Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways
出版年份 2020 全文链接
标题
Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways
作者
关键词
-
出版物
Frontiers in Immunology
Volume 11, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2020-08-21
DOI
10.3389/fimmu.2020.01906
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
- (2019) Jason Miska et al. Cell Reports
- Interactive functions of microRNAs in the miR‐23a‐27a‐24‐2 cluster and the potential for targeted therapy in cancer
- (2019) Mengying Cui et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Effects of microRNA-24 targeting C-myc on apoptosis, proliferation, and cytokine expressions in chondrocytes of rats with osteoarthritis via MAPK signaling pathway
- (2018) Yuan-Hao Wu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment
- (2018) Sundary Sormendi et al. Frontiers in Immunology
- HIF-1α-induced miR-23a∼27a∼24 cluster promotes colorectal cancer progression via reprogramming metabolism
- (2018) Fangfang Jin et al. CANCER LETTERS
- Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer’s Disease and CNS-Related Disorders
- (2018) Athanasios Alexiou et al. MOLECULAR NEUROBIOLOGY
- IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours
- (2017) Hyungseok Seo et al. Nature Communications
- Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function
- (2017) Yael Gropper et al. Cell Reports
- LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma
- (2017) Ting-Ting Cai et al. PLoS Pathogens
- Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment
- (2017) Kathrin Renner et al. Frontiers in Immunology
- Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer
- (2017) Isobel S. Okoye et al. Frontiers in Immunology
- Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer
- (2016) Christian Bauer et al. CANCER LETTERS
- Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
- (2016) Michael D. Buck et al. CELL
- The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
- (2016) Nicole E. Scharping et al. IMMUNITY
- MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production
- (2016) Heather H. Pua et al. IMMUNITY
- Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion
- (2016) Bertram Bengsch et al. IMMUNITY
- miR-23∼27∼24 clusters control effector T cell differentiation and function
- (2016) Sunglim Cho et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Exosomal miR-24-3p impedes T-cell function by targetingFGF11and serves as a potential prognostic biomarker for nasopharyngeal carcinoma
- (2016) Shu-Biao Ye et al. JOURNAL OF PATHOLOGY
- A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer
- (2015) Björn von Eyss et al. CANCER CELL
- Phase I trial of adoptively transferred tumor-infiltrating lymphocyte immunotherapy following concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma
- (2015) Jiang Li et al. OncoImmunology
- COX-2 promotes metastasis in nasopharyngeal carcinoma by mediating interactions between cancer cells and myeloid-derived suppressor cells
- (2015) Ze-Lei Li et al. OncoImmunology
- Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors
- (2014) E. K. Moon et al. CLINICAL CANCER RESEARCH
- HIF Transcription Factors, Inflammation, and Immunity
- (2014) Asis Palazon et al. IMMUNITY
- c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells
- (2014) Chun Chou et al. NATURE IMMUNOLOGY
- PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
- (2013) Francisca Vazquez et al. CANCER CELL
- A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells
- (2013) I. B. Barsoum et al. CANCER RESEARCH
- HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression
- (2013) B. Philip et al. CARCINOGENESIS
- Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
- (2013) Marc Liesa et al. Cell Metabolism
- Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
- (2013) Andrew L Doedens et al. NATURE IMMUNOLOGY
- Tumor and its microenvironment: A synergistic interplay
- (2013) Veronica Catalano et al. SEMINARS IN CANCER BIOLOGY
- The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity
- (2013) Joanna Baginska et al. Frontiers in Immunology
- Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8+ T cells sensitizing them to apoptotic cell death
- (2012) Stefan Brunner et al. AGING CELL
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
- (2011) Eric V. Dang et al. CELL
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- T cell exhaustion
- (2011) E John Wherry NATURE IMMUNOLOGY
- Early T Cell Signalling Is Reversibly Altered in PD-1+ T Lymphocytes Infiltrating Human Tumors
- (2011) Shu-Fang Wang et al. PLoS One
- Hypoxia-driven immunosuppression: A new reason to use thermal therapy in the treatment of cancer?
- (2010) Chen-Ting Lee et al. INTERNATIONAL JOURNAL OF HYPERTHERMIA
- Mitochondrial fusion proteins: Dual regulators of morphology and metabolism
- (2010) Antonio Zorzano et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
- (2008) Liang Zhou et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now