Article
Immunology
Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Grafitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg
Summary: The study found that epitope-specific anti-C1q in SLE patients is associated with specific disease manifestations, providing more diagnostic value than conventional anti-C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Hsin-Hua Chen, Ching-Heng Lin, Wen-Cheng Chao
Summary: The study revealed a strong association between APS and the risk of newly diagnosed SLE, with APS patients having a significantly higher risk of developing SLE within 5 years compared to non-APS individuals. This association remained robust even after propensity score matching, suggesting the need for close monitoring and early detection of SLE symptoms in patients with APS.
FRONTIERS IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Silvia Cavalli, Paola Adele Lonati, Maria Gerosa, Roberto Caporali, Rolando Cimaz, Cecilia Beatrice Chighizola
Summary: The complement system has a significant role in various rheumatologic conditions, including rheumatoid arthritis, psoriatic arthritis, Sjogren syndrome, systemic sclerosis, vasculitides, and dermatomyositis. Complement deposition is associated with disease severity, and serum complement levels may serve as potential markers for evaluating disease activity. In pregnancy, the complement system also plays a crucial role, and alterations in complement levels may be associated with pregnancy complications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Nuria Banos, Aleida Castellanos, Giuseppe Barilaro, Francesc Figueras, Gema Lledo, Marta Santana, Gerard Espinosa
Summary: A prospective study was conducted on pregnant women with SLE, antiphospholipid syndrome, or non-criteria obstetric antiphospholipid syndrome to develop a predictive tool for adverse pregnancy outcomes. Baseline characteristics and certain biomarkers were found to be predictive of adverse outcomes, highlighting the need for better biomarkers for pregnant women with autoimmune diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Massimo Radin, Irene Cecchi, Francesca Crisafulli, Evandro Mendes Klumb, Guilherme Ramires de Jesus, Marcela Ignacchiti Lacerda, Miguel Angel Saavedra, Geraldine Vanessa Reyes-Navarro, Luca Iaccarino, Maddalena Larosa, Gabriella Moroni, Francesco Tamborini, Dario Roccatello, Laura Andreoli, Savino Sciascia, Cecilia Beatrice Chighizola
Summary: A network meta-analysis of 19 studies found that complement levels, specifically C3 and C4, gradually increased during gestation in lupus pregnant women. However, patients with lupus nephritis and gestational flares had significantly lower complement levels at all timepoints. Particularly in early gestation, a reduction or smaller increase in C3 and C4 levels, even within the normal range, may predict gestational flares.
AUTOIMMUNITY REVIEWS
(2023)
Article
Immunology
Natalia Egri, Chelsea Bentow, Laura Rubio, Gary L. Norman, Susana Lopez-Sanudo, Michael Mahler, Albert Perez-Isidro, Ricard Cervera, Odette Vinas, Gerard Espinosa, Estibaliz Ruiz-Ortiz
Summary: The study found that persistently positive results for aPS/PT IgG antibodies were significantly associated with APS classification, thrombosis, triple aPL positivity, LA positive result, and the Global APS Score (GAPSS) > than 9 points, but not with pregnancy morbidity and SLE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Caroline Carle, Francoise Fortenfant, Marie Tauber, Emilie Tournier, Carle Paul, Chloe Bost, Yves Renaudineau
Summary: The lupus band test is debated for its ability to distinguish between cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE), and its association with antinuclear antibodies (ANA) and complement reduction. Certain clinical, histopathologic, and serological parameters can effectively differentiate lupus from other skin disorders and distinguish between SLE and CLE.
CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nayra Merino de Paz, Maria Garcia-Gonzalez, Fuensanta Gomez-Bernal, Juan C. Quevedo-Abeledo, Antonia de Vera-Gonzalez, Raquel Lopez-Mejias, Pedro Abreu-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: Malondialdehyde (MDA) is a marker of oxidative stress and antioxidant status. This study found that cumulative musculoskeletal and skin damage in SLE patients is associated with higher serum levels of MDA. In addition, activation of the complement system is also related to higher circulating MDA levels.
Review
Biochemistry & Molecular Biology
Masahiro Ayano, Takahiko Horiuchi
Summary: Systemic lupus erythematosus (SLE) is a disease where complement is crucial in its pathogenesis. Complement levels in blood and histological tests are used for SLE management, and the evaluation of complement status is useful for diagnosis, disease activity assessment, treatment response prediction, and prognosis. Novel complement biomarkers are more sensitive than traditional markers and have wider application. This review summarizes the utility of complement testing in SLE management over the last decade.
