Article
Multidisciplinary Sciences
Julie Livingstone, Yu-Jia Shiah, Takafumi N. Yamaguchi, Lawrence E. Heisler, Vincent Huang, Robert Lesurf, Tsumugi Gebo, Benjamin Carlin, Stefan Eng, Erik Drysdale, Jeffrey Green, Theodorus van der Kwast, Robert G. Bristow, Michael Fraser, Paul C. Boutros
Summary: The study integrates telomere length, genomics, transcriptomics and proteomics in localized prostate cancer, revealing the links between telomere maintenance, disease drivers and clinical outcomes. Shorter tumor telomere lengths are associated with elevated genomic instability and genes involved in cell proliferation and signaling, while longer telomere lengths in non-tumor samples are associated with a lower rate of biochemical relapse.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Alexandros Papachristodoulou, Antonio Rodriguez-Calero, Sukanya Panja, Elizabeth Margolskee, Renu K. Virk, Teresa A. Milner, Luis Pina Martina, Jaime Y. Kim, Matteo Di Bernardo, Alanna B. Williams, Elvis A. Maliza, Joseph M. Caputo, Christopher Haas, Vinson Wang, Guarionex Joel De Castro, Sven Wenske, Hanina Hibshoosh, James M. McKiernan, Michael M. Shen, Mark A. Rubin, Antonina Mitrofanova, Aditya Dutta, Cory Abate-Shen
Summary: NKX3.1 plays a crucial role in suppressing prostate cancer by protecting mitochondrial function under oxidative stress conditions. Its import to mitochondria and regulation of mitochondrial-encoded genes contribute to restoring oxidative phosphorylation and preventing cancer initiation. The expression levels and subcellular localization of NKX3.1 could potentially serve as biomarkers for evaluating cancer risk and clinical outcomes in precision prevention settings.
Article
Oncology
Muzamil Y. Want, Takemasa Tsuji, Prashant K. Singh, James L. Thorne, Junko Matsuzaki, Ellen Karasik, Bryan Gillard, Eduardo Cortes Gomez, Richard C. Koya, Amit Lugade, Kunle Odunsi, Sebastiano Battaglia
Summary: Elevated levels of WHSC1 are positively correlated with an immunosuppressive microenvironment in prostate cancer, according to TCGA data. In vitro studies have shown that inhibition of WHSC1 can restore antigen presentation through epigenetic regulation of gene expression. In vivo studies in immunocompetent mice also demonstrated an increase in CD8(+) T cells in tumors following treatment with a WHSC1 inhibitor, indicating the importance of a fully functional immune system in the antitumor effects of WHSC1 inhibition.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, Research & Experimental
Yangsong He, Yanan Han, A-Hui Fan, Danxiu Li, Boda Wang, Kun Ji, Xin Wang, Xiaodi Zhao, Yuanyuan Lu
Summary: This study compares the expression profile of immune cells in liver metastases and primary tumors in colorectal cancer patients. The researchers found differences in the spatial distribution of immune cells between these two types of tumors, with more immunosuppressive cells present in liver metastases, particularly macrophages with a CD68(-)CD163(+) phenotype.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Chao Wang, Yan Zhang, Wei-Qiang Gao
Summary: Prostate cancer is a common cancer among men in Western countries, and the standard therapy of ADT may lead to resistance and tumor progression. Recent data suggests that immune cells play important roles in the initiation, progression, metastasis, and treatment of prostate cancer.
Review
Cell Biology
Joshua Choi, Ellie Choi, Dongwon Choi
Summary: Lymphatic vessels not only serve as a vehicle for tumor metastasis but also play a role in suppressing cancer development through immune surveillance and fluid pressure drainage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vasilis Stavrinides, Joseph M. Norris, Solon Karapanagiotis, Francesco Giganti, Alistair Grey, Nick Trahearn, Alex Freeman, Aiman Haider, Lina Maria Carmona Echeverria, Simon R. J. Bott, Louise C. Brown, Nicholas Burns-Cox, Timothy J. Dudderidge, Ahmed El-Shater Bosaily, Maneesh Ghei, Alastair Henderson, Richard G. Hindley, Richard S. Kaplan, Robert Oldroyd, Chris Parker, Raj Persad, Derek J. Rosario, Iqbal S. Shergill, Mathias Winkler, Alex Kirkham, Shonit Punwani, Hayley C. Whitaker, Hashim U. Ahmed, Mark Emberton
Summary: This study assessed the impact of Gleason grade, maximum cancer core length (MCCL), inflammation, prostatic intraepithelial neoplasia (PIN), and atypical small acinar proliferation on the visibility of prostate MRI scans. The results showed that there was an incremental relationship between cancer burden and MRI visibility, while prostatic intraepithelial neoplasia contributed to false-positive MRI findings.
