Review
Medicine, Research & Experimental
Ning Li, Yi Chen Gong, Jianer Chen
Summary: The study found that intranasal salmon calcitonin can decrease blood calcium levels, increase creatinine and alkaline phosphatase ratios, but does not show distinct advantages in other indicators. It cannot be proven that the combination of intranasal salmon calcitonin with other conventional drugs is more effective than using conventional drugs alone.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Review
Medicine, General & Internal
YuLong Ouyang, ShuiLin Chen, Ting Wan, GuiHao Zheng, GuiCai Sun
Summary: The study found that teriparatide was more effective than bisphosphonates in preventing fractures in postmenopausal women with osteoporosis, including vertebral and non-vertebral fractures, with similar rates of adverse effects. More high-quality studies are needed to compare other factors such as costs and adverse reactions.
Review
Pharmacology & Pharmacy
Yang Sun, Yue Li, Jiangbi Li, Xiaoping Xie, Feng Gu, Zhenjiang Sui, Ke Zhang, Tiecheng Yu
Summary: The study found that a combination treatment of teriparatide and denosumab in postmenopausal osteoporosis patients leads to greater increase in bone density compared to monotherapy, without significant difference in adverse events.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Multidisciplinary Sciences
Zhi-Ming Liu, Min Zhang, Yuan Zong, Ding Zhang, Zhu-Bin Shen, Xiao-Qing Guan, Fei Yin
Summary: This study aimed to compare the efficacy of alendronate and teriparatide in the treatment of glucocorticoid-induced osteoporosis. The study found that compared to alendronate, teriparatide could reduce the rate of new vertebral fractures and increase the bone mineral density of the lumbar spine, femoral neck, and total hip. There was no significant difference in the incidence of non-vertebral fractures and adverse events between the two groups.
Review
Orthopedics
Chuanjian Yuan, Yanchen Liang, Kai Zhu, Wenpeng Xie
Summary: This study compared the efficacy and safety of teriparatide and denosumab with oral bisphosphonates. The results showed that teriparatide and denosumab were superior to bisphosphonates in increasing bone mineral density and preventing vertebral fractures. Therefore, teriparatide and denosumab may be considered as first-line treatments for glucocorticoid-induced osteoporosis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Endocrinology & Metabolism
K. Eastman, M. Gerlach, I. Piec, J. Greeves, W. Fraser
Summary: This meta-analysis evaluated the evidence for the use of parathyroid hormone (PTH) analogues to improve fracture healing. PTH improved functional outcomes but did not affect fracture healing rate or reduce pain. The evidence for PTH analogue use in fracture healing is less clear in younger, non-osteoporotic patient populations, warranting further research.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Orthopedics
Pan Hong, Ruikang Liu, Saroj Rai, JiaJia Liu, YeMing Zhou, Yu Zheng, Jin Li
Summary: The purpose of this study was to evaluate the effectiveness and safety of Abaloparatide (ABL) compared to Teriparatide (TPTD) in improving bone mineral density (BMD). The results showed that ABL had a better effect on BMD improvement in postmenopausal women compared to placebo and TPTD, and the risk of adverse events with ABL was slightly lower than TPTD. ABL is an alternative option for postmenopausal women with osteoporosis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Yao Li, Xiao-Jie Ju, Han Fu, Chang-Hai Zhou, Yi Gao, Jun Wang, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: A composite separable microneedles system consisting of silk fibroin needle tips and hyaluronic acid base is developed for transdermal delivery of salmon calcitonin for therapy of osteoporosis. The release of salmon calcitonin can be controlled by modulating the conformation structure of silk fibroin and the interaction between salmon calcitonin peptide and silk fibroin proteins.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Clinical Neurology
Vaidya Govindarajan, Anthony Diaz, Roberto J. Perez-Roman, S. Shelby Burks, Michael Y. Wang, Allan D. Levi
Summary: This study conducted a systematic evaluation of the efficacy of using bisphosphonates and teriparatide in improving spinal fusion outcomes in osteoporotic patients. The results showed that bisphosphonate users had a higher likelihood of successful fusion during short-term monitoring, while teriparatide significantly increased fusion rates during long-term postoperative periods.
NEUROSURGICAL FOCUS
(2021)
Review
Medicine, General & Internal
Na Liang, Shuang Zhang, Shuang Wang, Juan Ma
Summary: This study protocol aims to evaluate the efficacy and safety of alendronate and teriparatide for patients with glucocorticoid-induced osteoporosis, providing evidence-based guidance for treating these patients.
