Article
Biochemistry & Molecular Biology
Janusz Lipkowski, Anna Bielejewska, Oliver Presly
Summary: Crystalline products of 1R, 4R-camphor vapor diffusion into an aqueous solution of alpha-cyclodextrin were prepared and analyzed by X-ray structure analysis. Two different forms, a dimeric cavity (phase A) and a complex set of monomeric cavities (phase B), were obtained. Both structures contained camphor molecules that were disordered. Additionally, the structures were solvated by mixtures of water and ethanol. The chemical stabilities of the two structures differed significantly, with phase A being relatively stable and phase B reacting rapidly to changes in its chemical environment, leading to cracking of crystals in solution.
CARBOHYDRATE RESEARCH
(2022)
Review
Chemistry, Applied
Antonio Cid-Samamed, Jaruporn Rakmai, Juan Carlos Mejuto, Jesus Simal-Gandara, Gonzalo Astray
Summary: This review discusses the chemical behavior of cyclodextrin complexes with natural ingredients, synthetic drugs, and other related compounds. It provides literature and examples demonstrating the application of cyclodextrins in improving the characteristics of food compounds. Commercial food and supplement products utilizing cyclodextrins are also mentioned to highlight their potential in biotechnological substance development and food product enhancement.
Article
Pharmacology & Pharmacy
Yandra Y. M. Marinho, Eric Aian P. Silva, Jeferson Y. S. Oliveira, Danillo M. Santos, Bruno S. Lima, Diego S. Souza, Fabricio N. Macedo, Anna C. R. S. Santos, Adriano A. S. Araujo, Carla M. L. Vasconcelos, Lucas A. B. O. Santos, Marcus V. A. Batista, Jullyana S. S. Quintans, Lucindo J. Quintans-Junior, Valter J. de Santana-Filho, Andre S. Barreto, Marcio R. V. Santos
Summary: This study prepared and characterized an inclusion complex of D-LIM and HP-beta-CD and evaluated its cardiovascular effects in an animal model of arrhythmia. The results demonstrated that the D-LIM + HP-beta-CD complex significantly reduced arrhythmias, decreased the duration of arrhythmias, and prevented tachycardia.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Justine M. Kalaw, Mizuki Kitagawa, Hajime Shigemitsu, Toshiyuki Kida
Summary: This study successfully fabricated supramolecular microstructures with highly regulated molecular arrangements using a simple precipitation technique with common solvents. The use of 2-Me-α-CD resulted in the formation of vertically aligned hexagonal microrods, providing insights into the design of supramolecular building blocks for controlled self-assembly.
Article
Food Science & Technology
Dan Shen, Xia Chang, Liling Zhou, Dandan Hao, Zhongxiang Fang, Yang Shan, Lvhong Huang, Gaoyang Li
Summary: In this study, an inclusion complex of citral within hydroxypropyl-beta-cyclodextrin was prepared using ultrasound technique. The complex showed improved thermal stability and antifungal properties. Additionally, treatment with the complex effectively extended the shelf life of strawberries.
Article
Chemistry, Multidisciplinary
Xiaozheng Wu, Jiamin Li, Chunmei Hu, Yingying Zheng, Yufei Zhang, Jianping Li, Mengyue Li, Di Xiao, Li Lu, Yuechang Huang, Xingmin Zhang, Chen Li
Summary: In this study, an inclusion complex of ISL with SBE-beta-CD was successfully prepared, improving the water solubility and antioxidant activities of ISL and enhancing its stability in biological environments.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wanrong Song, Xizhao Chen, Chongshan Dai, Degui Lin, Xuelin Pang, Di Zhang, Gang Liu, Yipeng Jin, Jiahao Lin
Summary: This study successfully improved the bioavailability of curcumin by preparing different complexes of the compound, which is significant for its application.
