期刊
CURRENT ORGANIC CHEMISTRY
卷 20, 期 21, 页码 2136-2160出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272820666160216000723
关键词
IEDDA; Diels-Alder; heterocycles; bioorthogonal ligation; tetrazine; cyclooctyne; strained alkenes
资金
- CNRS
- INCa fellowship (ATIP) within the Institut Curie
In this review we chose to concentrate on the bibliography data from 2013 to 2015 (until February), related to the application of the Inverse Electron Demand Diels-Alder (IEDDA) reaction to the synthesis of heterocycles, as building blocks for natural products synthesis. Moreover, the application of the IEDDA reaction to the recently developed bioorthogonal ligations (in 2008), using tetrazines moieties as the diene partners, and engineered alkenes or alkynes as dienophiles, will be detailed. The in vivo applications of the bioorthogonal ligations are particularly amazing and undoubtedly demonstrate the usefulness of this chemistry.
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