Article
Medicine, General & Internal
Gongwei Zhai, Ang Li, Binfeng Liu, Dongbo Lv, Jingyi Zhang, Weichao Sheng, Guang Yang, YanZheng Gao
Summary: Bone mineral density, cement leakage, and kyphosis after primary operation are the risk factors closely associated with secondary fractures after PVP. There is insufficient evidence to support the association between secondary fractures and gender, age, body mass index, cement volume, thoracolumbar spine, and cement injection approaches.
Review
Geriatrics & Gerontology
Abadi K. Gebre, Joshua R. Lewis, Kevin Leow, Pawel Szulc, David Scott, Peter R. Ebeling, Marc Sim, Germaine Wong, Wai H. Lim, John T. Schousboe, Douglas P. Kiel, Richard L. Prince, Alexander J. Rodriguez
Summary: Abdominal aortic calcification (AAC) is associated with lower bone mineral density (BMD) and increased fracture risk. Detecting AAC during BMD testing may provide guidance for diagnosing bone health and predicting fracture risk.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Geriatrics & Gerontology
Kiarash Tanha, Noushin Fahimfar, Shahrzad Nematollahi, Sayed Mahmoud Sajjadi-Jazi, Safoora Gharibzadeh, Mahnaz Sanjari, Kazem Khalagi, Fatemeh Hajivalizedeh, Alireza Raeisi, Bagher Larijani, Afshin Ostovar
Summary: This study aimed to estimate the annual incidence of osteoporotic fractures in Iran, showing a high incidence rate of osteoporotic hip fractures. The study recommends early detection and treatment of individuals with higher risks, as well as implementing fracture liaison services to prevent secondary fractures.
Review
Nutrition & Dietetics
Ligia J. Dominguez, Nicola Veronese, Stefano Ciriminna, Jose Luis Perez-Albela, Vania Flora Vasquez-Lopez, Santiago Rodas-Regalado, Giovanna Di Bella, Angela Parisi, Federica Tagliaferri, Mario Barbagallo
Summary: This systematic review and meta-analysis aimed to investigate the impact of serum magnesium on the risk of fractures. Four papers with a total of 119,755 participants were included in the systematic review. The findings suggested that lower serum magnesium concentrations were associated with a significantly higher risk of incident fractures. Further research is needed to confirm these results in other populations and explore the potential role of serum magnesium in fracture prevention.
Review
Clinical Neurology
Tao-Yin Pan, Chien-Chun Chang, Hsien-Te Chen, Hsi-Kai Tsou, Ying-Chao Lin, Chin-Hsien Hsu
Summary: This study aims to evaluate the effectiveness of teriparatide in improving radiographic and functional outcomes after spinal fusion surgery for osteoporosis. Through systematic review and network meta-analysis, the results showed significant differences in radiological outcomes, with TP group exhibiting better outcomes compared to the control group.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Changjun Chen, Xianlei Gao, Hao Li, Xin Pan, Songgang Wang
Summary: This study introduced a less invasive technique for treating stage III Kummell disease, showing significant improvement in pain relief, anterior column height recovery, and kyphotic angle correction. The intravertebral insertion of interbody fusion cage via transpedicular approach provided advantages of acceptable correction of kyphosis, bony fusion, and minimal invasion, making it a good alternative choice for stage III Kummell disease.
BRITISH JOURNAL OF NEUROSURGERY
(2021)
Article
Orthopedics
Mohammed Alqwbani, Zhuoer Wang, Qiuru Wang, Qianhao Li, Zhouyuan Yang, Pengde Kang
Summary: This study evaluated the mid-term clinical and radiological outcomes of using porous tantalum trabecular metal (TM) shell and augment to reconstruct acetabular defects in revision total hip arthroplasty. The results showed satisfactory implant survival, pain relief, functional outcomes, and patient satisfaction.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Immunology
Changjun Chen, Xin Zhao, Yue Luo, Bohua Li, Qianhao Li, Chengcheng Zhao, Yan Huang, Pengde Kang
Summary: The imbalance of T-cell subsets may be involved in the pathophysiological process of ONFH, and diminished CD4(+)/FoxP3(+) T regulatory cells may be associated with increased RANKL(+) T cells in the bone marrow of the femoral head in GC-ONFH, which may facilitate bone resorption and collapse of the femoral head.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Orthopedics
Cheng-cheng Zhao, Li-yile Chen, Chang-jun Chen, Qiu-ru Wang, Qian-hao Li, Peng-de Kang
Summary: This study compared blood loss and indicators of coagulation and fibrinolysis between total knee arthroplasty (TKA) patients living at low or high altitudes. The results showed that total blood loss was significantly higher in the high-altitude group compared to the low-altitude group. The high-altitude group also exhibited prolonged coagulation parameters and increased levels of fibrinogen/fibrin degradation product. Ecchymosis was more frequent in the high-altitude group. However, transfusion rates and incidence of thromboembolic events and complications were similar between the two groups.
