Article
Environmental Sciences
Ruijie Zhang, Xuming Xu, Dantong Jia, Yitao Lyu, Jingrun Hu, Qian Chen, Weiling Sun
Summary: This study found that antibiotics inhibit denitrification, but sediments help alleviate this inhibition and promote bacterial growth. Sediments have negative effects on antibiotic resistance genes but positive effects on bacterial quantity and denitrification functional genes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Lin Liu, Shan-Bin Guang, Yu Xin, Jie Li, Guo-Fu Lin, Li-Qin Zeng, Shao-Qin He, Yu-Ming Zheng, Guan-Yu Chen, Quan-Bao Zhao
Summary: This study aimed to understand the characteristics and influencing factors of antibiotic resistant genes (ARGs) in the subtropical drinking water river-reservoir system. The results showed that various environmental factors had significant impacts on the abundance and distribution of ARGs, and bacterial host and resistance mechanisms were also correlated with ARGs.
ENVIRONMENTAL POLLUTION
(2023)
Article
Immunology
Winston E. Anthony, Carey-Ann D. Burnham, Gautam Dantas, Jennie H. Kwon
Summary: This review discusses the gut as a reservoir for antimicrobial resistance and pathogen colonization, with a focus on beta-lactam and plasmid-mediated quinolone resistance. It also explores the use of functional metagenomics and long-read sequencing technologies to detect and understand antimicrobial resistance genes within the gut microbiome, as well as the potential for future microbiome-directed methods for detecting and preventing infections.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Environmental Sciences
Hong Yao, Jie Jiang, Hui Wang, Ting Wei, Thangavel Sangeetha, Peizhe Sun, Fangxu Jia, Fang Liu, Fang Fang, Jianhua Guo
Summary: The regional distribution of antibiotic resistance genes is influenced by the use and preference of antibiotics, as well as population movement and transportation development. This study reveals that high-speed railway train wastewater contains a high abundance of antibiotic-resistant pathogens, and the discharge of untreated wastewater may pose severe hazards to human health and ecosystem safety.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Zhe-Chong Wang, I-Wen Lo, Kuan-Hung Lin, An Ning Cheng, Saeid Malek Zadeh, Yen-Hua Huang, Tsung-Lin Li
Summary: This study elucidates the biosynthetic gene cluster of albofungin and the functions of two key genes, orfA and orfL, in vivo, revealing their roles in antimicrobial detoxification/resistance mechanisms.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Microbiology
Delia Gambino, Valeria Gargano, Gaspare Butera, Sonia Sciortino, Mariangela Pizzo, Giuseppa Oliveri, Cinzia Cardamone, Chiara Piraino, Giovanni Cassata, Domenico Vicari, Antonella Costa
Summary: The study focused on antibiotic susceptibility profiles and ESBL production of Salmonella spp. strains, revealing the presence of MDR strains and ESBL producers, posing potential risks in food safety. Further research on antibiotic resistance genes in foodborne strains, especially from a One Health perspective, is warranted.
Review
Environmental Sciences
Dong Ding, Bin Wang, Xiaoan Zhang, Junxi Zhang, Huanhuan Zhang, Xinxin Liu, Zhan Gao, Zengli Yu
Summary: Antibiotic resistance poses a significant threat to human health, and reducing the spread and burden of antibiotic resistance requires implementing control strategies.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Engineering, Environmental
Shuyao Zhu, Bingqing Yang, Yuqian Jia, Feiyu Yu, Zhiqiang Wang, Yuan Liu
Summary: This study aimed to explore the impact of different disinfectants on the horizontal transfer of antibiotic resistance genes (ARGs) and their underlying mechanisms. The results showed that quaternary ammonium salt, organic halogen, alcohol, and guanidine disinfectants significantly facilitated the conjugative transfer, while heavy metals, peroxides, and phenols displayed an inhibitory effect. Furthermore, guanidine disinfectants promoted conjugation through increased cell membrane permeability, over-production of reactive oxygen species (ROS), enhanced SOS response, and altered expression of conjugative transfer-related genes. Moreover, guanidine disinfectants also promoted bacterial energy metabolism and flagellum motility. These findings highlight the potential risks caused by the massive use of guanidine disinfectants, especially during the COVID-19 pandemic.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Microbiology
V. J. Timms, K. A. Hassan, L. A. Pearson, B. A. Neilan
Summary: Antimicrobial resistance (AMR) is a major global health threat, with predictions of 10 million deaths annually by 2050. Cyanobacteria have been found to be a potential reservoir for AMR genes, with these genes found in diverse terrestrial and aquatic habitats.
ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Engineering, Environmental
Yuepeng Deng, Huaihao Xu, Yuting Gu, Yongyin Lan, Junpeng Diao, Zhijian Xiao, Jiaming Zhu, Biqing Li, Jie Zou, Kaoming Zhang, Yuxian Liu, Jingchuan Xue, Han Zhang, Lai Lyu, Chun Hu, Zhu Wang
Summary: This study investigated the occurrence and fate of antibiotics and antibiotic resistance genes (ARGs) in a wastewater treatment plant in Guangzhou. The contribution of each treatment unit to the removal efficiency of antibiotics and ARGs was examined. It was found that disinfection greatly increased the abundance of ARGs and the risk of horizontal gene transfer. Variation partitioning analysis was used to quantify the contribution of environmental factors to microbial community structure and ARGs variation.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Microbiology
Suraia Nusrin, Asaduzzaman Asad, Shoma Hayat, Bitali Islam, Ruma Begum, Fahmida Habib Nabila, Zhahirul Islam
Summary: This study identified the mechanisms of azithromycin resistance in Shigella through whole genome-based analysis. Two new resistance genes and one efflux pump mediator gene were found. Plasmid-borne resistance gene clusters were also detected. The effectiveness of azithromycin against Shigella is predicted to decrease rapidly, highlighting the need for alternative treatments.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Yu Li, Zeling Xu, Wenkai Han, Huiluo Cao, Ramzan Umarov, Aixin Yan, Ming Fan, Huan Chen, Carlos M. Duarte, Lihua Li, Pak-Leung Ho, Xin Gao
Summary: HMD-ARG is a deep learning-based hierarchical multi-task method that provides detailed annotations of ARGs from three important aspects: resistant antibiotic class, resistant mechanism, and gene mobility. Experimental results demonstrate the superior performance of our method over existing methods, as well as its effectiveness and robustness.
Article
Environmental Sciences
Chong Liu, Guichun Li, Xiaobo Qin, Yansheng Xu, Jiarui Wang, Guosheng Wu, Huabing Feng, Jing Ye, Changxiong Zhu, Xiaohua Li, Xiangqun Zheng
Summary: Research has found that the co-selection of environmentally toxic heavy metals affects the resistome in manure, with copper and zinc genes being positively correlated with multiple types of antibiotic resistance genes and forming a complex network. These results indicate that the use of heavy-metal additives in feed increases drug resistance genes in manure through co-selection, aggravating the risk of antimicrobial resistance diffusion from animal farms to manure land applications.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Engineering, Environmental
Zibo Lin, Tao Yuan, Lai Zhou, Sen Cheng, Xu Qu, Ping Lu, Qiyan Feng
Summary: Antibiotic resistance poses significant risks to global public health and ecological environment. Horizontal gene transfer plays a crucial role in the spread of antibiotic resistance genes, and the presence of antibiotic-resistant genes and bacteria in the environment exacerbates the risk of antibiotic resistance transmission.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2021)
Article
Genetics & Heredity
Zhenwei Liu, Tao Zhang, Keke Wu, Zhongshan Li, Xiaomin Chen, Shan Jiang, Lifeng Du, Saisai Lu, Chongxiang Lin, Jinyu Wu, Xiaobing Wang
Summary: Periodontitis, an inflammatory disease characterized by progressive destruction of the periodontium and tooth loss, is associated with dysbiosis of the oral microflora. In this study, metagenomic sequencing was used to investigate the etiology, antibiotic resistance genes (ARGs), and virulence genes (VirGs) of periodontitis. The study revealed a shift in oral microbiota composition and identified functional pathways that were significantly more abundant in periodontitis patients. Furthermore, several positively selected ARGs and VirGs were identified, some of which were found in respiratory tract pathogens. These findings suggest a potential association between periodontitis and respiratory infection at the gene level.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
