Article
Immunology
Jiawei Li, Juntao Chen, Mingnan Zhang, Chao Zhang, Renyan Wu, Tianying Yang, Yue Qiu, Jingjing Liu, Tongyu Zhu, Yi Zhang, Ruiming Rong
Summary: The study found that mTOR deficiency enhances the immunosuppressive function of monocytic MDSCs and prolongs the survival time of mouse cardiac transplantation, mainly manifested as promoting MDSC differentiation, increasing intracellular autophagy levels, and inhibiting T cell activation and inducing regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Tianju Liu, Francina Gonzalez De Los Santos, Andrew E. Rinke, Chuling Fang, Kevin R. Flaherty, Sem H. Phan
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease without effective therapy. This study investigated the role of myeloid-derived suppressor cells (MDSCs) expressing B7H3 in IPF. The expansion of MDSCs correlated with disease severity in IPF patients. B7H3-mediated MDSCs activated lung fibroblasts and myofibroblast differentiation, and also suppressed T-cell proliferation. Inhibition of MDSC recruitment with anti-B7H3 antibodies reduced inflammation and fibrosis in a mouse model of pulmonary fibrosis. These findings suggest that MDSCs and B7H3 may play a significant role in the progression of IPF and could be potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Malika Davids, Anil Pooran, Liezel Smith, Michele Tomasicchio, Keertan Dheda
Summary: This study found that circulating myeloid-derived suppressor cells (MDSCs) are induced during active TB disease, with higher frequencies in active TB patients compared to those with latent TB infection. These MDSCs can suppress T-cell proliferation and subvert mycobacterial containment, suggesting potential implications for vaccine and immunotherapeutic interventions against TB. Further studies are needed to understand the mechanisms underlying the effects of MDSCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Vipul K. Singh, Arshad Khan, Yitian Xu, Sunny Mai, Licheng Zhang, Abhishek Mishra, Blanca I. Restrepo, Ping-Ying Pan, Shu-Hsia Chen, Chinnaswamy Jagannath
Summary: This study demonstrates that antagonism of LILRB2 can reprogram human MDSCs into M1 macrophages, leading to enhanced killing of Mycobacterium tuberculosis. This finding provides a potential avenue for targeting MDSCs to eradicate Mtb.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yi Ren, Henrik Baecker, Michael Mueller, Arne Kienzle
Summary: The immune system has a significant impact on bone metabolism in various pathological and inflammatory conditions. Myeloid-derived suppressor cells (MDSCs) are a group of cells that can suppress immune responses and mediate bone remodeling. They can both cause bone erosion through differentiation into osteoclasts and alleviate immune reactions. This review discusses the influence of MDSCs on bone metabolism and potential therapeutic targets for improving bone health.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Mary M. Stevenson, Rajesh M. Valanparambil, Mifong Tam
Summary: The article suggests that immune suppression caused by helminth infections may be related to myeloid-derived suppressor cells (MDSC), and the data collected so far support this hypothesis. Future strategies targeting MDSC could enhance immune responses to eliminate adult worms and prevent reinfection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Steven H. Sun, Brooke Benner, Himanshu Savardekar, Gabriella Lapurga, Logan Good, David Abood, Erin Nagle, Megan Duggan, Andrew Stiff, Mallory J. DiVincenzo, Lorena P. Suarez-Kelly, Amanda Campbell, Lianbo Yu, Robert Wesolowski, Harrison Howard, Hiral Shah, Kari Kendra, William E. Carson
Summary: In melanoma patients receiving immune checkpoint inhibitors, MDSC levels increased significantly in some responders, while PMN-MDSC decreased and CD14+CD15+ MDSC increased significantly in PD patients. Changes in MDSC levels may have prognostic value in immune checkpoint inhibitor therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Julian Schwarz, Jessica Ruehle, Kevin Stephan, Stefanie Dietz, Janina Geissert, Ulrich Schoppmeier, Julia S. Frick, Hannes Hudalla, Trim Lajqi, Christian F. Poets, Christian Gille, Natascha Koestlin-Gille
