期刊
CURRENT OPINION IN RHEUMATOLOGY
卷 28, 期 2, 页码 127-132出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/BOR.0000000000000244
关键词
articular cartilage vesicles; autophagy; basic calcium phosphate crystals; calcium pyrophosphate; chondrocalcinosis; chondrocytes; exosomes; matrix vesicles; pseudogout
类别
资金
- Department of Veterans Affairs, Merit Review Grants [BX000812, CX001143]
Purpose of reviewArticular cartilage vesicles (ACVs) are small extracellular vesicles that serve as foci of pathologic calcium crystal deposition in articular cartilage matrix. In this review, I have summarized the role of ACVs in calcium crystal formation and discuss recent findings that impact our understanding of the content, behavior, and origin of ACVs in healthy and diseased joints. The burgeoning interest in extracellular vesicles in other fields renders this a timely and relevant topic.Recent findingsI have highlighted recent studies demonstrating that some ACVs originate in the autophagic pathway in healthy articular chondrocytes. I have reviewed accumulating evidence that nonmineralizing functions of ACVs contribute to osteoarthritis. I have also discussed new work supporting a role for extracellular vesicles in interleukin-1-induced mineralization and in mediating the catabolic effects of synovial inflammation in osteoarthritis.SummaryWe are making slow and steady progress in understanding the origin and function of ACVs and other relevant extracellular vesicles in arthritis. Further work in this interesting area is warranted.
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