichelnitskiy, Jenny F. Kuehne, Bettina Wiegmann, Jasper Iske, Nadine Ledwoch, Fabio Ius, Kerstin Beushausen, Jana Keil, Susanne Iordanidis, Sebastian V. Rojas, Jawad Salman, Ann-Kathrin Knoefel, Axel Haverich, Gregor Warnecke, Christine S. Falk
Summary: This study found that intermediate monocytes are the major producers of IL-10 in heart transplant patients. The count of monocytes and the ratio of intermediate monocytes to classical monocytes significantly increased compared to pre-transplant levels. These monocytes may play an important role in the clinical outcome and long-term survival of heart transplant recipients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Beatrice Lukenaite, Erika Griciune, Bettina Leber, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: Ischemia-reperfusion injury (IRI) is a common problem during solid organ transplantation (SOT), characterized by multifactorial inflammatory responses. Mixed-lineage kinase domain-like pseudokinase (MLKL) and receptor-interacting protein kinase 3 (RIPK3) play crucial roles in necroptosis. Necrosis also triggers sterile inflammation, leading to graft failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Panagiotis Chronopoulos, Caroline Manicam, Jenia Kouchek Zadeh, Panagiotis Laspas, Johanna Charlotte Unkrig, Marie Luise Goebel, Aytan Musayeva, Norbert Pfeiffer, Matthias Oelze, Andreas Daiber, Huige Li, Ning Xia, Adrian Gericke
Summary: This study demonstrates that resveratrol has a protective effect against ischemia-reperfusion injury in the murine retina, reducing the loss of retinal ganglion cells and endothelial dysfunction of retinal blood vessels. This protective effect may be achieved by suppressing upregulation of nitric oxide synthase 2 and alleviating nitro-oxidative stress.
Review
Biochemistry & Molecular Biology
Pasquale Pagliaro, Claudia Penna
Summary: Myocardial ischemia-reperfusion injury (MIRI) is caused by various mechanisms, including ROS production, altered cellular osmolarity, and inflammatory response. Calcium overload, altered oxygen levels, and mitochondrial ROS are also involved, leading to the opening of mPTP. NLRP3 inflammasome priming and activation play a role in these processes and are associated with cell death and endothelial dysfunction. ROS inhibitors and NLRP3 inhibitors have been studied as potential therapeutic agents in ischemic heart disease, but further research is needed to confirm their clinical use.
Review
Chemistry, Multidisciplinary
Zhan Zhang, Rinkoo Dalan, Zhenyu Hu, Jiong-Wei Wang, Nicholas Ws Chew, Kian-Keong Poh, Ru-San Tan, Tuck Wah Soong, Yunlu Dai, Lei Ye, Xiaoyuan Chen
Summary: Ischemic heart disease (IHD) is a leading cause of disability and death worldwide. Reactive oxygen species (ROS) play a key role in the progression of diabetes, hypertension, and hypercholesterolemia, which are independent risk factors for atherosclerosis and the development of IHD. Nanomedicines, as smart and multifunctional nanocarriers, are being extensively studied and explored for their synergistic therapeutic effects.
ADVANCED MATERIALS
(2022)
Article
Medicine, General & Internal
Wojciech Figiel, Grzegorz Niewinski, Michal Grat, Marek Krawczyk, Jan Stypulkowski, Zbigniew Lewandowski, Maciej Krasnodebski, Waldemar Patkowski, Krzysztof Zieniewicz
Summary: Despite the importance of perioperative hyperoxygenation in preventing postoperative infections, this study found that it should not be used for prophylaxis of infections after liver transplantation due to the lack of efficacy.
