Article
Materials Science, Multidisciplinary
Ala Manohar, V. Vijayakanth, S. V. Prabhakar Vattikuti, Ki Hyeon Kim
Summary: The particle size of spinel ferrite nanoparticles plays a crucial role in determining their properties and behavior in biomedical applications. This review focuses on the role of nanoparticle size in various biomedical applications, including induction heating, photocatalysis, and cytotoxicity. The review also discusses the biocompatibility properties and potential applications of spinel ferrite nanoparticles in medicine and the environment.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Physics, Condensed Matter
Imran Ali, Yunxiang Pan, Yasir Jamil, Aqeel Ahmed Shah, Muhammad Amir, Shamoon Al Islam, Yusra Fazal, Jun Chen, Zhonghua Shen
Summary: This study used arc melting to fabricate copper-iron and copper-nickel alloys, which were then used to prepare spherical Cu-Fe and Cu-Ni nanoparticles through laser ablation in water. The synthesized Cu-Ni nanoparticles had an average size of 34 nm, while the Cu-Fe nanoparticles had an average size of 20 nm. Characterization of the materials was done using XRD, VSM, and DLS analyses. Cu-Ni nanoparticles showed higher antibacterial activity than Cu-Fe nanoparticles, and Cu-Ni nanoparticles had slight mutagenic potential against S. typhimurium TA-98 strain but were non-mutagenic against S. typhimurium TA-100 strain. Cu-Fe nanoparticles were non-mutagenic against both strains of S. typhimurium. The specific absorption rates of Cu-Ni nanoparticles were 5.04 and 2.18 W/g, while for Cu-Fe nanoparticles, they were 9.74 and 7.39 W/g, suggesting the potential usefulness of these bimetallic nanomaterials for magnetic hyperthermia.
PHYSICA B-CONDENSED MATTER
(2023)
Article
Chemistry, Multidisciplinary
Shamsa Munir, Faiza Asghar, Faryal Younis, Saira Tabassum, Afzal Shah, Sher Bahadar Khan
Summary: Nanoparticles can be modified with dopants to exhibit antibacterial, antifungal, and antioxidant activities. The doped TiO2 nanoparticles showed improved performance against certain microorganisms, while Ni-TiO2 nanoparticles demonstrated the highest antioxidant capacity.
Article
Pharmacology & Pharmacy
Xuan-Hai Do, Tu Dac Nguyen, Thi Thu Huong Le, Thuy Thanh To, Thi Van Khanh Bui, Nam Hong Pham, Khanh Lam, Thi My Nhung Hoang, Phuong Thu Ha
Summary: This study evaluated the biological activity of nanoconjugates composed of superparamagnetic Fe3O4 nanoparticles coated with alginate and curcumin (Fe3O4/Cur@ALG) in cancer cells. The results showed that Fe3O4 nanoparticles had high biocompatibility and low toxicity in mice. Fe3O4/Cur@ALG enhanced the magnetic resonance imaging contrast and inhibited the growth of sarcoma 180 tumors through magnetic heating and the anticancer effects of curcumin.
Article
Pharmacology & Pharmacy
Victoria R. Gabriele, Robabeh M. Mazhabi, Natalie Alexander, Purna Mukherjee, Thomas N. Seyfried, Njemuwa Nwaji, Eser M. Akinoglu, Andrzej Mackiewicz, Guofu Zhou, Michael Giersig, Michael J. Naughton, Krzysztof Kempa
Summary: The study reveals that melanin nanoparticles exhibit cytotoxicity at high glucose concentrations. Metastatic cancer cells can ingest a large amount of these nanoparticles, with glucose coating enhancing ingestion and slowing down cell death, whereas non-accumulating cells are less susceptible to laser illumination.
Article
Ecology
Xiaohuan Zhao, Xinpeng Fan, Zhiwei Gong, Xilei Gao, Yiwen Wang, Bing Ni
Summary: This study investigated the toxic effects of copper (Cu) and copper oxide (CuO) nanoparticles on the single-celled eukaryote Euplotes aediculatus. The nanoparticles increased the activities of antioxidant enzymes and caused damage to the cell structure, with Cu nanoparticles being more toxic than CuO nanoparticles. Additionally, Cu nanoparticles resulted in nucleoli disappearance, chromatin condensation, and damage to mitochondria and the pellicle. The oxidation of functional groups on the membrane further confirmed the severe damage caused by Cu nanoparticles. Overall, oxidative stress and organelle destruction played important roles in the toxic effects of these nanoparticles on E. aediculatus.
