期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 37, 期 -, 页码 9-13出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2015.11.001
关键词
-
资金
- National Institutes of Health [R01GM080742]
Discrete Molecular Dynamics (DMD) is a physics-based simulation method using discrete energetic potentials rather than traditional continuous potentials, allowing microsecond time scale simulations of biomolecular systems to be performed on personal computers rather than supercomputers or specialized hardware. With the ongoing explosion in processing power even in personal computers, applications of DMD have similarly multiplied. In the past two years, researchers have used DMD to model structures of disease implicated protein folding intermediates, study assembly of protein complexes, predict protein-protein binding conformations, engineer rescue mutations in disease causative protein mutants, design a protein conformational switch to control cell signaling, and describe the behavior of polymeric dispersants for environmental cleanup of oil spills, among other innovative applications.
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