Article
Chemistry, Multidisciplinary
Liping Wang, Shuwen Qiu, Xi Li, Yabing Zhang, Minfeng Huo, Jianlin Shi
Summary: Ischemic heart disease is a major cause of death worldwide. This study focuses on the synthesis of tannic acid-assembled tetravalent cerium nanocatalysts for the treatment of ischemia/reperfusion injury. The nanocatalysts effectively rescue cardiomyocytes from oxidative stress and reduce myocardial infarct area in a murine model. This research highlights the potential of nanocatalytic metal complexes as a therapeutic approach for ischemic heart diseases.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Jingjing Wang, Yue Liu, Yi Liu, Haiyan Huang, Shubham Roy, Zhiyong Song, Bing Guo
Summary: Myocardial ischemia-reperfusion injury (IRI) is a common cardiovascular disease caused by the restoration of blood flow to the ischemic myocardium. Nanomedicines have shown great potential in the diagnosis and treatment of myocardial IRI due to their advantageous properties. This review focuses on the rational design of nanomedicines for optimal imaging and therapy of myocardial IRI.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Yongjian Ai, Meng-Qi He, Chengxian Wan, Hua Luo, Hongbo Xin, Yitao Wang, Qionglin Liang
Summary: This review summarizes the recent progress in nanoplatform-based reactive oxygen species scavengers for alleviation of ischemia-reperfusion injury. It provides information on the main sites and mechanisms of ischemia-reperfusion injury, as well as the design, fabrication, and administration principles of nanoplatform-based reactive oxygen species scavengers. The application of these scavengers in the treatment of ischemia-reperfusion injury in various organs is also discussed, along with limitations and potential breakthroughs in developing reactive oxygen species scavengers in this field.
ADVANCED THERAPEUTICS
(2022)
Review
Immunology
Jiale Li, Qinbao Peng, Ronghua Yang, Kunsheng Li, Peng Zhu, Yufeng Zhu, Pengyu Zhou, Gabor Szabo, Shaoyi Zheng
Summary: This review discusses the use of machine perfusion and mesenchymal stem cells to improve the quality and outcomes of marginal organs in transplantation. By continuously perfusing the organs to mimic physiological conditions, evaluating pre-transplant organ function, and treating the organs with pharmacological, gene, and stem cell therapy, the quality and adaptability of the organs can be enhanced. Promising preclinical results indicate the potential clinical translation of this innovative strategy to improve the quality of marginal grafts.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shuangyu Lv, Huiyang Liu, Honggang Wang
Summary: Ischemia/reperfusion (I/R) injury is characterized by limited blood supply to organs followed by restoration of blood flow and reoxygenation. The interaction between autophagy and the NLRP3 inflammasome plays a crucial role in I/R injury, but the specific mechanisms are not fully understood and require further research for clarification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
X. Huang, D. He, Z. Pan, G. Luo, J. Deng
Summary: ROS can mediate various physiological functions, but their over-accumulation can lead to premature aging or death, as well as inflammatory conditions. Advances in nanoscience have led to the development of nanomaterials with unique ROS-scavenging abilities, allowing for the emergence of next-generation strategies to ameliorate ROS-related inflammatory conditions. Ongoing studies and clinical applications of nanomedicine based on ROS scavenging stand to benefit from this interdisciplinary field.
MATERIALS TODAY BIO
(2021)
Article
Multidisciplinary Sciences
Wenjun Li, Yuriko Terada, Yulia Y. Tyurina, Vladimir A. Tyurin, Amit Bery, Jason M. Gauthier, Ryuji Higashikubo, Alice Y. Tong, Dequan Zhou, Felix Nunez-Santana, Emilia Lecuona, Adil Hassan, Kohei Hashimoto, Davide Scozzi, Varun Puri, Ruben G. Nava, Alexander S. Krupnick, Kory J. Lavine, Andrew E. Gelman, Mark J. Miller, Valerian E. Kagan, Ankit Bharat, Daniel Kreisel
Summary: Ischemia reperfusion injury is a common pathological condition triggered by the release of endogenous ligands. In this study, the researchers discovered that necroptosis, a nonapoptotic form of cell death, triggers the recruitment of neutrophils in injured lungs. Initially, neutrophils traffic predominantly to subpleural vessels, guided by chemoattractants produced by nonclassical monocytes. The disruption of pulmonary capillaries by neutrophils leads to vascular leakage and impaired graft function. The study also found that TLR4 signaling and NADPH oxidase 4 expression mediate the arrest of neutrophils, preventing their extravasation. The formation of neutrophil extracellular traps in injured lungs can be disrupted with DNase to prevent vascular leakage and improve graft dysfunction. These findings could have important implications for the development of therapeutics to protect lungs from ischemia reperfusion injury.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Environmental