Article
Immunology
Maria Garcia-Gonzalez, Fuensanta Gomez-Bernal, Juan C. C. Quevedo-Abeledo, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Inigo de la Rua-figueroa, Raquel Lopez-Mejias, Federico Diaz-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study assessed the function of the three complement pathways in SLE patients and found that AL and LE pathways had lower functional values compared to the CL pathway. Clinical activity was not related to functional values of the C pathways, but increased DNA binding was negatively associated. Disease damage was positively correlated with C pathways and components. Anti-ribosomes and anti-nucleosomes antibodies showed a higher relationship with C activation, mainly through the LE and CL pathways. IgG anti-beta 2GP antibodies were most closely related to C activation, predominantly involving the AL pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Wojciech Lubon, Malgorzata Lubon, Przemyslaw Kotyla, Ewa Mrukwa-Kominek
Summary: Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease, with up to one-third of patients experiencing various ocular manifestations. Ocular findings may be the initial signs of the disease and can lead to severe complications and vision loss. Early diagnosis and proper management are crucial, requiring collaboration among specialists. Adequate preparation of ophthalmologists can help differentiate SLE complications from other eye disorders. New therapies for SLE show promise, but their ocular side effects are still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Fengping Liu, Tianli Ren, Xiaodi Li, Qixiao Zhai, Xifeng Xu, Nan Zhang, Peng Jiang, Yaofang Niu, Longxian Lv, GuoXun Shi, Ninghan Feng
Summary: The microbiome alterations in the gut and oral cavity are associated with the development of systemic lupus erythematosus (SLE). Research on 35 SLE patients revealed reduced bacterial richness and diversity in feces, and increased bacterial diversity in saliva. These findings suggest that different body niches in SLE patients have distinct bacterial profiles that may play a role in the disease development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Maddalena Larosa, Veronique Le Guern, Gaelle Guettrot-Imbert, Nathalie Morel, Noemie Abisror, Chafika Morati-Hafsaoui, Pauline Orquevaux, Elisabeth Diot, Andrea Doria, Francoise Sarrot Reynauld, Nicolas Limal, Viviane Queyrel, Odile Souchaud-Debouverie, Laurent Sailler, Maelle Le Besnerais, Tiphaine Goulenok, Anna Molto, Emmanuelle Pannier-Metzger, Loic Sentilhes, Luc Mouthon, Estibaliz Lazaro, Nathalie Costedoat-Chalumeau
Summary: The specific roles of remission status, lupus low disease activity state (LLDAS), and damage accrual on the prognosis of pregnancies in women with SLE are unknown. This study found that damage at conception and lupus anticoagulant were significantly associated with adverse pregnancy outcomes, while hypocomplementemia in the first trimester was associated with maternal flares later in pregnancy.
Article
Medicine, General & Internal
Maria Garcia-Gonzalez, Fuensanta Gomez-Bernal, Juan C. Quevedo-Abeledo, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Raquel Lopez-Mejias, Federico Diaz-Gonzalez, Miguel a. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study analyzed the relationship between the complement (C) system and cholesterol efflux capacity (CEC) in patients with systemic lupus erythematosus (SLE). The study found that there is an interconnected relationship between the C system and CEC in patients with SLE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Ji-Won Kim, Ju-Yang Jung, Hyoun-Ah Kim, Jeong Yang, Dong W. Kwak, Chang-Hee Suh
Summary: This study aimed to examine the frequency and risk factors of complications during pregnancy in women with systemic lupus erythematosus (SLE). The results showed that pregnant women with SLE have a higher risk of adverse pregnancy outcomes and pregnancies should be delayed until achieving LLDAS and should be closely monitored with the lowest possible dose of CS.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Nicolo Costantino Brembilla, Aleksandra Maria Dufour, Montserrat Alvarez, Stephanie Hugues, Elisa Montanari, Marie-Elise Truchetet, Paola Lonati, Lionel Fontao, Armando Gabrielli, Serena Vettori, Gabriele Valentini, Wolf-Henning Boehncke, Pierluigi Meroni, Carlo Chizzolini
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Article
Immunology
Francesco Tedesco, Maria Orietta Borghi, Maria Gerosa, Cecilia Beatrice Chighizola, Paolo Macor, Paola Adele Lonati, Alessandro Gulino, Beatrice Belmonte, Pier Luigi Meroni
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Paola Adele Lonati, Mariangela Scavone, Maria Gerosa, Maria Orietta Borghi, Francesca Pregnolato, Daniele Curreli, Gianmarco Podda, Eti Alessandra Femia, Wilma Barcellini, Marco Cattaneo, Francesco Tedesco, Pier Luigi Meroni
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Pharmacology & Pharmacy
Orazio De Lucia, Luca Massimo Pierannunzii, Francesca Pregnolato, Elisa Verduci, Chiara Crotti, Elisabetta Valcamonica, Laura Pisoni, Daniela Comi, Paola Adele Lonati, Pier Luigi Meroni, Antonella Murgo
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Rheumatology
Francesca Pregnolato, Maria Gerosa, Maria Gabriella Raimondo, Chiara Comerio, Francesca Bartoli, Paola A. Lonati, Maria Orietta Borghi, Barbara Acaia, Manuela Wally Ossola, Enrico Ferrazzi, Laura Trespidi, Pier Luigi Meroni, Cecilia B. Chighizola
Summary: This study investigates the impact of aPL positivity at different titres on pregnancy morbidity, finding that low-titre aPL and aPL fulfilling classification criteria significantly impact the risk of PM. The combination of LDASA and LMWH can significantly reduce the probability of PM in all women with low-titre aPL and criteria aPL.
