期刊
MOLECULAR THERAPY-NUCLEIC ACIDS
卷 23, 期 -, 页码 42-54出版社
CELL PRESS
DOI: 10.1016/j.omtn.2020.10.030
关键词
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资金
- Scientific Foundation of Shaanxi Province [2019ZDLSF01-02-01, 2018SF240]
- National Clinical Research Center for Digestive Diseases [2015BAI13B07]
- State Key Laboratory of Cancer Biology [CBSKL2014Z13]
Colorectal cancer is the third most common cancer with high mortality rates, mainly attributed to metastasis. MicroRNAs play a significant role in manipulating malignant phenotypes in CRC, and certain miRNAs related to metastasis have potential as biomarkers or therapeutic targets. Further research is needed to translate these findings into clinical applications.
Colorectal cancer (CRC), ranking as the third commonest cancer, leads to extremely high rates of mortality. Metastasis is the major cause of poor outcome in CRC. When metastasis occurs, 5-year survival rates of patients decrease sharply, and strategies to enhance a patient's lifetime seem limited. MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that are significantly involved in manipulation of CRC malignant phenotypes, including proliferation, invasion, and metastasis. To date, accumulating studies have revealed the mechanisms and functions of certain miRNAs in CRC metastasis. However, there is no systematic discussion about the biological implications and clinical potential (diagnostic role, prognostic role, and targeted therapy potential) of metastasis-related miRNAs in CRC. This review mainly summarizes the recent advances of miRNA-mediated metastasis in CRC. We also discuss the clinical values of metastasis-related miRNAs as potential biomarkers or therapeutic targets in CRC. Moreover, we envisage the future orientation and challenges in translating these findings into clinical applications.
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