Article
Polymer Science
Hao Li, Ke Li, Weijun Zhen, Dawei Luo, Ling Zhao
Summary: Poly(lactic acid) (PLA)-beta-cyclodextrin (beta-CD) inclusion complexes (PLA-ICs) were synthesized by ultrasonic coprecipitation with beta-CD and PLA, while vermiculite-PLA-ICs (VMT-PLA-ICs) were synthesized with VMT and PLA-ICs by a coupling method. The resulting PLA/VMT-PLA-ICs nanocomposites showed improved mechanical and thermal properties.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Pharmacology & Pharmacy
Jianfei Sun, Hailong Hong, Ning Zhu, Limin Han, Quanling Suo
Summary: The main purpose of this study was to compare the effects of four preparation methods on the TFLX/HP-13-CD inclusion complex. The results showed that the inclusion complex prepared by solvent evaporation method had more reaction sites and higher solubility, making it the most suitable method for preparing TFLX/HP-13-CD inclusion complexes.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Applied
Changyue Deng, Chuan Cao, Yingying Zhang, Jingwei Hu, Yongqiang Gong, Mingming Zheng, Yibin Zhou
Summary: The formation and stabilization mechanisms of inclusion complexes between beta-cyclodextrin and five C10 aroma molecules were investigated using experimental methods and molecular dynamics simulation. The inclusion complexes had a new crystal structure and better thermal stability. The aroma molecules induced conformational changes in the inclusion complexes, with van der Waals interactions being the main driving force for their spontaneous entry into the cavity.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Physical
Ping Han, Yuanyuan Zhong, Ning An, Shiling Lu, Qingling Wang, Juan Dong
Summary: Sesamol, a natural organic phenolic compound, has great potential in food and chemical industries but faces challenges with instability and poor aqueous solubility. In this study, three inclusion complexes were prepared using cyclodextrins as host molecules to enhance sesamol's water-solubility, with HP-beta-CD identified as the optimal host molecule.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Ayumi Nanri, Masaaki Yoshida, Yoshiyuki Ishida, Daisuke Nakata, Keiji Terao, Florencio Arce, Gerard Lee See, Takashi Tanikawa, Yutaka Inoue
Summary: This study investigated the physicochemical properties of ascorbic acid derivatives complexed with CD-MOF-1 using a solvent evaporation method. Results suggested that CD-MOF-1 may be useful in preparing novel drug carriers for ASCP and ASCDP.
Article
Chemistry, Multidisciplinary
Sudeshna Kundu, Kenjirou Higashi, Makoto Takamizawa, Keisuke Ueda, Kunikazu Moribe
Summary: A new sealed-heating condition is reported to prepare the HC form of the drug/(PEG/& gamma;-CD-PPRX) complex. The guest drug in the HC form demonstrated a size-dependent stoichiometric complexation. The encapsulation efficiency of the guest drugs in the HC form complex was governed by the vapor pressure and molecular size.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Andreas Erichsen, Gunther H. J. Peters, Sophie R. Beeren
Summary: Delta-CD, a minor component of a complex mixture of linear and cyclic glucans, can be synthesized in unprecedented yields by employing a unique template in an enzyme-mediated dynamic combinatorial library of cyclodextrins. NMR spectroscopy studies revealed that delta-CD can form pseudorotaxanes with up to three bolaamphiphiles. This research provides a new method for the preparative-scale synthesis of delta-CD.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Thitiya Boonma, Bodee Nutho, Bunleu Sungthong, Ployvadee Sripadung, Thanyada Rungrotmongkol, Nadtanet Nunthaboot
Summary: The atomistic molecular dynamics simulation shows that scandenin tends to form inclusion complexes with different types of cyclodextrin, with some cyclodextrins exhibiting higher inclusivity than others. The calculations indicate that modified cyclodextrins have a stronger binding affinity to scandenin compared to the parent host molecule.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Cardiac & Cardiovascular Systems
Valter Bianchi, Alfonso R. Martiniello, Jan Mangual, Vincenzo Tavoletta, Gianni Pedrizzetti, Giovanni Tonti, Valentina Maria Caso, Pio Caso, Antonio D'Onofrio
Summary: The study showed that SyncAV may improve electrical synchrony and influence LV flow patterns in patients with heart failure compared to conventional CRT with a fixed AVD, with further improvement observed by combining with MPP.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Donatella Diana, Rossella Di Stasi, Sara Garcia-Vinuales, Lucia De Rosa, Carla Isernia, Gaetano Malgieri, Danilo Milardi, Luca D. D'Andrea, Roberto Fattorusso
Summary: Thermal unfolding studies provide a useful tool for understanding the conformational transitions in protein folding, with the key role of disulfide bonds in driving the folding process highlighted in this research.
