Article
Medicine, General & Internal
Karima Abdelfattah Bahgat, Marwa Elhady, Tawfik Abd Elatey Alkholy, Fatma Mohamed Abd Elgaber, Walaa Shipl, Ayman A. Gobarah
Summary: Central obesity and decreased BDNF are independent predictors for SDB in obese children. Anthropometric indices adjusted to height are a simple screening tool for SDB in obese children.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Clinical Neurology
Leo Sher, Linda M. Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda
Summary: This study found that plasma BDNF levels were higher among combat veterans who made suicide attempts post-deployment compared to those who did not. BDNF may be involved in the pathophysiology of suicidal behavior in this population.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biology
Andonia Petkova-Tuffy, Nina Goedecke, Julio Viotti, Martin Korte, Thomas Dresbach
Summary: The study reveals that NL1 and BDNF act together to play a crucial role in synaptic maturation, including increasing the stability of active zones and recycling of synaptic vesicles, a process that relies on a transsynaptic pathway between them. Using BDNF can mimic the effects of NL1 overexpression on structural and functional maturation, while blocking BDNF signaling can prevent the effects of NL1 on presynaptic maturation.
Article
Multidisciplinary Sciences
Carlos Berlanga-Macias, Mairena Sanchez-Lopez, Montserrat Solera-Martinez, Ana Diez-Fernandez, Inmaculada Ballesteros-Yanez, Carlos A. Castillo-Sarmiento, Isabel A. Martinez-Ortega, Vicente Martinez-Vizcaino
Summary: This study found no significant positive association between exclusive breastfeeding and BDNF serum levels in Spanish schoolchildren aged eight to 11 years. Regardless of breastfeeding duration, age group, or sexual maturation, BDNF levels did not show significant differences, indicating that exclusive breastfeeding may not have a significant impact on BDNF levels in this age group.
Review
Behavioral Sciences
Ya-Hai Wang, Huan-Huan Zhou, Qiang Luo, Sidong Cui
Summary: This study investigated the effects of physical exercise on brain-derived neurotrophic factor (BDNF) in healthy individuals. The findings showed that both acute and long-term exercise had significant positive effects on circulating BDNF levels. Subgroup analysis revealed that long-term aerobic exercise, female participants, participants older than 60 years, and aerobic exercise contributed to a more pronounced improvement in BDNF levels.
BRAIN AND BEHAVIOR
(2022)
Review
Clinical Neurology
Sarah K. Ashcroft, Daniel D. Ironside, Liam Johnson, Suzanne S. Kuys, Angelica G. Thompson-Butel
Summary: This systematic review and meta-analysis of 17 studies found that high intensity aerobic exercise can increase circulating BDNF concentrations, which may contribute to increased neuroplasticity in individuals poststroke.
Article
Neurosciences
Shristi Khanal, Eugene Bok, Jaekwang Kim, Gyu Hwan Park, Dong-Young Choi
Summary: Parkinson's disease (PD) is a common neurodegenerative disease without known cure or therapy. Inosine, a purine nucleoside, can protect neuroblastoma cells and dopaminergic neurons through brain-derived neurotrophic factor (BDNF) upregulation and activation of its downstream signaling pathway. Adenosine receptors A1 and A2A play critical roles in mediating the neuroprotective effects of inosine. Inosine shows therapeutic potential in treating dopaminergic neurodegeneration in PD.
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Davide Gusmeo Curti, Rosalyn Moran, Peter J. Goadsby, Ivana Rosenzweig, Caterina Lombardo
Summary: The brain-derived neurotrophic factor (BDNF) is considered a transdiagnostic biomarker for mental disorders and is associated with emotional and cognitive functioning. A systematic review and meta-analysis of case-control studies were conducted to examine the levels of peripheral BDNF in individuals with insomnia. The results showed that subjects with insomnia had lower BDNF levels compared to healthy controls. However, the interpretation of the results should be cautious due to the small sample size, cross-sectional nature of the measurement, and high heterogeneity of the included data.
SLEEP MEDICINE REVIEWS
(2023)
Review
Behavioral Sciences
Ryoki Sasaki, Shota Miyaguchi, Hideaki Onishi
Summary: Studies suggest that BDNF genotype may have a minor impact on individual motor performance and motor learning abilities.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychiatry
Hayley Dingsdale, Samantha M. Garay, Hannah R. Tyson, Katrina A. Savory, Lorna A. Sumption, Jemima S. Kelleher, Kate Langley, Stephanie Van Goozen, Rosalind M. John
Summary: The study found a sex-specific association between cord serum BDNF levels at birth and attention development parameters in infants at one year old. This finding provides some support for the hypothesis that reduced serum BDNF levels at birth are linked to an increased risk for neurodevelopmental disorders.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Jessica A. Harder, Raina N. Fichorova, Akanksha Srivastava, Aleta Wiley, Katherine E. Burdick, Joseph J. Locascio, Hadine Joffe
Summary: This study found that BDNF levels are positively correlated with the severity of mood symptoms in women with perimenopausal depression symptoms, resembling the pattern seen in hormonally-sensitive PMDD. This suggests the presence of a hormonally-sensitive mood disorder biomarker profile distinct from that of major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Tadahiro Numakawa, Haruki Odaka
Summary: BDNF plays a crucial role in various neural functions through the activation of its high-affinity receptor TrkB, and abnormalities in BDNF signaling have been implicated in neurodegenerative diseases such as Alzheimer's disease. Studies have shown the potential involvement of deregulated BDNF signaling in the pathophysiology of AD, and compounds like flavonoids may offer promise as BDNF-targeting therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Sagun Tiwari, Lili Qi, John Wong, Zhenxiang Han
Summary: According to a meta-analysis, peripheral levels of brain-derived neurotrophic factor (BDNF) significantly decrease in depression compared to nondepressed healthy controls. However, the study reveals significant heterogeneity among the included studies. Factors such as history of depression and alcohol consumption affect the level of BDNF, while age and gender do not impact the heterogeneity. Although decreased BDNF expression is a risk factor for depression, it cannot be used as a reliable biomarker to assess depression in clinical practice.
BRAIN AND BEHAVIOR
(2022)
Review
Clinical Neurology
Amirmohammad Khalaji, Amir Hossein Behnoush, Parnian Shobeiri, Behrad Saeedian, Antonio L. Teixeira, Nima Rezaei
Summary: The study found no significant difference in BDNF levels between patients with OSA and controls, as well as no statistically significant impact of CPAP treatment on BDNF levels. Therefore, BDNF peripheral levels are not significantly altered in OSA or by its related treatment, preventing its use as a biomarker.
SLEEP AND BREATHING
(2023)
Review
Medicine, General & Internal
Michal Piotrkowicz, Marlena Janoska-Jazdzik, Tytus Koweszko, Agata Szulc
Summary: Psychotherapy has been shown to lead to changes in brain structure and function, with BDNF identified as a potential research target. Limited studies indicate that BDNF concentration levels may increase after psychotherapy, but the impact of BDNF gene methylation status remains to be explored.
JOURNAL OF CLINICAL MEDICINE
(2021)