Jiameng Wang, Hao Cheng, Weiyi Chen, Peide Han, Xiaohong Yao, Bin Tang, Wangping Duan, Pengcui Li, Xiaochun Wei, Paul K. Chu, Xiangyu Zhang
Summary: An injectable, self-healing, near-infrared photosensitive antibacterial hydrogel with enhanced antibacterial activity and accelerated wound healing is prepared by utilizing the photodynamic and photothermal antibacterial effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Ceramics
Ren Guo, Congcong Rong, Song Chen, Jianan Zhang, Akiyoshi Osaka, Toshiyuki Ikoma, Xiaona Li, Weiyi Chen
Summary: In this study, chitosan/Fe3O4/TiO2@TiO2 nanowire microspheres with extracellular matrix-like fibrous surface and photothermal antibacterial property were synthesized. The microspheres significantly enhanced the attachment and proliferation of human umbilical vein endothelial cells and exhibited photothermal antibacterial activity due to the presence of nanofibrous surface and Fe3O4 component.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Xinjie Zheng, Yuan Wu, Huali Zuo, Weiyu Chen, Kai Wang
Summary: Lung cancer is a common malignant tumor with high morbidity and mortality rates globally. The rapid development of nanotechnology has provided opportunities and challenges in the diagnosis and treatment of lung cancer. Metal nanoparticles, a widely studied nanostructure, have shown great potential in biomedical applications related to lung cancer, including imaging and cancer-specific biomarker detection. Moreover, metal nanoparticles can enhance therapeutic efficiency through improved drug delivery, radiotherapy, gene silencing, and photo-driven treatment. This article summarizes the recent advancements in the use of metal nanoparticles for lung cancer therapy and diagnosis, and discusses future perspectives for metal-based nanomedicine. It aims to stimulate more research in the development of metal nanoparticles for lung cancer.
Article
Materials Science, Multidisciplinary
Weiyu Chen, Changjun Wu, Liu Ya, Jianhua Wang, Xuping Su
Summary: This paper studied the pre-oxidation products, surface silicon content, hot-dip galvanized layer structure and corrosion resistance of nodular cast iron pre-oxidized by sodium bicarbonate through scanning electron microscopy, energy-dispersive spectrometry, and X-ray diffraction. It was found that the pre-oxidation product was mainly Fe2O3 at 100 degrees C, Fe2O3 and SiO2 at 200 degrees C, and mainly SiO2 at 300 degrees C. The thickness of the alloy layer in the zinc coating of nodular cast iron continuously decreased with increasing pre-oxidation temperature, and the thickness of the alloy layer at 300 degrees C was 43.9% lower than that without pre-oxidation.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Cell Biology
Yu-Ching Wen, Van Thi Ngoc Tram, Wei-Hao Chen, Chien-Hsiu Li, Hsiu-Lien Yeh, Phan Vu Thuy Dung, Kuo-Ching Jiang, Han-Ru Li, Jiaoti Huang, Michael Hsiao, Wei-Yu Chen, Yen-Nien Liu
Summary: Current treatment options for prostate cancer focus on targeting androgen receptor (AR) signaling, but inhibiting AR may promote the development of neuroendocrine prostate cancer (NEPC). Understanding the regulatory mechanisms of AR is crucial for the clinical management of NEPC. This study revealed the tumor-suppressive role of AR and identified its downregulation of CHRM4 expression. CHRM4 overexpression drives neuroendocrine differentiation in prostate cancer cells and is associated with immunosuppressive cytokine responses in the tumor microenvironment (TME). Targeting CHRM4 and evaluating IFNA17 secretion as a prognostic biomarker could be potential therapeutic strategies for NEPC.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Analytical
Fu-Chuan Hsu, Li-Jie Chen, Zong-Rong Liu, Hsiu-An Tsai, Chin-Hao Lin, Wei-Yu Chen, Hwa-Teng Lee, Tsung-Jen Cheng
Summary: The MPB (Micro Particle Bombarding) process is a powerful technology for enhancing the surface quality of tools or molds/dies. It involves bombarding the surface with extremely small particles at high velocity and pressure to improve surface integrity without damaging micro features. Experimental results show that MPB can increase surface hardness by 14% to 66%, provide better surface roughness, and higher compressive residual stress.
Article
Biochemistry & Molecular Biology
Wei -Yu Chen, Phan Vu Thuy Dung, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Han-Ru Li, Zi-Qing Chen, Michael Hsiao, Jiaoti Huang, Yu-Ching Wen, Yen-Nien Liu
Summary: The conventional treatment for prostate cancer is androgen-deprivation therapy (ADT), which inhibits tumor progression driven by androgen receptor (AR) signaling. ADT-induced recurrence of prostate cancer can develop into a neuroendocrine (NE) phenotype with metabolic disturbances and poor prognosis. However, the metabolic pathways that regulate NE differentiation (NED) in prostate cancer are still unclear.
