期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 38, 期 -, 页码 44-52出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2016.05.016
关键词
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资金
- BBSRC [BB/L002817/1, BB/K020013/1]
- Wellcome Trust [104960/Z/14/Z]
- Biotechnology and Biological Sciences Research Council [BB/L002817/1, BB/K020013/1] Funding Source: researchfish
- BBSRC [BB/K020013/1, BB/L002817/1] Funding Source: UKRI
- Wellcome Trust [104960/Z/14/Z] Funding Source: Wellcome Trust
Domains are the functional building blocks of proteins. In this work we discuss how domains can contribute to the evolution of new functions. Domains themselves can evolve through various mechanisms, altering their intrinsic function. Domains can also facilitate functional innovations by combining with other domains to make novel proteins. We discuss the mechanisms by which domain and domain combinations support functional innovations. We highlight interesting examples where changes in domain combination promote changes at the domain level.
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