Article
Cardiac & Cardiovascular Systems
Andrew M. Vekstein, Julie W. Doberne, E. Hope Weissler, Charles M. Wojnarski, Chandler A. Long, Adam R. Williams, Ryan P. Plichta, Jeffrey G. Gaca, G. Chad Hughes
Summary: After limited root/ascending repair for acute type A aortic dissection, a significant proportion of patients require distal reintervention, especially for arch pathology. This study presents an institutional algorithm for the management of the arch after previous limited repair, demonstrating promising operative and long-term outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Likang Ma, Tianci Chai, Xiaojie Yang, Xinghui Zhuang, Qingsong Wu, Liangwan Chen, Zhihuang Qiu
Summary: This study suggests that hemiarch replacement surgery may lead to better early outcomes for patients with ATAAD, but it is associated with a higher late mortality rate compared to total arch replacement. Decisions regarding the extent of arch repair should be based on the location and severity of ATAAD, as well as the experience of surgeons.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Qiang Xie, Chengnan Li, Yongliang Zhong, Congcong Luo, Rutao Guo, Yongmin Liu, Jun Zheng, Yipeng Ge, Lizhong Sun, Junming Zhu
Summary: This study evaluated the impact of transfusing different blood products on postoperative mechanical ventilation time in patients with ATAAD. The study found that transfusion of pRBCs and PC, as well as age, were independent risk factors for prolonged mechanical ventilation after surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Igor Vendramin, Daniela Piani, Andrea Lechiancole, Sandro Sponga, Concetta Di Nora, Francesco Londero, Daniele Muser, Francesco Onorati, Uberto Bortolotti, Ugolino Livi
Summary: The study compares the outcomes of two different surgical strategies for patients with acute Type A aortic dissection (A-AAD). It shows that an aggressive approach to A-AAD provides better long-term results without increasing mortality, and immediate aortic arch replacement during A-AAD repair leads to a lower incidence of late aortic-related complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jun Li, Yiping Sun, Tianyu Zhou, Yongshi Wang, Yongxin Sun, Hao Lai, Chunsheng Wang
Summary: The study compared early and mid-term outcomes between David reimplantation and the Bentall procedure with TAR and SET in ATAAD patients, finding comparable in-hospital mortality and incidence of major perioperative complications between the two groups.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Lin Xia, Yu Liu, Zhonglu Yang, Yuguang Ge, Lu Wang, Yejun Du, Yinan Dong, Hui Jiang
Summary: This study analyzed the learning curve of total arch replacement (TAR) with moderate hypothermic circulatory arrest via a single upper hemisternotomy (UHS) approach, in order to guide surgeons in adopting minimally invasive procedures.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Keiji Uchida, Tomoyuki Minami, Tomoki Cho, Shota Yasuda, Keiichiro Kasama, Shinichi Suzuki, Munetaka Masuda
Summary: Total arch replacement is associated with fewer distal aortic events in patients with type A acute aortic dissection, compared to ascending aortic replacement. The distal aortic event-free rate in the ascending aortic replacement group decreases over time, while the rate remains stable in the total arch replacement group. Patients with a dissected arch are at higher risk of distal aortic events.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Surgery
Masahiko Narita, Masahiro Tsutsui, Ryouhei Ushioda, Yuta Kikuchi, Tomonori Shirasaka, Natsuya Ishikawa, Hiroyuki Kamiya
Summary: This study compared the short- and long-term outcomes of proximal repair and extensive arch surgery for acute DeBakey type I aortic dissection. The results showed no significant differences in long-term cumulative survival and freedom from aortic reintervention between the two surgical strategies. Limited aortic resection appears to achieve acceptable patient outcomes.