Article
Materials Science, Multidisciplinary
Roya Kavkhani, Abdollah Hajalilou, Ebrahim Abouzari-Lotf, Liliana P. Ferreira, Maria Margarida Cruz, Mostafa Yusefi, Elahe Parvini, Alireza Bali Ogholbeyg, Umi Nabilah Ismail
Summary: Magnetic fluid hyperthermia (MFH) is a promising cancer therapeutic approach that can be used in conjunction with other treatment methods. It is important to find innovative materials with a higher specific absorption rate (SAR) to further reduce the dose of magnetic nanoparticles in tumor treatment through MFH, while being suitable for MRI as well.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Ala Manohar, V. Vijayakanth, Ki Hyeon Kim
Summary: The synthesized nanoparticles exhibit excellent magnetic properties and show significant potential for application in magnetic hyperthermia. The prepared samples have high heat efficiency and can be used as magnetic hyperthermia mediators. The research findings suggest that the prepared NPs are of great significance for magnetic hyperthermia applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Materials Science, Composites
Anna Kobets, Tatiana Vorobyova, Maria Galuza, Anton Kudaka, Uladzimir Novikau
Summary: This study developed a method for obtaining electroconductive polyacrylate coatings filled with bimetal particles and graphene nanoplatelets. The coatings exhibited high conductivity and can be used for production of conductive elements on glass and other substrates.
POLYMER COMPOSITES
(2023)
Article
Chemistry, Multidisciplinary
Milos Ognjanovic, Zeljko Jacimovic, Milica Kosovic-Perutovic, Irina Besu Zizak, Tatjana Stanojkovic, Zeljko Zizak, Biljana Dojcinovic, Dalibor M. Stankovic, Bratislav Antic
Summary: Partial cation substitution can change the physical properties of compounds, and in this study, yttrium-substituted iron oxide nanoconstructs (YIONs) were prepared. The Y3+ substitution in maghemite (γ-Fe2O3) crystal structures was limited to 1.5%. The YIONs showed excellent heating efficiency and low toxicity, making them suitable for potential medical and technological applications such as magnetic hyperthermia cancer treatment and catalysis.
Article
Nanoscience & Nanotechnology
Kaihang Han, Shuo Wang, Qiying Liu, Fagen Wang
Summary: The study demonstrated the synthesis of Ni-Cu alloy nanoparticles for methane dry reforming, showing the impact of Ni/Cu ratio on MDR performance. Addition of a proper quantity of Cu promoted CO2 activation, while excessive Cu formed individual Cu nanoparticles, affecting Ni atoms on the surface and complicating CH4 activation.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ping Zhou, Xianming Zhang, Qinghua Yu, Shiyu Yang, Jiashan Xia, Tao Deng, Chao Yu
Summary: The study fabricated an integrated agent Ag@Cu with broad NIR absorption, improving the efficacy of photodynamic therapy and alleviating tumor hypoxia. The introduction of metal ions also enhanced chemodynamic therapy and ROS-mediated therapy, making it a promising multimodal tumor treatment approach.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Ala Manohar, V. Vijayakanth, Krishnamoorthi Chintagumpala, Panchanathan Manivasagan, Eue- Soon Jang, Ki Hyeon Kim
Summary: Mn1-xZnxFe2O4 (x = 0.1, 0.3, 0.4, & 0.5) magnetic nanoparticles (NPs) were prepared using the solvothermal reflux method, and their single phase preparation was confirmed by X-ray diffraction. The addition of Zn greatly improved the magnetic properties of the prepared NPs, increasing their magnetization value. The Zn0.1Mn0.9Fe2O4 NPs showed the highest specific loss power (SLP) value among the samples, indicating their potential for effective heat generation in magnetic hyperthermia therapy.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Nanoscience & Nanotechnology
Mostafa Yusefi, Kamyar Shameli, Ong Su Yee, Sin-Yeang Teow, Ziba Hedayatnasab, Hossein Jahangirian, Thomas J. Webster, Kamil Kuca
Summary: This study presented a green synthesis method of Fe3O4 nanoparticles using plant waste extract as a stabilizer, demonstrating potential applications in magnetic hyperthermia and colon cancer treatment. The synthesized nanoparticles exhibited good stability and enhanced cytotoxic effects against colon cancer cells, showcasing promising biomedical properties.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Materials Science, Multidisciplinary
Arunima Rajan, Beata Kaczmarek-Szczepanskac, Niroj Kumar Sahu
Summary: In this study, iron oxide nanoparticles with high crystallinity and hydrophilicity were synthesized, showing improved specific loss power in hyperthermia tests. The nanoparticles exhibited concentration-dependent effects with anticancer activity towards cancer cells and biocompatibility towards normal cells. Additionally, minimal damage to erythrocyte membrane was induced by the nanoparticles.