Article
Medicine, General & Internal
Valentina Maria Caso, Simona Sperlongano, Biagio Liccardo, Emanuele Romeo, Sergio Padula, Fortunato Arenga, Antonello D'Andrea, Pio Caso, Paolo Golino, Gerardo Nigro, Vincenzo Russo
Summary: During the COVID-19 pandemic, adherence to PCSK9 inhibitors decreased among patients at high cardiovascular risk, leading to elevated LDL cholesterol levels, with few patients maintaining within the therapeutic range. Non-adherence to drug therapy was mainly due to drug prescription failure and fear of infection during the pandemic.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sabrina Esposito, Gianluca D'Abrosca, Anna Antolak, Paolo Vincenzo Pedone, Carla Isernia, Gaetano Malgieri
Summary: An unprecedented effort is being made by the global scientific community to tackle COVID-19 and understand the role of zinc finger proteins in the disease. This understanding could lead to important therapeutic developments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Clementina Acconcia, Antonella Paladino, Maria Della Valle, Biancamaria Farina, Annarita Del Gatto, Sonia Di Gaetano, Domenica Capasso, Maria Teresa Gentile, Gaetano Malgieri, Carla Isernia, Michele Saviano, Roberto Fattorusso, Laura Zaccaro, Luigi Russo
Summary: The crucial role of integrin in pathological processes such as tumor progression and metastasis formation has inspired intense efforts to design novel pharmaceutical agents modulating integrin functions in order to provide new tools for potential therapies. Researchers have discovered a chimeric peptide RGDechi that can specifically recognize alpha v beta 3 integrin and have altered or abolished its binding through chemical modifications. By studying the effects of these modifications, a better understanding of the structural and dynamical determinants involved in integrin recognition mechanism can be obtained.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Martina Dragone, Rinaldo Grazioso, Gianluca D'Abrosca, Ilaria Baglivo, Rosa Iacovino, Sabrina Esposito, Antonella Paladino, Paolo Pedone, Luigi Russo, Roberto Fattorusso, Gaetano Malgieri, Carla Isernia
Summary: There is a strict interaction between copper and zinc in cellular processes. The results of copper's interaction with zinc binding proteins have great significance. In this study, the effects of replacing zinc ions with copper ions of different electronic configurations and ionic radii were explored in the prokaryotic zinc finger protein Ros. The replacement did not lead to a functional domain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Davida Mirra, Giuseppe Spaziano, Renata Esposito, Debora Santonocito, Rosanna Filosa, Fiorentina Roviezzo, Gaetano Malgieri, Gianluca D'Abrosca, Pasquale Iovino, Luca Gallelli, Roberto Fattorusso, Carmelo Puglia, Bruno D'Agostino
Summary: This study aimed to improve the bioavailability of N/OFQ by developing solid lipid nanoparticles (SLNs) and tested its therapeutic efficacy for asthma. The results showed that N/OFQ-SLNs had positive effects on the inflammatory process and the mechanical properties of the airways, suggesting potential therapeutic benefits for asthmatic patients.
Article
Chemistry, Multidisciplinary
M. della Valle, G. D'Abrosca, M. T. Gentile, L. Russo, C. Isernia, S. Di Gaetano, R. Avolio, R. Castaldo, G. Gentile, M. Cocca, G. Malgieri, M. E. Errico, R. Fattorusso
Summary: Humans are estimated to consume several grams per week of nanoplastics through exposure to various sources of contamination. However, the effects of these polymeric particles on living systems are still largely unknown. In this study, the interaction of polystyrene nanoplastics (PS-NPs) with ubiquitin is described at an atomic resolution using CD, NMR, and TEM analyses, revealing the formation of a hard protein corona. Additionally, exposure to PS-NPs in human HeLa cells leads to a significant reduction in ubiquitination. These findings suggest that PS-NPs can cause structural effects on ubiquitin, thereby affecting a vital metabolic process for cell viability.
Article
Chemistry, Multidisciplinary
Luigi Russo, Giulia Salzano, Andrea Corvino, Edoardo Bistaffa, Fabio Moda, Luigi Celauro, Gianluca D'Abrosca, Carla Isernia, Danilo Milardi, Gabriele Giachin, Gaetano Malgieri, Giuseppe Legname, Roberto Fattorusso
Summary: This study investigates the mechanism of thermal unfolding of human prion protein and reveals that the transient electrostatic interactions between the N- and C-terminal domains play a key role in regulating the folding process. The study also provides a clear molecular description of the initial phases of prion misfolding using fluorescence fibrillization assays.
Article
Medicine, General & Internal
Vincenzo Russo, Angelo Silverio, Fernando Scudiero, Antonello D'Andrea, Emilio Attena, Gisella Di Palma, Guido Parodi, Valentina Caso, Stefano Albani, Gennaro Galasso, Egidio Imbalzano, Paolo Golino, Marco Di Maio
Summary: This study found that pre-existing atrial fibrillation (AF) is a common comorbidity in COVID-19 patients, accounting for 25% of cases. Even without significant differences in cardiovascular comorbidities or treatments, pre-existing AF was independently associated with an increased risk of developing severe acute respiratory distress syndrome (ARDS) during hospitalization. However, pre-existing AF did not increase the risk of in-hospital mortality.
MEDICINA-LITHUANIA
(2022)