FRONTIERS IN SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Enzehua Xie, Jinlin Wu, Juntao Qiu, Lu Dai, Jiawei Qiu, Qipeng Luo, Wenxiang Jiang, Fangfang Cao, Rui Zhao, Shuya Fan, Wei Gao, Hongwei Guo, Xiaogang Sun, Cuntao Yu
Summary: This study compared the early outcomes of three surgical techniques for type I aortic dissection and found no significant differences among them. Therefore, the choice of surgical procedure can be relatively flexible based on patient status and surgeon expertise. Long-term investigations are needed to further assess the equivalence in efficacy and safety of these approaches.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Oncology
Zhifa Zheng, Lingbo Yang, Zhongjie Zhang, Dong Wang, Junqing Zong, Likui Zhang, Xuening Wang
Summary: This study found that for patients with acute Stanford Type A aortic dissection without rupture, non-total aortic arch replacement surgery has a simple surgical method, high perioperative safety, and long-term efficacy similar to total arch replacement.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Yanxiang Liu, Yi Shi, Hongwei Guo, Cuntao Yu, Xiangyang Qian, Wei Wang, Xiaogang Sun
Summary: The aortic balloon occlusion (ABO) technique significantly shortens the circulatory arrest time in total arch replacement (TAR) and frozen elephant trunk (FET) procedures for acute type A aortic dissection. Clinical data suggest a protective effect on liver and kidney function, but further large-sample studies are needed for thorough evaluation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Hongyuan Lin, Yi Chang, Hongwei Guo, Xiangyang Qian, Xiaogang Sun, Cuntao Yu
Summary: This study developed a simple and effective nomogram model to predict the 30-day mortality rate in acute type A aortic dissection patients undergoing total aortic arch replacement with frozen elephant trunk technique. By collecting clinical data, the study identified certain predictors that independently predicted the 30-day mortality rate, and the nomogram demonstrated good calibration and discrimination.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Parth Mukund Patel, Andy Dong, Edward Chiou, Jane Wei, Jose Binongo, Bradley Leshnower, Edward P. Chen
Summary: This study compared the outcomes of no arch intervention, hemiarch replacement, and total arch replacement in patients with type A aortic syndromes. The results showed that despite longer surgery time, arch intervention was not associated with worse operative or long-term outcomes.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Cheng-Nan Li, Yi-Peng Ge, Hao Liu, Chen-Han Zhang, Yong-Liang Zhong, Su-Wei Chen, Yong-Min Liu, Jun Zheng, Jun-Ming Zhu, Li-Zhong Sun
Summary: This study evaluated the impact of transfusions of pRBCs, FFP, and PC on AKI in patients with ATAAD undergoing TAR. The results showed that pRBCs and PC transfusions were independent risk factors for AKI, while FFP transfusion was not associated with an increased risk of AKI.
HEART LUNG AND CIRCULATION
(2022)
Review
Cardiac & Cardiovascular Systems
Ameen M. Basha, Randy D. Moore, Kenton L. Rommens, Eric J. Herget, R. Scott McClure
Summary: TEAAR is an emerging alternative for the treatment of aortic arch disease in high-risk patients. A systematic review of TEAAR was conducted to evaluate its early outcomes. The study found that TEAAR is mainly indicated for chronic arch dissection with degenerative aneurysmal disease and pure arch aneurysm.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Wenshuo Wang, Huan Liu, Yuntao Lu, Xiaole Wang, Bohan Zhang, Shuo Cong, Yun Zhao, Minbiao Ji, Hongyue Tao, Lai Wei
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Chrishan J. A. Ramachandra, K. P. Myu Mai Ja, Jasper Chua, Shuo Cong, Winston Shim, Derek J. Hausenloy
ANTIOXIDANTS & REDOX SIGNALING
(2020)
Review
Cardiac & Cardiovascular Systems
Chrishan J. A. Ramachandra, Jasper Chua, Shuo Cong, Myu Mai Ja Kp, Winston Shim, Joseph C. Wu, Derek J. Hausenloy
Summary: Normal cardiac functions depend on continuous energy supply. Metabolic disturbances and impaired mitochondrial bioenergetics underlie various cardiac diseases, but specific treatments are lacking. Patient-derived iPSCs show promise for studying cardiomyopathies and novel therapies.
CARDIOVASCULAR RESEARCH
(2021)
Article
Respiratory System
Huan Liu, Xiuwen Wang, Shun Liu, Shuo Cong, Yuntao Lu, Ye Yang, Wenshuo Wang, Hao Lai, Xin Li, Lai Wei, Chunsheng Wang
JOURNAL OF THORACIC DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Chrishan J. A. Ramachandra, Shuo Cong, Xavier Chan, En Ping Yap, Fan Yu, Derek J. Hausenloy
Summary: Cardiac hypertrophy is an adaptive change of the heart to maintain normal function, with oxidative stress identified as a critical inducer. In addition to traditional mediators of oxidative stress, metabolic disturbances, mitochondrial dysfunction, inflammation, dysregulated autophagy, and protein homeostasis also contribute to cardiac pathophysiology through oxidative stress mechanisms. Novel therapeutic targets and repurposed drugs aimed at counteracting oxidative stress have shown promise in attenuating cardiac hypertrophy.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Fan Yu, Shuo Cong, En Ping Yap, Derek J. Hausenloy, Chrishan J. Ramachandra
Summary: Ischemic heart disease is a major cause of heart failure and has a significant impact on global health. The limited regenerative capacity of cardiomyocytes poses challenges for heart repair. Recent research has shown that cardiac metabolism plays a crucial role in heart regeneration and modulating this metabolism could promote regeneration. However, there is a lack of mechanistic understanding in this field, hindering the development of effective therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)