Editorial Material
Oncology
Yiming Xu, Dawei Jiang, Weiyu Chen
FRONTIERS IN ONCOLOGY
(2023)
Article
Biology
An-Sheng Lee, Yen-Ling Sung, Szu-Hua Pan, Kuo-Tzu Sung, Cheng-Huang Su, Shiao-Li Ding, Ying-Jui Lu, Chin-Ling Hsieh, Yun-Fang Chen, Chuan-Chuan Liu, Wei-Yu Chen, Xuan-Ren Chen, Fa-Po Chung, Shih-Wei Wang, Che-Hong Chen, Daria Mochly-Rosen, Chung-Lieh Hung, Hung- Yeh, Shien-Fong Lin
Summary: This study reveals that the East Asian-specific aldehyde dehydrogenase deficiency (ALDH2*2) is associated with the risk of ventricular arrhythmia caused by low-level alcohol consumption. Both human and mouse models demonstrate prolonged QT interval and increased ventricular arrhythmia episodes in individuals carrying ALDH2 variants. This research is important for formulating safe drinking guidelines and developing protective agents for ALDH2 deficient individuals.
COMMUNICATIONS BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zhou Tian, Qitao Hu, Zhouyi Sun, Ning Wang, Huiling He, Zhe Tang, Weiyu Chen
Summary: In this study, an advanced in situ nanovaccine was developed to enhance the efficacy of radiofrequency ablation (RFA) in liver cancer treatment. The nanovaccine activated the immune system, inhibited tumor metastasis and recurrence, and improved the effectiveness of anti-tumor immune therapy.
Review
Biochemical Research Methods
Yang Li, Jun Wang, Weiyu Chen, Haojie Lu, Ying Zhang
Summary: Extracellular vesicles (EVs) are lipid bilayer-enclosed particles released by all types of cells. Glycosylation, as a common post-translational modification, plays a vital role in various biological functions of EVs. However, studies on the glycoconjugates of EVs are limited compared to those on RNAs or proteins. This review highlights the importance of glycopeptide/glycan enrichment and derivatization for analyzing glycosylation via mass spectrometry (MS).
Review
Biotechnology & Applied Microbiology
Yiming Xu, Jessica C. Hsu, Liyun Xu, Weiyu Chen, Weibo Cai, Kai Wang
Summary: Lung cancer is the leading cause of cancer-related deaths worldwide, but the prognosis for many patients remains poor. Nanomedicine-based adjuvant therapies have emerged as promising approaches to enhance conventional treatments and protect against adverse effects. These therapies have been extensively studied in preclinical and clinical cancer treatments to improve therapeutic outcomes and overcome the limitations of traditional therapies.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Dian Luo, Wei-Yu Chen, Wei-Lun Syu, Shun-Wei Liu, Chih-Hao Chang
Summary: By utilizing effective CGL structure, exciplex host in the EML, simplified device architecture, and nanoparticle-based diffusers, highly efficient TOLEDs can be achieved, surpassing the expected external quantum efficiency linearity and significantly increasing the luminance values.
Article
Medicine, General & Internal
Huan Wang, Yueli Shi, Xia Xu, Shumin Xu, Yuting Shi, Weiyu Chen, Kai Wang
Summary: By constructing a 15 lncRNA prognostic prediction model related to NETs, we found that FAM66C gene is highly expressed in lung adenocarcinoma and is associated with poor prognosis. Knockdown of FAM66C significantly inhibited the proliferation and migration ability of tumor cells. This model provides a new theoretical basis for the early diagnosis and treatment of LUAD patients.
ANNALS OF MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Deling Li, Hui Shi, Qingrong Qi, Baisong Chang, Yuanwen Jiang, Kun Qian, Xiudong Guan, Peng Kang, Ning Ma, Yuan Zhang, Zeyu Zhang, Xiaojing Shi, Chunrong Qu, Yilei Wu, Weiyu Chen, Hao Chen, Baowang Li, Liangpeng Chen, Ziyang Li, Shunchang Ma, Lingyun Xu, Yanrong Zhang, Jie Tian, Zhenhua Hu, Wang Jia, Zhen Cheng
Summary: Benzyl Violet 4B (BV-4B) is discovered as a novel solid-state dye in the NIR-II window and can be used for non-invasively monitoring the fate of medical devices in the human body. It can diagnose the rupture of BV-4B-coated silicone catheter and guide fluorescence-guided surgery for arteriovenous malformation with embolization glue.