INTERNATIONAL ORTHOPAEDICS
(2023)
Review
Orthopedics
Changjun Chen, Xin Zhao, Yue Luo, Liyile Chen, Pengde Kang
Summary: Recent guidelines have provided a consensus statement on perioperative care in hip and knee replacement, but more analysis of the evidence and recommendations is needed. We conducted a retrieval and reanalysis of the evidence for each recommended component of enhanced recovery after surgery (ERAS) based on total joint arthroplasty guidelines. We found that most recommended components are supported by evidence, but the implementation details of each component need further optimization. Therefore, the full implementation of an ERAS program may maximize the benefits of clinical practice, but its combined effect still needs to be determined.
ORTHOPAEDIC SURGERY
(2023)
Article
Nanoscience & Nanotechnology
Changjun Chen, Li Fu, Yue Luo, Weinan Zeng, Xin Qi, Yang Wei, Liyile Chen, Xin Zhao, Donghai Li, Meng Tian, Pengde Kang
Summary: This study presents an engineered exosome-functionalized extracellular matrix-mimicking hydrogel for promoting bone repair in glucocorticoid-induced osteonecrosis of the femoral head (GC-ONFH). The hydrogel, composed of methacryloylated type I collagen, incorporates exosomes derived from lithium ion-stimulated bone marrow stem cells (Li-Exo) or conventional culture medium-stimulated bone marrow stem cells (Con-Exo). In vitro studies demonstrate that the Lightgel-Li-Exo hydrogel has the most significant pro-osteogenic and pro-angiogenic activity. In rat models of GC-ONFH, the Lightgel-Li-Exo hydrogel shows the most pronounced effects on enhancing macrophage M2 polarization, osteogenesis, and angiogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Editorial Material
Clinical Neurology
Changjun Chen, Yanjun Ren, Yubin Qi, Guihui Zhang, Hongguang Hu, Kaining Zhang, Yingguang Wu, Yun Yang
ANNALS OF NEUROLOGY
(2023)
Article
Developmental Biology
Xin Zhao, Changjun Chen, Yue Luo, Donghai Li, Qiuru Wang, Yuying Fang, Pengde Kang
Summary: This study demonstrated for the first time that the overexpression of Cx43 in BMSCs could promote bone regeneration and angiogenesis, suggesting that Cx43 may serve as a therapeutic gene target for GIONFH treatment.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Liyile Chen, Zeyu Huang, Qianhao Li, Changjun Chen, Yue Luo, Pengde Kang
Summary: This study evaluated the role of aryl hydrocarbon receptor (AhR) in the pathogenesis of osteoarthritis (OA) and its association with intestinal microbiome-related tryptophan metabolism. The severity of OA positively correlated with the expression of AhR and CyP1A1 in cartilage from patients. In a rat model of OA, antibiotic pretreatment led to lower expression of AhR and CyP1A1 and lower serum levels of lipopolysaccharide (LPS). Tryptophan supplementation activated intestinal microbiome-related tryptophan metabolism, exacerbating OA synovitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Orthopedics
Changjun Chen, Jingkun Li, Yun Yang, Yingguang Wu, Yanjun Ren, Debo Zou, Kaining Zhang, Pengde Kang
Summary: Enhanced recovery after surgery (ERAS) is a pathway that aims to improve surgical patient care and achieve early recovery. This article provides an overview of the latest clinical outcomes and current usage of key elements of ERAS pathways in total joint arthroplasty (TJA).
ORTHOPAEDIC SURGERY
(2023)
Letter
Oncology
Chang Jun Chen, Li Feng Ci, Yan Wang, Gui Hui Zhang, Yan Jun Ren, Yu Bin Qi, Ying Guang Wu, Kai Ning Zhang, Yun Yang
WORLD JOURNAL OF ONCOLOGY
(2023)
Letter
Rheumatology
Xiaojie Ma, Xin Zhao, Yubin Qi, Houying Li, Li Hu, Zhenxing Zhang, Kaining Zhang, Yanjun Ren, Yun Yang, Changjun Chen
Review
Allergy
Changjun Chen, Meng Si, Xianlei Gao, Wenhan Wang, Songgang Wang, Xin Pan
Summary: The main cutaneous manifestations of primary cutaneous diffuse large B-cell lymphoma (PCDLBCL) include infiltrative lesions, and treatment options include excision, radiotherapy, chemotherapy, with systemic chemotherapy using rituximab combined with other drugs showing better efficacy.
POSTEPY DERMATOLOGII I ALERGOLOGII
(2022)