Review
Oncology
Chie Kudo-Saito, Yukinori Ozaki, Hiroshi Imazeki, Hideyuki Hayashi, Jun Masuda, Hiroki Ozawa, Yamato Ogiwara
Summary: Despite advances in tumor cell profiling and therapeutic agents, cancer metastasis remains a significant obstacle in treatment. Tumor cells evolving through interactions with the host environment lead to increased heterogeneity and complexity, making cancer difficult to treat. Understanding the entire metastatic process and targeting oncoimmune drivers is crucial to disrupting the vicious cycle of tumor-immunity aggravation.
Article
Cell Biology
Nelson K. Y. Wong, Xin Dong, Yen-Yi Lin, Hui Xue, Rebecca Wu, Dong Lin, Colin Collins, Yuzhuo Wang
Summary: Androgen deprivation therapy is the standard treatment for advanced prostate cancer, but most patients eventually relapse. The study of the dormant phase of prostate cancer progression is hindered by limited clinical tissue and preclinical models. This study uses unique patient-derived xenograft models to investigate the immune evasion mechanisms of dormant prostate cancer cells, providing a framework for further research and immune-based therapies.
Editorial Material
Oncology
Marvin E. Langston, Karen S. Sfanos, Saira Khan, Trang Q. Nguyen, Angelo M. De Marzo, Elizabeth A. Platz, Siobhan Sutcliffe
Summary: Inflammation is considered as a potential risk factor for prostate cancer, but patho-epidemiologic studies have shown inverse associations between intraprostatic inflammation and prostate cancer diagnosis. The presence of collider stratification bias may explain these inverse findings, and future studies should incorporate appropriate strategies to further investigate the etiology.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Benjamin A. Rybicki, Sudha M. Sadasivan, Yalei Chen, Ian Loveless, Nilesh S. Gupta, Dhananjay A. Chitale, Sean R. Williamson, Andrew G. Rundle, Deliang L. Tang
Summary: This study found that White men have longer telomeres in benign prostate tissue, and longer telomeres may be associated with increased risk for prostate cancer, particularly the more aggressive form of the disease.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Immunology
Chie Kudo-Saito, Narikazu Boku, Hidekazu Hirano, Hirokazu Shoji
Summary: Blocking immune inhibitory checkpoint pathways is a promising strategy for treating gastrointestinal cancer, but a distinct and effective treatment strategy is needed in clinical settings. Abnormality of myeloid cells may lead to refractory cancer, so eliminating and reprogramming tumor-supportive myeloid villains could be an effective breakthrough.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Kaiyuan Liu, Na Jing, Deng Wang, Penghui Xu, Jinming Wang, Xinyu Chen, Chaping Cheng, Zhixiang Xin, Yuman He, Huifang Zhao, ZhongZhong Ji, Pengcheng Zhang, Wei-Qiang Gao, Helen He Zhu, Kai Zhang
Summary: This study established an immune-intact mouse model for prostate cancer liver metastasis, which recapitulates the histological and lineage features of the original tumors and reveals dynamic tumor-immune cell communication in liver metastatic foci. The results suggest that the lack of CD8(+) T cells, enrichment of CD163(+) M2-like macrophages, and PD1(+)CD4(+) T cells contribute to an immunosuppressive microenvironment in prostate cancer liver metastasis.
CELL PROLIFERATION
(2021)
Article
Oncology
Guanliang Chen, Takashi Iwata, Masaki Sugawara, Hiroshi Nishio, Yuki Katoh, Iwao Kukimoto, Daisuke Aoki
Summary: The study aimed to identify predictors for the prognosis of CIN2 lesions and assess the prognostic value of the local immune response. Immunohistochemical analysis was conducted to determine the presence of p16-, MCM2-, or APOBEC3G-positive cells. Tumor-infiltrating lymphocytes (TILs) were scored using an automated system. The progression and regression rates of CIN3 were estimated, and a case-control study was performed to screen prognostic factors. CD4+ TIL infiltration was found to be related to CIN2 regression, suggesting its potential use for triaging patients.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shimei Li, Fanyi Xu, Xiangling Ren, Longfei Tan, Changhui Fu, Qiong Wu, Zengzhen Chen, Jun Ren, Zhongbing Huang, Xianwei Meng
Summary: This study proposes a nano-immunomodulator that releases H2S to reverse immunosuppression and reactivate the antitumor immune response, improving the efficacy of microwave thermal therapy. The nano-immunomodulator not only ablates tumors, but also inhibits the accumulation of immunosuppressive cells and promotes the expression of cytotoxic T lymphocytes. Additionally, it can scavenge immunosuppressive reactive oxygen species, enhancing the immune response.