Summary: The newborn's immune system faces the challenge of fighting off infectious agents and tolerating commensals without excessive inflammation. Myeloid-derived suppressor cells (MDSC) play a role in fetal-maternal tolerance and intestinal inflammation regulation in neonates. The role of MDSC in microbiome establishment has not been investigated. In a mouse model, deletion of HIF-1α in myeloid cells resulted in reduced MDSC expansion, altered microbiome composition, and intestinal T-cell homeostasis, suggesting a role of MDSC in inflammation regulation and microbiome establishment during the neonatal period.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Surgery
Yuerong Ren, Xiaonan Dong, Han Zhao, Jianing Feng, Baihua Chen, Yedi Zhou, Yingqian Peng, Liwei Zhang, Qinghua Zhou, Yunping Li, Mengbo Wu, Yan He
Summary: Myeloid-derived suppressor cells (MDSC) play a negative role in immune responses and tumor progression through pro-angiogenic activity and immunosuppressive functions. However, they have been shown to regulate neovascularization post-transplantation. Ex vivo generated MDSC may potentially serve as a valuable agent for inducing anti-angiogenic regulation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Immunology
Germana Grassi, Stefania Notari, Simona Gili, Veronica Bordoni, Rita Casetti, Eleonora Cimini, Eleonora Tartaglia, Davide Mariotti, Chiara Agrati, Alessandra Sacchi
Summary: SARS-CoV-2 is the causative agent of COVID-19, which can lead to severe respiratory distress syndrome. The immune response in COVID-19 patients is impaired, and there is a massive expansion of MDSCs. The early expansion of MDSCs can predict the fatal outcome of the infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Claudia Giannotta, Federica Autino, Massimo Massaia
Summary: Myeloid derived suppressor cells (MDSC) have significant roles in regulating immune homeostasis and immune responses, especially in cancer. MDSC interact with cancer cells in the tumor microenvironment through various mechanisms such as producing soluble factors, expressing inhibitory molecules, rewiring metabolism, and releasing exosomes. The relationship between MDSC and tumor cells leads to immune evasion and cancer growth. In multiple myeloma (MM), MDSC play a major role in creating a tumor-promoting microenvironment. This minireview discusses the interplay between MDSC and MM microenvironment, as well as potential strategies to target MDSC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Utku Horzum, Digdem Yoyen-Ermis, Ekim Z. Taskiran, Kerim Bora Yilmaz, Erhan Hamaloglu, Derya Karakoc, Gunes Esendagli
Summary: In cancer patients, a specific subpopulation of monocytes expressing CD66b was identified in the circulation. These monocytes displayed high phagocytic activity, matrix adhesion, and migration, and provided costimulation for T cell proliferation and IFN-gamma secretion without suppressing T cell responses. They represent a novel myeloid subpopulation which lacks immune regulatory influences and shows enhanced proinflammatory capacities.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Immunology
M. Malavika, S. Sanju, M. R. Poorna, Veeraraghavan Vishnu Priya, Neeraj Sidharthan, Praveen Varma, Ullas Mony
Summary: This review focuses on the role of myeloid derived suppressor cells (MDSCs) in infection, sepsis, and septic shock, and their contribution to lymphopenia and immune suppression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Cell Biology
Jia-Nan Cheng, Yi-Xiao Yuan, Bo Zhu, Qingzhu Jia
Summary: MDSCs play a crucial role in regulating immune responses, promoting tumor progression, and predicting therapeutic outcomes. Targeting MDSCs could potentially improve treatment efficacy in cancer therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yin Celeste Cheuk, Shihao Xu, Dong Zhu, Yongsheng Luo, Tian Chen, Juntao Chen, Jiawei Li, Yi Shi, Yi Zhang, Ruiming Rong
Summary: The supernatant derived from myeloid-derived suppressor cells (MDSCs) inhibits the transforming growth factor beta 1 (TGF-beta 1)-induced myofibroblastic differentiation of mesenchymal stem cells (MSCs) through IL-15. This finding provides a new perspective for the development of treatment strategies for renal fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
