4.3 Article

Quantifying the learning curve of emergent total arch replacement in acute type A aortic dissection

期刊

JOURNAL OF THORACIC DISEASE
卷 12, 期 8, 页码 4070-4081

出版社

AME PUBL CO
DOI: 10.21037/jtd-20-912

关键词

Acute aortic dissection; learning curve; total arch replacement; emergent operation

资金

  1. National Natural Science Foundation of China Youth Science Foundation Project [81801743]

向作者/读者索取更多资源

Background: Acute type A aortic dissection with arch involvement is a life-threatening condition, which requires immediate surgical attention. Emergent total arch replacement and root reconstruction is a technically demanding operation with varying outcomes based on surgeon experience. The human factors in total arch replacement in the emergent setting have never been systematically investigated. The ability of surgeons with low volumes to achieve acceptable results in their start-up period is not known. Methods: From January 2013 to December 2016, patients with acute type A aortic dissection who underwent emergent total arch replacement with three surgeons were enrolled. Basic characteristics, procedural and postoperative outcomes were collected. The time of critical surgical steps and operative mortality were calculated using descriptive statistics and cumulative SUM (CUSUM) analysis. Results: A total of 300 patients (age 53.8 +/- 11.5 years, female 63, 21.0%) with acute type A aortic dissection underwent emergent total arch replacement. A total of 219 patients (73.0%) had root reinforcement, 295 patients (98.3%) underwent frozen elephant trunk repair. Mean circulatory arrest and cross-clamp times were 29.8 +/- 9.8 and 112.3 +/- 32.1 min, respectively. The operative mortality was 6.7%, the stroke rate was 4.0%. The mean length of postoperative ICU and hospital stays were 8.4 +/- 10.6 and 18.0 +/- 12.2 days, respectively. By CUSUM depictions, surgeons appeared to have different learning curves with regards to operative time. By CUSUM failure analysis on operative mortality, two newly appointed surgeons in their start-up period stayed in an acceptable range, while one senior surgeon with higher volumes experienced superior outcomes and better performance. Conclusions: Although emergent total arch replacement for acute type A dissection is a complex scenario, surgeons well-trained in adult cardiac surgery are able to achieve acceptable results in their start-up period.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Nanoscience & Nanotechnology

Controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia-reperfusion injury

Wenshuo Wang, Huan Liu, Yuntao Lu, Xiaole Wang, Bohan Zhang, Shuo Cong, Yun Zhao, Minbiao Ji, Hongyue Tao, Lai Wei

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Article Biochemistry & Molecular Biology

Myeloperoxidase As a Multifaceted Target for Cardiovascular Protection

Chrishan J. A. Ramachandra, K. P. Myu Mai Ja, Jasper Chua, Shuo Cong, Winston Shim, Derek J. Hausenloy

ANTIOXIDANTS & REDOX SIGNALING (2020)

Review Cardiac & Cardiovascular Systems

Human-induced pluripotent stem cells for modelling metabolic perturbations and impaired bioenergetics underlying cardiomyopathies

Chrishan J. A. Ramachandra, Jasper Chua, Shuo Cong, Myu Mai Ja Kp, Winston Shim, Joseph C. Wu, Derek J. Hausenloy

Summary: Normal cardiac functions depend on continuous energy supply. Metabolic disturbances and impaired mitochondrial bioenergetics underlie various cardiac diseases, but specific treatments are lacking. Patient-derived iPSCs show promise for studying cardiomyopathies and novel therapies.

CARDIOVASCULAR RESEARCH (2021)

Article Respiratory System

Postoperative hypothermia after total aortic arch replacement in acute type A aortic dissection-multivariate analysis and risk identification for postoperative hypothermia occurrence

Huan Liu, Xiuwen Wang, Shun Liu, Shuo Cong, Yuntao Lu, Ye Yang, Wenshuo Wang, Hao Lai, Xin Li, Lai Wei, Chunsheng Wang

JOURNAL OF THORACIC DISEASE (2020)

Article Biochemistry & Molecular Biology

Oxidative stress in cardiac hypertrophy: From molecular mechanisms to novel therapeutic targets

Chrishan J. A. Ramachandra, Shuo Cong, Xavier Chan, En Ping Yap, Fan Yu, Derek J. Hausenloy

Summary: Cardiac hypertrophy is an adaptive change of the heart to maintain normal function, with oxidative stress identified as a critical inducer. In addition to traditional mediators of oxidative stress, metabolic disturbances, mitochondrial dysfunction, inflammation, dysregulated autophagy, and protein homeostasis also contribute to cardiac pathophysiology through oxidative stress mechanisms. Novel therapeutic targets and repurposed drugs aimed at counteracting oxidative stress have shown promise in attenuating cardiac hypertrophy.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Biochemistry & Molecular Biology

Unravelling the Interplay between Cardiac Metabolism and Heart Regeneration

Fan Yu, Shuo Cong, En Ping Yap, Derek J. Hausenloy, Chrishan J. Ramachandra

Summary: Ischemic heart disease is a major cause of heart failure and has a significant impact on global health. The limited regenerative capacity of cardiomyocytes poses challenges for heart repair. Recent research has shown that cardiac metabolism plays a crucial role in heart regeneration and modulating this metabolism could promote regeneration. However, there is a lack of mechanistic understanding in this field, hindering the development of effective therapeutic strategies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

暂无数据