Article
Oncology
Rebecca L. Mather, Abhijit Parolia, Sandra E. Carson, Erik Venalainen, David Roig-Carles, Mustapha Jaber, Shih-Chun Chu, Ilaria Alborelli, Rebecca Wu, Dong Lin, Noushin Nabavi, Elena Jachetti, Mario P. Colombo, Hui Xue, Perla Pucci, Xinpei Ci, Cheryl Hawkes, Yinglei Li, Hardev Pandha, Igor Ulitsky, Crystal Marconett, Luca Quagliata, Wei Jiang, Ignacio Romero, Yuzhuo Wang, Francesco Crea
Summary: Metastatic neuroendocrine prostate cancer (NEPC) is a highly aggressive disease with increasing incidence. The study identified LINC00261 as significantly upregulated in NEPC, driving proliferation and metastasis through effects on CBX2 and FOXA2. This indicates that LINC00261 may be utilized as a therapeutic target and a biomarker for NEPC.
MOLECULAR ONCOLOGY
(2021)
Article
Immunology
Barbara Bassani, Claudio Tripodo, Paola Portararo, Alessandro Gulino, Laura Botti, Claudia Chiodoni, Elena Jachetti, Niccolo Bolli, Marilena Ciciarello, Korinna Joehrens, Ioannis Anagnostopoulos, Il-Kang Na, Antonio Curti, Mario P. Colombo, Sabina Sangaletti
Summary: CD40+ BM-MSCs within the bone marrow play a crucial role in immune regulation, with loss of CD40 leading to uncontrolled T cell activation due to reduced Treg numbers and impaired B-cell development. This study highlights the importance of CD40 in maintaining Treg homeostasis and proper B-cell development in the context of bone marrow transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Claudia Enriquez, Valeria Cancila, Renata Ferri, Roberta Sulsenti, Irene Fischetti, Matteo Milani, Paola Ostano, Ilaria Gregnanin, Maurizia Mello-Grand, Enrico Berrino, Marco Bregni, Giuseppe Renne, Claudio Tripodo, Mario P. Colombo, Elena Jachetti
Summary: The study demonstrated a tumor-stroma cross-talk that induces neuroendocrine differentiation in prostate cancer under hormone therapy via a GRP78/ SPARC/ IL6 axis, highlighting potential therapeutic targets and biomarkers for neuroendocrine prostate cancer.
Article
Oncology
Simone Camelliti, Valentino Le Noci, Francesca Bianchi, Chiara Storti, Francesca Arnaboldi, Alessandra Cataldo, Serena Indino, Elena Jachetti, Mariangela Figini, Mario Paolo Colombo, Andrea Balsari, Nicoletta Gagliano, Elda Tagliabue, Lucia Sfondrini, Michele Sommariva
Summary: TLR9-stimulated macrophages interacting with the Fc domain of anti-PD-1 antibody acquire an immunoregulatory phenotype, leading to dampening of CpG-ODN antitumor effect. This may represent another possible mechanism of anti-PD-1 antibody therapy resistance.
Article
Biology
Claudio Tripodo, Barbara Bassani, Elena Jachetti, Valeria Cancila, Claudia Chiodoni, Paola Portararo, Laura Botti, Cesare Vaenti, Milena Perrone, Maurilio Ponzoni, Patrizia Comoli, Mara Lecchi, Paolo Verderio, Antonio Curti, Mario P. Colombo, Sabina Sangaletti
Summary: Neutrophil extracellular traps (NETs) are web-like chromatin structures composed of dsDNA and histones, decorated with antimicrobial proteins. Their interaction with dendritic cells (DCs) allows DC activation and maturation towards presentation of NET-associated antigens. NETs preserve the proteins localized onto the DNA threads for proper enzymatic activity and conformational status, including immunogenic epitopes. A NET/DC vaccine loaded with mutant NPMc+ NET effectively reduces myeloproliferation in transgenic mice and induces an anti-NPMc immune response.
Article
Oncology
Milena Perrone, Claudia Chiodoni, Mara Lecchi, Laura Botti, Barbara Bassani, Annamaria Piva, Elena Jachetti, Matteo Milani, Daniele Lecis, Elda Tagliabue, Paolo Verderio, Sabina Sangaletti, Mario P. Colombo
Summary: Cancer can reprogram the bone marrow niche through the BM mesenchymal stem cells (MSC) and IL-1B/ATF3 signaling pathway, which promotes myeloid cell differentiation and tumor development. The expression of CD11b thorn population in the peripheral blood can be used as a potential biomarker for early diagnosis of breast cancer. This study suggests that targeting IL-1B or ATF3 may have therapeutic benefits for breast cancer patients.