MATERIALS TODAY COMMUNICATIONS
(2021)
Letter
Biochemistry & Molecular Biology
Filip Fratev, Denisse A. Gutierrez, Renato J. Aguilera, Ashish Tyagi, Chendil Damodaran, Suman Sirimulla
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Oncology
Sayuri Nakamura-Bencomo, Denisse A. Gutierrez, Elisa Robles-Escajeda, Blanca Iglesias-Figueroa, Tania S. Siqueiros-Cendon, Edward A. Espinoza-Sanchez, Sigifredo Arevalo-Gallegos, Renato J. Aguilera, Quintin Rascon-Cruz, Armando Varela-Ramirez
Summary: The research shows that rhLf-h-glycan has potential toxicity against cancer cells, exhibiting selective cytotoxicity towards cancer cells while sparing normal cells. It also demonstrates significant anti-proliferative activity and induces apoptosis in cancer cells under experimental conditions.
INVESTIGATIONAL NEW DRUGS
(2021)
Article
Chemistry, Physical
Md Ariful Ahsan, Alain R. Puente Santiago, Mohamed F. Sanad, J. Mark Weller, Olivia Fernandez-Delgado, Luis A. Barrera, Viridiana Maturano-Rojas, Bonifacio Alvarado-Tenorio, Candace K. Chan, Juan C. Noveron
Summary: A facile, scalable and green synthetic methodology was reported to fabricate porous carbon encapsulated transition metal nanocatalysts using commercial tissue paper. Among them, Co@TP-6 showed the most active catalytic performance, while Ni@TP-6 exhibited the best electrocatalytic performance.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Elhussein M. Hashem, Mahmoud A. Hamza, Ayat N. El-Shazly, Mohamed F. Sanad, Minatallah M. Hassan, Sameh O. Abdellatif
Summary: A novel ternary nanocomposite of Ag@RGO/ZnO was successfully synthesized using a facile one-pot method at room temperature, which functions as a low-cost, efficient, and reliable UV absorber. The optical characterization showed enhanced light absorption in the UV portion, attributed to the synergetic effect of Ag nanoparticles and RGO nanosheets. Additionally, the band-gap narrowing due to Ag-doping suggests potential applications for this nanocomposite.
Article
Nanoscience & Nanotechnology
Nayera F. A. Salem, Samia S. Abouelkheir, Asmaa M. Yousif, Bianca P. Meneses-Brassea, Soraya A. Sabry, Hanan A. Ghozlan, Ahmed A. El-Gendy
Summary: Magnetic iron oxide nanoparticles have attracted significant attention in biotechnological fields, particularly in biomedicine. This study introduces a novel method of biosynthesis using halophilic archaea and demonstrates the potential of these nanoparticles for hyperthermia treatment in cancer therapy. Further research is needed to explore their application in in vitro/in vivo hyperthermia studies.
Article
Chemistry, Multidisciplinary
Mohamed Fathi Sanad, Alain R. Puente Santiago, Sarah A. Tolba, Md Ariful Ahsan, Olivia Fernandez-Delgado, Mina Shawky Adly, Elhussein M. Hashem, Mohamed Mahrous Abodouh, M. Samy El-Shall, Sreeprasad T. Sreenivasan, Nageh K. Allam, Luis Echegoyen
Summary: A novel nonprecious Co-Cu bimetallic metal-organic framework (MOF) catalyst was reported, which exhibited superior electrocatalytic activity for ORR in alkaline environments compared to Pt/C, along with higher electrochemical stability and better performance. This outstanding behavior was attributed to the unique electronic synergy of the Co-Cu bimetallic centers in the MOF network, as revealed by XPS and PDOS analysis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Kalpana Tilekar, Jessica D. Hess, Neha Upadhyay, Markus Schweipert, Felix Flath, Denisse A. Gutierrez, Fulvio Loiodice, Antonio Lavecchia, Franz-Josef Meyer-Almes, Renato J. Aguilera, C. S. Ramaa
Summary: Recent research has identified a novel series of thiazolidinedione (TZD) derivatives as potential HDAC4 inhibitors, with compound 5 y showing the most promising antiproliferative and apoptotic effects in lymphoblastic leukemia and breast cancer cells. This series of compounds also demonstrated Class IIa (HDAC4) selectivity, suggesting their potential as targeted cancer therapeutic agents.