Article
Endocrinology & Metabolism
Claudia Grossi, Carolina Artusi, PierLuigi Meroni, Maria Orietta Borghi, Laura Neglia, Paola Adele Lonati, Marco Oggioni, Francesco Tedesco, Maria-Grazia De Simoni, Stefano Fumagalli
Summary: Beta-2 Glycoprotein I plays a role in brain injury following ischemic stroke by triggering hepatic production, enhancing vascular inflammation, interacting with mannose-binding lectin, and binding stressed neurons for clearance by phagocytosis.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Valentina Alari, Paolo Scalmani, Paola Francesca Ajmone, Sara Perego, Sabrina Avignone, Ilaria Catusi, Paola Adele Lonati, Maria Orietta Borghi, Palma Finelli, Benedetta Terragni, Massimo Mantegazza, Silvia Russo, Lidia Larizza
Summary: Research shows that histone deacetylase inhibitors can partially improve morphological abnormalities in Rubinstein-Taybi syndrome patients' neurons and increase their excitability. Additionally, the use of a certain concentration of valproic acid also has an effect on the abnormalities of the patients' neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Silvia Cavalli, Paola Adele Lonati, Maria Gerosa, Roberto Caporali, Rolando Cimaz, Cecilia Beatrice Chighizola
Summary: The complement system has a significant role in various rheumatologic conditions, including rheumatoid arthritis, psoriatic arthritis, Sjogren syndrome, systemic sclerosis, vasculitides, and dermatomyositis. Complement deposition is associated with disease severity, and serum complement levels may serve as potential markers for evaluating disease activity. In pregnancy, the complement system also plays a crucial role, and alterations in complement levels may be associated with pregnancy complications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Paola Adele Lonati, Caterina Bodio, Mariangela Scavone, Giuliana Martini, Elisa Pesce, Alessandra Bandera, Andrea Lombardi, Maria Gerosa, Franco Franceschini, Angela Tincani, Gianmarco Podda, Sergio Abrignani, Renata Grifantini, Marco Cattaneo, Maria Orietta Borghi, Pier Luigi Meroni
Summary: The study found that COVID-19 vaccination does not affect the production of anti-PF4 antibodies and their ability to cause platelet activation in aPL-positive patients.
Article
Immunology
Maria Orietta Borghi, Mauro Bombaci, Caterina Bodio, Paola Adele Lonati, Andrea Gobbini, Mariangela Lorenzo, Erminio Torresani, Antonella Dubini, Ilaria Bulgarelli, Francesca Solari, Francesca Pregnolato, Alessandra Bandera, Andrea Gori, Gianfranco Parati, Sergio Abrignani, Renata Grifantini, Pier Luigi Meroni
Summary: Molecular mimicry between SARS-CoV-2 and human proteins may result in autoimmunity during COVID-19. Vaccination does not induce early autoimmune response but occasionally leads to low levels of autoantibodies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pier Luigi Meroni, Stefania Croci, Paola Adele Lonati, Francesca Pregnolato, Lucia Spaggiari, Giulia Besutti, Martina Bonacini, Ilaria Ferrigno, Alessandro Rossi, Geir Hetland, Ivana Hollan, Massimo Cugno, Francesco Tedesco, Maria Orietta Borghi, Carlo Salvarani
Summary: COVID-19 can cause a multi-organ disease with hyperinflammation and prothrombotic response. The activation of complement is associated with disease severity and outcome.
AUTOIMMUNITY REVIEWS
(2023)
Article
Hematology
Marta Brambilla, Paola Canzano, Patrizia Della Valle, Alessia Becchetti, Maria Conti, Mariangela Alberti, Arianna Galotta, Maria Luisa Biondi, Paola Adele Lonati, Fabrizio Veglia, Alice Bonomi, Nicola Cosentino, Pier Luigi Meroni, Gian Vincenzo Zuccotti, Armando D'Angelo, Marina Camera
Summary: This study evaluated the impact of four COVID-19 vaccines on platelet activation, coagulation, and inflammation. It found that vaccination did not induce platelet activation and microvesicle release. Although there were minor changes in clotting activation and endothelial function, these could potentially explain the rare venous thromboembolic complications of COVID-19 vaccination at a population level.
THROMBOSIS RESEARCH
(2023)
Article
Rheumatology
Elena Raschi, Daniela Privitera, Caterina Bodio, Paola Adele Lonati, Maria Orietta Borghi, Francesca Ingegnoli, Pier Luigi Meroni, Cecilia Beatrice Chighizola
ARTHRITIS RESEARCH & THERAPY
(2020)
Meeting Abstract
Rheumatology
Maria Gerosa, Paola Adele Lonati, Tania Ubiali, Martina Cornalba, Maria Orietta Borghi, Pier Luigi Meroni
ARTHRITIS & RHEUMATOLOGY
(2015)