Article
Cell Biology
Raniero Chimenti, Tania Baccega, Silivia Torchio, Fabio Manenti, Silvia Pellegrini, Alessandro Cospito, Angelo Amabile, Marta Tiffany Lombardo, Paolo Monti, Valeria Sordi, Angelo Lombardo, Mauro Malnati, Lorenzo Piemonti
Summary: Induced pluripotent stem cells (iPSCs) are an important source for diabetes replacement therapy, but their application is limited by immune-mediated responses. This study found that iPSCs express high levels of the NK-activating ligands B7-H3 and CD155 during differentiation into pancreatic cells. By disrupting these ligands, the transplant compatibility of iPSC pancreatic derivatives can be enhanced.
Article
Immunology
Diego Signorelli, Patrizia Ghidotti, Claudia Proto, Marta Brambilla, Alessandro De Toma, Roberto Ferrara, Giulia Galli, Monica Ganzinelli, Giuseppe Lorusso, Arsela Prelaj, Mario Occhipinti, Giuseppe Viscardi, Valentina Capizzuto, Francesca Pontis, Ilaria Petraroia, Anna Maria Ferretti, Mario Paolo Colombo, Valter Torri, Gabriella Sozzi, Marina Chiara Garassino, Elena Jachetti, Orazio Fortunato
Summary: This study evaluated circulating EVs as potential biomarkers for ICI in NSCLC patients with low PD-L1. The results showed that higher levels of tetraspanins in R-EVs were associated with better treatment response and improved survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Arianna Brevi, Amir Zarrinpar
Article
Oncology
Riccardo Ray Colciago, Irene Fischetti, Carlotta Giandini, Eliana La Rocca, Tiziana T. Rancati, Alicia Rejas Mateo, Mario Paolo Colombo, Laura Lozza, Claudia Chiodoni, Elena Jachetti, Maria Carmen De Santis
Summary: Oncological treatments are rapidly changing with the introduction of targeted anticancer drugs and regimens, and radioimmunotherapy is emerging as a promising field. This review provides an overview of the synergistic use of radiotherapy and immunotherapy and addresses important questions about its implementation, the patient selection criteria, and when it becomes standard clinical practice.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Review
Pharmacology & Pharmacy
Roberta Sulsenti, Elena Jachetti
Summary: Tumor development, progression, and resistance to therapies are influenced by the interactions between tumor cells and the surrounding microenvironment, comprising fibroblasts, immune cells, and extracellular matrix proteins. In this context, mast cells (MCs) have recently emerged as important players. The role of MCs in promoting or inhibiting cancer growth is still controversial, and targeting MCs for cancer immunotherapy has become a potential strategy.
Meeting Abstract
Oncology
Roberto Ferrara, Giuseppe Lo Russo, Chiara Maura Ciniselli, Annamaria Piva, Barbara Bassani, Elena Jachetti, Giuseppina Calareso, Valeria Duroni, Settimio Di Gregorio, Claudia Proto, Arsela Prelaj, Alessandro De Toma, Mario Occhipinti, Marta Brambilla, Sara Manglaviti, Laura Mazzeo, Arturo Rinaldi, Teresa Beninato, Monica Ganzinelli, Filippo De Braud, Marina Chiara Garassino, Paolo Verderio, Mario Paolo Colombo, Sabina Sangaletti
Meeting Abstract
Immunology
Roberta Sulsenti, Valeria Cancila, Claudia Enriquez, Barbara Frossi, Renata Ferri, Laura Botti, Claudia Chiodoni, Carlo E. Pucillo, Claudio Tripodo, Mario P. Colombo, Elena Jachetti
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Oncology
Roberto Ferrara, Elena Jachetti, Giuseppina Calareso, Marta Brambilla, Giuseppe Lo Russo, Claudia Proto, Arsela Prelaj, Diego Signorelli, Giulia Galli, Alessandro De Toma, Mario Occhipinti, Sara Manglaviti, Alice Labianca, Monica Ganzinelli, Sestina Maria Spano, Giuliano Molino, Antonia Martinetti, Francesca Gabriella Greco, Marta Bini, Teresa Beninato, Filippo de Braud, Mario Paolo Colombo, Marina Chiara Garassino, Sabrina Sangaletti
Meeting Abstract
Oncology
D. Signorelli, O. Fortunato, F. Pontis, V. Capizzuto, R. Ferri, M. Brambilla, R. Ferrara, C. Proto, G. Lo Russo, A. Prelaj, G. Galli, A. De Toma, G. Viscardi, R. Lobefaro, F. Nichetti, M. Ganzinelli, N. Zilembo, M. Colombo, G. Sozzi, M. C. Garassino, E. Jachetti
JOURNAL OF THORACIC ONCOLOGY
(2021)