Editorial Material
Biochemistry & Molecular Biology
Blanca E. Ruiz-Medina, Armando Varela-Ramirez, Robert A. Kirken, Elisa Robles-Escajeda
Summary: The origin of the COVID-19 pandemic remains unclear, with two potential scenarios being zoonotic transfer and a laboratory leak. While the Wuhan wet markets provide a strong scenario for zoonotic transfer, the lack of direct evidence remains a challenge. The laboratory origin remains plausible given the work conducted at the Wuhan Institute of Virology, highlighting the need for a definitive conclusion to prevent future pandemics.
Article
Cell Biology
Denisse A. Gutierrez, Lisett Contreras, Paulina J. Villanueva, Edgar A. Borrego, Karla Moran-Santibanez, Jessica D. Hess, Rebecca DeJesus, Manuel Larragoity, Ana P. Betancourt, Jonathon E. Mohl, Elisa Robles-Escajeda, Khodeza Begum, Sourav Roy, Robert A. Kirken, Armando Varela-Ramirez, Renato J. Aguilera
Summary: In this study, a novel pyrazole-based derivative (P3C) was found to exhibit strong cytotoxicity against various human cancer cell lines, especially triple-negative breast cancer cells. The mechanism of cytotoxicity involves the accumulation of reactive oxygen species (ROS), mitochondrial depolarization, and activation of apoptotic pathways.
Article
Oncology
Risa Mia Swain, Lisett Contreras, Armando Varela-Ramirez, Mohammad Hossain, Umashankar Das, Carlos A. Valenzuela, Manuel L. Penichet, Jonathan R. Dimmock, Renato J. Aguilera
Summary: Two novel piperidone compounds demonstrated cytotoxicity against various cancer cell lines and induced cell death through the intrinsic apoptotic pathway. They also caused cell cycle alteration and acted as proteasome inhibitors.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Biology
Jessica D. Hess, Luca H. Macias, Denisse A. Gutierrez, Karla Moran-Santibanez, Lisett Contreras, Stephanie Medina, Paulina J. Villanueva, Robert A. Kirken, Armando Varela-Ramirez, Manuel L. Penichet, Renato J. Aguilera
Summary: This study discovered a unique thienopyrazole derivative, Tpz-1, with potent and selective cytotoxic effects on various cancer cells. Tpz-1 interferes with signaling pathways and cytoskeletal components important to cell shape, organization, growth, and division. These findings support further exploration of Tpz-1 and other thienopyrazole-based compounds as potential anticancer agents.
Article
Chemistry, Multidisciplinary
Md Nurul Huda, Isaac G. Deaguro, Edgar A. Borrego, Raj Kumar, Tamanna Islam, Humayra Afrin, Armando Varela-Ramirez, Renato J. Aguilera, Eden E. L. Tanner, Md Nurunnabi
Summary: This study developed a topical formulation composed of Navitoclax and an ionic liquid of choline octanoate. The results showed that COA-mediated topical delivery of Navitoclax was more effective in treating early-stage melanoma than oral administration.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Pravesh M. Jain, Denisse A. Gutierrez, Sujeet Kumar, Renato J. Aguilera, Subhas S. Karki
Summary: A series of pyrazole-oxindole conjugates were studied as potential cytotoxic agents. The compound 5-methyl-3-((3-(1-phenyl)-3-(p-tolyl)-1H-pyrazol-4-yl)methylene)indolin-2-one 6h showed the highest cytotoxic activity against Jurkat cells with a CC50 of 4.36 +/- 0.2 μM. Mechanistic studies revealed that 6h induced apoptosis in a dose-response manner, without generating reactive oxygen species (ROS) and altering mitochondrial health.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Materials Science, Biomaterials
Jyoti Ahlawat, Gabriela Henriquez, Armando Varela-Ramirez, Robert Fairman, Mahesh Narayan
Summary: Green-chemistry synthesized gelatin-derived carbon quantum dots (CQDs) can mitigate the neurotoxic effects of paraquat and extend organismal lifespan. The study shows that this sustainable nanomaterial can protect cell lines and organisms against neurotoxic outcomes.
BIOMATERIALS ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Olivia Fernandez-Delgado, Alain R. Puente Santiago, Jolaine Galindo Betancourth, Mohamed F. Sanad, Sreeprasad T. Sreenivasan, Luis Echegoyen
Summary: Considerable efforts are being made to find cheaper and more efficient alternatives to currently available catalysts for the Hydrogen Evolution Reaction (HER). Fullerenes have gained attention for their suitable electronic properties and easy functionalization. Covalent functionalization of fullerenes enhances their catalytic performance and improves the efficiency of hydrogen generation.